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Page 1
Structure-guided design of a peripherally restricted chemogenetic system.
Kang HJ, Krumm BE, Tassou A, Geron M, DiBerto JF, Kapolka NJ, Gumpper RH, Sakamoto K, Dewran Kocak D, Olsen RHJ, Huang XP, Zhang S, Huang KL, Zaidi SA, Nguyen MT, Jo MJ, Katritch V, Fay JF, Scherrer G, Roth BL. Kang HJ, et al. Among authors: kapolka nj. Cell. 2024 Dec 26;187(26):7433-7449.e20. doi: 10.1016/j.cell.2024.11.001. Epub 2024 Dec 3. Cell. 2024. PMID: 39631393
A neurodevelopmental disorder mutation locks G proteins in the transitory pre-activated state.
Knight KM, Krumm BE, Kapolka NJ, Ludlam WG, Cui M, Mani S, Prytkova I, Obarow EG, Lefevre TJ, Wei W, Ma N, Huang XP, Fay JF, Vaidehi N, Smrcka AV, Slesinger PA, Logothetis DE, Martemyanov KA, Roth BL, Dohlman HG. Knight KM, et al. Among authors: kapolka nj. Nat Commun. 2024 Aug 5;15(1):6643. doi: 10.1038/s41467-024-50964-z. Nat Commun. 2024. PMID: 39103320 Free PMC article.
Development of a Peripherally Restricted 5-HT2B Partial Agonist for Treatment of Pulmonary Arterial Hypertension.
Valentine MS, Bender AM, Shay S, Paffenroth KC, Gladson S, Dickerson JW, Watson KJ, Kapolka NJ, Boutaud O, Rook JM, Blackwell TS, Roth BL, Harrison FE, Austin ED, West JD, Lindsley CW, Merryman WD. Valentine MS, et al. Among authors: kapolka nj. JACC Basic Transl Sci. 2023 Sep 13;8(10):1379-1388. doi: 10.1016/j.jacbts.2023.06.014. eCollection 2023 Oct. JACC Basic Transl Sci. 2023. PMID: 38094686 Free PMC article.
The evolution and mechanism of GPCR proton sensing.
Rowe JB, Kapolka NJ, Taghon GJ, Morgan WM, Isom DG. Rowe JB, et al. Among authors: kapolka nj. J Biol Chem. 2021 Jan-Jun;296:100167. doi: 10.1074/jbc.RA120.016352. Epub 2020 Dec 13. J Biol Chem. 2021. PMID: 33478938 Free PMC article.
HCAR3: an underexplored metabolite sensor.
Kapolka NJ, Isom DG. Kapolka NJ, et al. Nat Rev Drug Discov. 2020 Nov;19(11):745. doi: 10.1038/d41573-020-00173-2. Nat Rev Drug Discov. 2020. PMID: 33009526 Free PMC article. No abstract available.
13 results