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Genomic Discovery and Structure-Activity Exploration of a Novel Family of Enzyme-Activated Covalent Cyclin-Dependent Kinase Inhibitors.
Davison JR, Hadjithomas M, Romeril SP, Choi YJ, Bentley KW, Biggins JB, Chacko N, Castaldi MP, Chan LK, Cumming JN, Downes TD, Eisenhauer EL, Fei F, Fontaine BM, Endalur Gopinarayanan V, Gurnani S, Hecht A, Hosford CJ, Ibrahim A, Jagels A, Joubran C, Kim JN, Lisher JP, Liu DD, Lyles JT, Mannara MN, Murray GJ, Musial E, Niu M, Olivares-Amaya R, Percuoco M, Saalau S, Sharpe K, Sheahan AV, Thevakumaran N, Thompson JE, Thompson DA, Wiest A, Wyka SA, Yano J, Verdine GL. Davison JR, et al. Among authors: lyles jt. J Med Chem. 2024 Aug 8;67(15):13147-13173. doi: 10.1021/acs.jmedchem.4c01095. Epub 2024 Jul 30. J Med Chem. 2024. PMID: 39078366 Free PMC article.
Ethnobotany and the Role of Plant Natural Products in Antibiotic Drug Discovery.
Porras G, Chassagne F, Lyles JT, Marquez L, Dettweiler M, Salam AM, Samarakoon T, Shabih S, Farrokhi DR, Quave CL. Porras G, et al. Among authors: lyles jt. Chem Rev. 2021 Mar 24;121(6):3495-3560. doi: 10.1021/acs.chemrev.0c00922. Epub 2020 Nov 9. Chem Rev. 2021. PMID: 33164487 Free PMC article. Review.
Chronic hyperglycemia aggravates lung function in a Scnn1b-Tg murine model.
Cui G, Moustafa DA, Zhao S, Cegla AV, Lyles JT, Goldberg JB, Chandler JD, McCarty NA. Cui G, et al. Among authors: lyles jt. Am J Physiol Lung Cell Mol Physiol. 2024 Oct 1;327(4):L473-L486. doi: 10.1152/ajplung.00279.2023. Epub 2024 Jul 16. Am J Physiol Lung Cell Mol Physiol. 2024. PMID: 39010826
26 results