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Advancing research and development of anti-infectives for children with a focus on antiretroviral therapy: A clinical development perspective.
Buchanan AM, Bekker A, Chandasana H, DeMasi R, Lulic Z, Ernest T, Brothers C, Min S, Ruel T, Tan LK. Buchanan AM, et al. Among authors: ruel t. Int J Antimicrob Agents. 2024 Oct;64(4):107306. doi: 10.1016/j.ijantimicag.2024.107306. Epub 2024 Aug 13. Int J Antimicrob Agents. 2024. PMID: 39146996 Free article. Review.
Advancing the prevention and treatment of HIV in children: priorities for research and development.
Penazzato M, Townsend CL, Sam-Agudu NA, Ruel TD, Archary M, Bekker A, Cressey TR, Colbers A, Sugandhi N, Rojo P, Rakhmanina N, Watkins M, Frigati L, Mukui I, Hafiz A, Vicari M, Capparelli EV, Abrams EJ; PADO-HIV 5 participants. Penazzato M, et al. Lancet HIV. 2022 Sep;9(9):e658-e666. doi: 10.1016/S2352-3018(22)00101-1. Epub 2022 Jul 18. Lancet HIV. 2022. PMID: 35863362 Review.
Pharmacokinetics, safety, tolerability, and antiviral activity of dolutegravir dispersible tablets in infants and children with HIV-1 (IMPAACT P1093): results of an open-label, phase 1-2 trial.
Ruel TD, Acosta EP, Liu JP, Gray KP, George K, Montañez N, Popson S, Buchanan AM, Bartlett M, Dayton D, Anthony P, Brothers C, Vavro C, Singh R, Koech L, Vhembo T, Mmbaga BT, Pinto JA, Dobbels EFM, Archary M, Chokephaibulkit K, Ounchanum P, Deville JG, Hazra R, Townley E, Wiznia A; IMPAACT P1093 team. Ruel TD, et al. Lancet HIV. 2022 May;9(5):e332-e340. doi: 10.1016/S2352-3018(22)00044-3. Lancet HIV. 2022. PMID: 35489377 Free PMC article. Clinical Trial.
What babies need: accelerating access to current and novel antiretroviral drugs in neonates through pharmacokinetic studies.
Jacobs TG, Schouwenburg S, Penazzato M, Archary M, Ruel TD, van den Anker J, Burger DM, Cressey TR, Abrams EJ, Lyall H, Bekker A, Colbers A; Penta Clinical Pharmacology Working Group; PADO-HIV 5 participants. Jacobs TG, et al. Lancet HIV. 2022 Sep;9(9):e649-e657. doi: 10.1016/S2352-3018(22)00121-7. Epub 2022 Jul 18. Lancet HIV. 2022. PMID: 35863363 Review.
Pharmacokinetics and safety of early nevirapine-based antiretroviral therapy for neonates at high risk for perinatal HIV infection: a phase 1/2 proof of concept study.
Ruel TD, Capparelli EV, Tierney C, Nelson BS, Coletti A, Bryson Y, Cotton MF, Spector SA, Mirochnick M, LeBlanc R, Reding C, Zimmer B, Persaud D, Bwakura-Dangarembizi M, Naidoo KL, Hazra R, Jean-Philippe P, Chadwick EG. Ruel TD, et al. Lancet HIV. 2021 Mar;8(3):e149-e157. doi: 10.1016/S2352-3018(20)30274-5. Epub 2020 Nov 23. Lancet HIV. 2021. PMID: 33242457 Free PMC article. Clinical Trial.
Prioritising the most needed paediatric antiretroviral formulations: the PADO4 list.
Penazzato M, Townsend CL, Rakhmanina N, Cheng Y, Archary M, Cressey TR, Kim MH, Musiime V, Turkova A, Ruel TD, Rabie H, Sugandhi N, Rojo P, Doherty M, Abrams EJ; PADO4 participants. Penazzato M, et al. Lancet HIV. 2019 Sep;6(9):e623-e631. doi: 10.1016/S2352-3018(19)30193-6. Lancet HIV. 2019. PMID: 31498110 Review.
High rates of viral suppression in adults and children with high CD4+ counts using a streamlined ART delivery model in the SEARCH trial in rural Uganda and Kenya.
Kwarisiima D, Kamya MR, Owaraganise A, Mwangwa F, Byonanebye DM, Ayieko J, Plenty A, Black D, Clark TD, Nzarubara B, Snyman K, Brown L, Bukusi E, Cohen CR, Geng EH, Charlebois ED, Ruel TD, Petersen ML, Havlir D, Jain V. Kwarisiima D, et al. J Int AIDS Soc. 2017 Jul 21;20(Suppl 4):21673. doi: 10.7448/IAS.20.5.21673. J Int AIDS Soc. 2017. PMID: 28770596 Free PMC article. Clinical Trial.
99 results