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Oligodendrocytes produce amyloid-β and contribute to plaque formation alongside neurons in Alzheimer's disease model mice.
Sasmita AO, Depp C, Nazarenko T, Sun T, Siems SB, Ong EC, Nkeh YB, Böhler C, Yu X, Bues B, Evangelista L, Mao S, Morgado B, Wu Z, Ruhwedel T, Subramanian S, Börensen F, Overhoff K, Spieth L, Berghoff SA, Sadleir KR, Vassar R, Eggert S, Goebbels S, Saito T, Saido T, Saher G, Möbius W, Castelo-Branco G, Klafki HW, Wirths O, Wiltfang J, Jäkel S, Yan R, Nave KA. Sasmita AO, et al. Among authors: saito t. Nat Neurosci. 2024 Sep;27(9):1668-1674. doi: 10.1038/s41593-024-01730-3. Epub 2024 Aug 5. Nat Neurosci. 2024. PMID: 39103558 Free PMC article.
[Presymptomatic diagnosis, prevention and therapy].
Iwata N, Higuchi M, Saito T, Saido TC. Iwata N, et al. Among authors: saito t. No To Shinkei. 2005 Oct;57(10):855-66. No To Shinkei. 2005. PMID: 16277230 Japanese. No abstract available.
Potent amyloidogenicity and pathogenicity of Aβ43.
Saito T, Suemoto T, Brouwers N, Sleegers K, Funamoto S, Mihira N, Matsuba Y, Yamada K, Nilsson P, Takano J, Nishimura M, Iwata N, Van Broeckhoven C, Ihara Y, Saido TC. Saito T, et al. Nat Neurosci. 2011 Jul 3;14(8):1023-32. doi: 10.1038/nn.2858. Nat Neurosci. 2011. PMID: 21725313
Cell surface expression of the major amyloid-β peptide (Aβ)-degrading enzyme, neprilysin, depends on phosphorylation by mitogen-activated protein kinase/extracellular signal-regulated kinase kinase (MEK) and dephosphorylation by protein phosphatase 1a.
Kakiya N, Saito T, Nilsson P, Matsuba Y, Tsubuki S, Takei N, Nawa H, Saido TC. Kakiya N, et al. Among authors: saito t. J Biol Chem. 2012 Aug 24;287(35):29362-72. doi: 10.1074/jbc.M112.340372. Epub 2012 Jul 5. J Biol Chem. 2012. PMID: 22767595 Free PMC article.
Aβ secretion and plaque formation depend on autophagy.
Nilsson P, Loganathan K, Sekiguchi M, Matsuba Y, Hui K, Tsubuki S, Tanaka M, Iwata N, Saito T, Saido TC. Nilsson P, et al. Among authors: saito t. Cell Rep. 2013 Oct 17;5(1):61-9. doi: 10.1016/j.celrep.2013.08.042. Epub 2013 Oct 3. Cell Rep. 2013. PMID: 24095740 Free article.
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