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Page 1
Structural basis for the inhibition of βFXIIa by garadacimab.
Drulyte I, Ghai R, Ow SY, Kapp EA, Quek AJ, Panousis C, Wilson MJ, Nash AD, Pelzing M. Drulyte I, et al. Among authors: quek aj. Structure. 2024 Oct 3;32(10):1705-1710.e3. doi: 10.1016/j.str.2024.07.001. Epub 2024 Jul 25. Structure. 2024. PMID: 39059382
Bacteria.guru: Comparative Transcriptomics and Co-Expression Database for Bacterial Pathogens.
Lim PK, Davey EE, Wee S, Seetoh WS, Goh JC, Zheng X, Phang SKA, Seah ESK, Ng JWZ, Wee XJH, Quek AJH, Lim JJ, Rodrigues EE, Lee H, Lim CY, Tan WZ, Dan YR, Lee B, Chee SEL, Lim ZZE, Guan JS, Tan IJL, Arong TJ, Mutwil M. Lim PK, et al. Among authors: quek ajh. J Mol Biol. 2022 Jun 15;434(11):167380. doi: 10.1016/j.jmb.2021.167380. Epub 2021 Nov 25. J Mol Biol. 2022. PMID: 34838806
Human Plasminogen Exacerbates Clostridioides difficile Enteric Disease and Alters the Spore Surface.
Awad MM, Hutton ML, Quek AJ, Klare WP, Mileto SJ, Mackin K, Ly D, Oorschot V, Bosnjak M, Jenkin G, Conroy PJ, West N, Fulcher A, Costin A, Day CJ, Jennings MP, Medcalf RL, Sanderson-Smith M, Cordwell SJ, Law RHP, Whisstock JC, Lyras D. Awad MM, et al. Among authors: quek aj. Gastroenterology. 2020 Oct;159(4):1431-1443.e6. doi: 10.1053/j.gastro.2020.06.032. Epub 2020 Jun 20. Gastroenterology. 2020. PMID: 32574621
Structure and Function Characterization of the a1a2 Motifs of Streptococcus pyogenes M Protein in Human Plasminogen Binding.
Quek AJH, Mazzitelli BA, Wu G, Leung EWW, Caradoc-Davies TT, Lloyd GJ, Jeevarajah D, Conroy PJ, Sanderson-Smith M, Yuan Y, Ayinuola YA, Castellino FJ, Whisstock JC, Law RHP. Quek AJH, et al. J Mol Biol. 2019 Sep 6;431(19):3804-3813. doi: 10.1016/j.jmb.2019.07.003. Epub 2019 Jul 8. J Mol Biol. 2019. PMID: 31295457 Free PMC article.
Structural studies of plasmin inhibition.
Wu G, Quek AJ, Caradoc-Davies TT, Ekkel SM, Mazzitelli B, Whisstock JC, Law RHP. Wu G, et al. Among authors: quek aj. Biochem Soc Trans. 2019 Apr 30;47(2):541-557. doi: 10.1042/BST20180211. Epub 2019 Mar 5. Biochem Soc Trans. 2019. PMID: 30837322 Review.
Tranexamic acid is an active site inhibitor of urokinase plasminogen activator.
Wu G, Mazzitelli BA, Quek AJ, Veldman MJ, Conroy PJ, Caradoc-Davies TT, Ooms LM, Tuck KL, Schoenecker JG, Whisstock JC, Law RHP. Wu G, et al. Among authors: quek aj. Blood Adv. 2019 Mar 12;3(5):729-733. doi: 10.1182/bloodadvances.2018025429. Blood Adv. 2019. PMID: 30814058 Free PMC article.
X-ray crystal structure of plasmin with tranexamic acid-derived active site inhibitors.
Law RHP, Wu G, Leung EWW, Hidaka K, Quek AJ, Caradoc-Davies TT, Jeevarajah D, Conroy PJ, Kirby NM, Norton RS, Tsuda Y, Whisstock JC. Law RHP, et al. Among authors: quek aj. Blood Adv. 2017 May 9;1(12):766-771. doi: 10.1182/bloodadvances.2016004150. eCollection 2017 May 9. Blood Adv. 2017. PMID: 29296720 Free PMC article.
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