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An ultra-early, transient interferon-associated innate immune response associates with protection from SARS-CoV-2 infection despite exposure.
Fenn J, Madon K, Conibear E, Derelle R, Nevin S, Kundu R, Hakki S, Tregoning JS, Koycheva A, Derqui N, Tolosa-Wright M, Jonnerby J, Wang L, Baldwin S, Pillay TD, Thwaites RS, Luca C, Varro R, Badhan A, Parker E, Rosadas C, McClure M, Tedder R, Taylor G, Lalvani A; INSTINCT Study Investigators. Fenn J, et al. EBioMedicine. 2024 Dec 11;111:105475. doi: 10.1016/j.ebiom.2024.105475. Online ahead of print. EBioMedicine. 2024. PMID: 39667271 Free article.
Impaired antiviral immunity in frequent exacerbators of chronic obstructive pulmonary disease.
Finney LJ, Fenwick P, Kemp SV, Singanayagam A, Edwards MR, Belchamber KBR, Kebadze T, Regis E, Donaldson GD, Mallia P, Donnelly LE, Johnston SL, Wedzicha JA. Finney LJ, et al. Among authors: singanayagam a. Am J Physiol Lung Cell Mol Physiol. 2025 Jan 1;328(1):L120-L133. doi: 10.1152/ajplung.00118.2024. Epub 2024 Nov 19. Am J Physiol Lung Cell Mol Physiol. 2025. PMID: 39560620
Neutrophil extracellular traps promote immunopathogenesis of virus-induced COPD exacerbations.
Katsoulis O, Toussaint M, Jackson MM, Mallia P, Footitt J, Mincham KT, Meyer GFM, Kebadze T, Gilmour A, Long M, Aswani AD, Snelgrove RJ, Johnston SL, Chalmers JD, Singanayagam A. Katsoulis O, et al. Among authors: singanayagam a. Nat Commun. 2024 Jul 9;15(1):5766. doi: 10.1038/s41467-024-50197-0. Nat Commun. 2024. PMID: 38982052 Free PMC article.
Obesity dysregulates the pulmonary antiviral immune response.
Almond M, Farne HA, Jackson MM, Jha A, Katsoulis O, Pitts O, Tunstall T, Regis E, Dunning J, Byrne AJ, Mallia P, Kon OM, Saunders KA, Simpson KD, Snelgrove RJ, Openshaw PJM, Edwards MR, Barclay WS, Heaney LM, Johnston SL, Singanayagam A. Almond M, et al. Among authors: singanayagam a. Nat Commun. 2023 Oct 19;14(1):6607. doi: 10.1038/s41467-023-42432-x. Nat Commun. 2023. PMID: 37857661 Free PMC article.
Increased reports of severe myocarditis associated with enterovirus infection in neonates, United Kingdom, 27 June 2022 to 26 April 2023.
Singanayagam A, Moore C, Froude S, Celma C, Stowe J, Hani E, Ng KF, Muir P, Roderick M, Cottrell S, Bibby DF, Vipond B, Gillett S, Davis PJ, Gibb J, Barry M, Harris P, Rowley F, Song J, Shankar AG, McMichael D, Cohen JM, Manian A, Harvey C, Primrose LS, Wilson S, Bradley DT, Paranthaman K, Beard S, Zambon M, Ramsay M, Saliba V, Ladhani S, Williams C. Singanayagam A, et al. Euro Surveill. 2023 Sep;28(39):2300313. doi: 10.2807/1560-7917.ES.2023.28.39.2300313. Euro Surveill. 2023. PMID: 37768558 Free PMC article.
154 results