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Page 1
IL-4-induced SOX9 confers lineage plasticity to aged adult lung stem cells.
Cai XT, Jia M, Heigl T, Shamir ER, Wong AK, Hall BM, Arlantico A, Hung J, Menon HG, Darmanis S, Brightbill HD, Garfield DA, Rock JR. Cai XT, et al. Among authors: darmanis s. Cell Rep. 2024 Aug 27;43(8):114569. doi: 10.1016/j.celrep.2024.114569. Epub 2024 Jul 31. Cell Rep. 2024. PMID: 39088319 Free article.
Population-wide gene disruption in the murine lung epithelium via AAV-mediated delivery of CRISPR-Cas9 components.
Chen H, Durinck S, Patel H, Foreman O, Mesh K, Eastham J, Caothien R, Newman RJ, Roose-Girma M, Darmanis S, Warming S, Lattanzi A, Liang Y, Haley B. Chen H, et al. Among authors: darmanis s. Mol Ther Methods Clin Dev. 2022 Nov 1;27:431-449. doi: 10.1016/j.omtm.2022.10.016. eCollection 2022 Dec 8. Mol Ther Methods Clin Dev. 2022. PMID: 36419469 Free PMC article.
A myeloid program associated with COVID-19 severity is decreased by therapeutic blockade of IL-6 signaling.
Hackney JA, Shivram H, Vander Heiden J, Overall C, Orozco L, Gao X, Kim E, West N, Qamra A, Chang D, Chakrabarti A, Choy DF, Combes AJ, Courau T, Fragiadakis GK, Rao AA, Ray A, Tsui J, Hu K, Kuhn NF, Krummel MF, Erle DJ, Kangelaris K, Sarma A, Lyon Z, Calfee CS, Woodruff PG, Ghale R, Mick E, Byrne A, Zha BS, Langelier C, Hendrickson CM, van der Wijst MGP, Hartoularos GC, Grant T, Bueno R, Lee DS, Greenland JR, Sun Y, Perez R, Ogorodnikov A, Ward A, Ye CJ; UCSF COMET Consortium; Ramalingam T, McBride JM, Cai F, Teterina A, Bao M, Tsai L, Rosas IO, Regev A, Kapadia SB, Bauer RN, Rosenberger CM. Hackney JA, et al. iScience. 2023 Sep 1;26(10):107813. doi: 10.1016/j.isci.2023.107813. eCollection 2023 Oct 20. iScience. 2023. PMID: 37810211 Free PMC article.
Generation of Schwann cell derived melanocytes from hPSCs identifies pro-metastatic factors in melanoma.
Samuel RM, Navickas A, Maynard A, Gaylord EA, Garcia K, Bhat S, Majd H, Richter MN, Elder N, Le D, Nguyen P, Shibata B, Llabata ML, Selleri L, Laird DJ, Darmanis S, Goodarzi H, Fattahi F. Samuel RM, et al. Among authors: darmanis s. bioRxiv [Preprint]. 2023 Mar 7:2023.03.06.531220. doi: 10.1101/2023.03.06.531220. bioRxiv. 2023. PMID: 36945537 Free PMC article. Preprint.
Impaired immune signaling and changes in the lung microbiome precede secondary bacterial pneumonia in COVID-19.
Tsitsiklis A, Zha BS, Byrne A, Devoe C, Levan S, Rackaityte E, Sunshine S, Mick E, Ghale R, Jauregui A, Sarma A, Neff N, Serpa PH, Deiss TJ, Kistler A, Carrillo S, Ansel KM, Leligdowicz A, Christenson S, Jones N, Wu B, Darmanis S, Matthay MA, Lynch SV, DeRisi JL; COMET Consortium; Hendrickson CM, Kangelaris KN, Krummel MF, Woodruff PG, Erle DJ, Rosenberg O, Calfee CS, Langelier CR. Tsitsiklis A, et al. Among authors: darmanis s. Res Sq [Preprint]. 2021 Apr 23:rs.3.rs-380803. doi: 10.21203/rs.3.rs-380803/v1. Res Sq. 2021. PMID: 34013247 Free PMC article. Preprint.
A comprehensive analysis framework for evaluating commercial single-cell RNA sequencing technologies.
De Simone M, Hoover J, Lau J, Bennett HM, Wu B, Chen C, Menon H, Au-Yeung A, Lear S, Vaidya S, Shi M, Lund JM, Xavier-Magalhães A, Liang Y, Kurdoglu A, O'Gorman WE, Modrusan Z, Le D, Darmanis S. De Simone M, et al. Among authors: darmanis s. Nucleic Acids Res. 2024 Dec 16:gkae1186. doi: 10.1093/nar/gkae1186. Online ahead of print. Nucleic Acids Res. 2024. PMID: 39675380
Induction of a distinct macrophage population and protection from lung injury and fibrosis by Notch2 blockade.
Cruz Tleugabulova M, Melo SP, Wong A, Arlantico A, Liu M, Webster JD, Lau J, Lechner A, Corak B, Hodgins JJ, Garlapati VS, De Simone M, Korin B, Avraham S, Lund J, Jeet S, Reiss A, Bender H, Austin CD, Darmanis S, Modrusan Z, Brightbill H, Durinck S, Diamond MS, Schneider C, Shaw AS, Nitschké M. Cruz Tleugabulova M, et al. Among authors: darmanis s. Nat Commun. 2024 Nov 6;15(1):9575. doi: 10.1038/s41467-024-53700-9. Nat Commun. 2024. PMID: 39505846 Free PMC article.
Overloading And unpacKing (OAK) - droplet-based combinatorial indexing for ultra-high throughput single-cell multiomic profiling.
Wu B, Bennett HM, Ye X, Sridhar A, Eidenschenk C, Everett C, Nazarova EV, Chen HH, Kim IK, Deangelis M, Owen LA, Chen C, Lau J, Shi M, Lund JM, Xavier-Magalhães A, Patel N, Liang Y, Modrusan Z, Darmanis S. Wu B, et al. Among authors: darmanis s. Nat Commun. 2024 Oct 23;15(1):9146. doi: 10.1038/s41467-024-53227-z. Nat Commun. 2024. PMID: 39443484 Free PMC article.
72 results