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Single-Cell Analyses Reveal Diverse Mechanisms of Resistance to EGFR Tyrosine Kinase Inhibitors in Lung Cancer.
Kashima Y, Shibahara D, Suzuki A, Muto K, Kobayashi IS, Plotnick D, Udagawa H, Izumi H, Shibata Y, Tanaka K, Fujii M, Ohashi A, Seki M, Goto K, Tsuchihara K, Suzuki Y, Kobayashi SS. Kashima Y, et al. Among authors: kobayashi is. Cancer Res. 2021 Sep 15;81(18):4835-4848. doi: 10.1158/0008-5472.CAN-20-2811. Epub 2021 Jul 9. Cancer Res. 2021. PMID: 34247147 Free PMC article.
EGFR-A763_Y764insFQEA Is a Unique Exon 20 Insertion Mutation That Displays Sensitivity to Approved and In-Development Lung Cancer EGFR Tyrosine Kinase Inhibitors.
Vasconcelos PENS, Gergis C, Viray H, Varkaris A, Fujii M, Rangachari D, VanderLaan PA, Kobayashi IS, Kobayashi SS, Costa DB. Vasconcelos PENS, et al. Among authors: kobayashi is. JTO Clin Res Rep. 2020 Sep;1(3):100051. doi: 10.1016/j.jtocrr.2020.100051. Epub 2020 May 13. JTO Clin Res Rep. 2020. PMID: 34104899 Free PMC article.
TIP60 is required for tumorigenesis in non-small cell lung cancer.
Shibahara D, Akanuma N, Kobayashi IS, Heo E, Ando M, Fujii M, Jiang F, Prin PN, Pan G, Wong KK, Costa DB, Bararia D, Tenen DG, Watanabe H, Kobayashi SS. Shibahara D, et al. Among authors: kobayashi is. Cancer Sci. 2023 Jun;114(6):2400-2413. doi: 10.1111/cas.15785. Epub 2023 Apr 18. Cancer Sci. 2023. PMID: 36916958 Free PMC article.
EGFR exon 19 insertion EGFR-K745_E746insIPVAIK and others with rare XPVAIK amino-acid insertions: Preclinical and clinical characterization of the favorable therapeutic window to all classes of approved EGFR kinase inhibitors.
Shaffer W, Kobayashi IS, Sentana-Lledo D, Sundararaman S, Lee MD, Rangachari D, VanderLaan PA, Kobayashi SS, Costa DB. Shaffer W, et al. Among authors: kobayashi is. Lung Cancer. 2023 Jul;181:107250. doi: 10.1016/j.lungcan.2023.107250. Epub 2023 May 13. Lung Cancer. 2023. PMID: 37196448 Free PMC article.
Suppression of multiple anti-apoptotic BCL2 family proteins recapitulates the effects of JAK2 inhibitors in JAK2V617F driven myeloproliferative neoplasms.
Takei H, Coelho-Silva JL, Tavares Leal C, Queiroz Arantes Rocha A, Mantello Bianco T, Welner RS, Mishima Y, Kobayashi IS, Mullally A, Lima K, Machado-Neto JA, Kobayashi SS, Lobo de Figueiredo-Pontes L. Takei H, et al. Among authors: kobayashi is. Cancer Sci. 2022 Feb;113(2):597-608. doi: 10.1111/cas.15210. Epub 2021 Dec 15. Cancer Sci. 2022. PMID: 34808021 Free PMC article.
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