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Super-relaxed myosins contribute to respiratory muscle hibernation in mechanically ventilated patients.
van den Berg M, Shi Z, Claassen WJ, Hooijman P, Lewis CTA, Andersen JL, van der Pijl RJ, Bogaards SJP, Conijn S, Peters EL, Begthel LPL, Uijterwijk B, Lindqvist J, Langlais PR, Girbes ARJ, Stapel S, Granzier H, Campbell KS, Ma W, Irving T, Hwee DT, Hartman JJ, Malik FI, Paul M, Beishuizen A, Ochala J, Heunks L, Ottenheijm CAC. van den Berg M, et al. Among authors: ochala j. Sci Transl Med. 2024 Jul 31;16(758):eadg3894. doi: 10.1126/scitranslmed.adg3894. Epub 2024 Jul 31. Sci Transl Med. 2024. PMID: 39083588
A myopathy-related actin mutation increases contractile function.
Lindqvist J, Pénisson-Besnier I, Iwamoto H, Li M, Yagi N, Ochala J. Lindqvist J, et al. Among authors: ochala j. Acta Neuropathol. 2012 May;123(5):739-46. doi: 10.1007/s00401-012-0962-z. Epub 2012 Feb 23. Acta Neuropathol. 2012. PMID: 22358459
Impairments in contractility and cytoskeletal organisation cause nuclear defects in nemaline myopathy.
Ross JA, Levy Y, Ripolone M, Kolb JS, Turmaine M, Holt M, Lindqvist J, Claeys KG, Weis J, Monforte M, Tasca G, Moggio M, Figeac N, Zammit PS, Jungbluth H, Fiorillo C, Vissing J, Witting N, Granzier H, Zanoteli E, Hardeman EC, Wallgren-Pettersson C, Ochala J. Ross JA, et al. Among authors: ochala j. Acta Neuropathol. 2019 Sep;138(3):477-495. doi: 10.1007/s00401-019-02034-8. Epub 2019 Jun 19. Acta Neuropathol. 2019. PMID: 31218456 Free PMC article.
NEB mutations disrupt the super-relaxed state of myosin and remodel the muscle metabolic proteome in nemaline myopathy.
Ranu N, Laitila J, Dugdale HF, Mariano J, Kolb JS, Wallgren-Pettersson C, Witting N, Vissing J, Vilchez JJ, Fiorillo C, Zanoteli E, Auranen M, Jokela M, Tasca G, Claeys KG, Voermans NC, Palmio J, Huovinen S, Moggio M, Beck TN, Kontrogianni-Konstantopoulos A, Granzier H, Ochala J. Ranu N, et al. Among authors: ochala j. Acta Neuropathol Commun. 2022 Dec 17;10(1):185. doi: 10.1186/s40478-022-01491-9. Acta Neuropathol Commun. 2022. PMID: 36528760 Free PMC article.
Physical activity impacts resting skeletal muscle myosin conformation and lowers its ATP consumption.
Lewis CTA, Tabrizian L, Nielsen J, Laitila J, Beck TN, Olsen MS, Ognjanovic MM, Aagaard P, Hokken R, Laugesen S, Ingersen A, Andersen JL, Soendenbroe C, Helge JW, Dela F, Larsen S, Sahl RE, Rømer T, Hansen MT, Frandsen J, Suetta C, Ochala J. Lewis CTA, et al. Among authors: ochala j. J Gen Physiol. 2023 Jul 3;155(7):e202213268. doi: 10.1085/jgp.202213268. Epub 2023 May 25. J Gen Physiol. 2023. PMID: 37227464 Free PMC article.
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