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Page 1
A neurodevelopmental disorder mutation locks G proteins in the transitory pre-activated state.
Knight KM, Krumm BE, Kapolka NJ, Ludlam WG, Cui M, Mani S, Prytkova I, Obarow EG, Lefevre TJ, Wei W, Ma N, Huang XP, Fay JF, Vaidehi N, Smrcka AV, Slesinger PA, Logothetis DE, Martemyanov KA, Roth BL, Dohlman HG. Knight KM, et al. Among authors: ludlam wg. Nat Commun. 2024 Aug 5;15(1):6643. doi: 10.1038/s41467-024-50964-z. Nat Commun. 2024. PMID: 39103320 Free PMC article.
Diverse faces of GNAO1: mild forms in epilepsy and autism.
Ludlam WG, Soliani L, Domínguez-Carral J, Cordelli DM, Marchiani V, Gorría-Redondo N, Aguilera-Albesa S, Martemyanov KA, Ortigoza-Escobar JD. Ludlam WG, et al. J Neurol. 2024 Jul;271(7):3777-3781. doi: 10.1007/s00415-024-12418-w. Epub 2024 May 10. J Neurol. 2024. PMID: 38724739 No abstract available.
Severity of GNAO1-Related Disorder Correlates with Changes in G-Protein Function.
Domínguez-Carral J, Ludlam WG, Junyent Segarra M, Fornaguera Marti M, Balsells S, Muchart J, Čokolić Petrović D, Espinoza I, Ortigoza-Escobar JD, Martemyanov KA; GNAO1-Study Group. Domínguez-Carral J, et al. Among authors: ludlam wg. Ann Neurol. 2023 Nov;94(5):987-1004. doi: 10.1002/ana.26758. Epub 2023 Aug 31. Ann Neurol. 2023. PMID: 37548038 Free PMC article.
Visualizing the chaperone-mediated folding trajectory of the G protein β5 β-propeller.
Wang S, Sass MI, Kwon Y, Ludlam WG, Smith TM, Carter EJ, Gladden NE, Riggi M, Iwasa JH, Willardson BM, Shen PS. Wang S, et al. Among authors: ludlam wg. bioRxiv [Preprint]. 2023 May 4:2023.05.04.539424. doi: 10.1101/2023.05.04.539424. bioRxiv. 2023. Update in: Mol Cell. 2023 Nov 2;83(21):3852-3868.e6. doi: 10.1016/j.molcel.2023.09.032 PMID: 37205387 Free PMC article. Updated. Preprint.
Molecular architecture of the Bardet-Biedl syndrome protein 2-7-9 subcomplex.
Ludlam WG, Aoba T, Cuéllar J, Bueno-Carrasco MT, Makaju A, Moody JD, Franklin S, Valpuesta JM, Willardson BM. Ludlam WG, et al. J Biol Chem. 2019 Nov 1;294(44):16385-16399. doi: 10.1074/jbc.RA119.010150. Epub 2019 Sep 17. J Biol Chem. 2019. PMID: 31530639 Free PMC article.