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The clinical-stage drug BTZ-043 accumulates in murine tuberculosis lesions and efficiently acts against Mycobacterium tuberculosis.
Römpp A, Treu A, Kokesch-Himmelreich J, Marwitz F, Dreisbach J, Aboutara N, Hillemann D, Garrelts M, Converse PJ, Tyagi S, Gerbach S, Gyr L, Lemm AK, Volz J, Hölscher A, Gröschel L, Stemp EM, Heinrich N, Kloss F, Nuermberger EL, Schwudke D, Hoelscher M, Hölscher C, Walter K. Römpp A, et al. Among authors: schwudke d. Nat Commun. 2025 Jan 18;16(1):826. doi: 10.1038/s41467-025-56146-9. Nat Commun. 2025. PMID: 39827265 Free PMC article.
A Comparative Pharmacokinetics Study of Orally and Intranasally Administered 8-Nitro-1,3-benzothiazin-4-one (BTZ043) Amorphous Drug Nanoparticles.
Li F, Marwitz F, Rudolph D, Gauda W, Cohrs M, Neumann PR, Lucas H, Kollan J, Tahir A, Schwudke D, Feldmann C, Hädrich G, Dailey LA. Li F, et al. Among authors: schwudke d. ACS Pharmacol Transl Sci. 2024 Nov 9;7(12):4123-4134. doi: 10.1021/acsptsci.4c00558. eCollection 2024 Dec 13. ACS Pharmacol Transl Sci. 2024. PMID: 39698258
The lipidomics reporting checklist a framework for transparency of lipidomic experiments and repurposing resource data.
Kopczynski D, Ejsing CS, McDonald JG, Bamba T, Baker ES, Bertrand-Michel J, Brügger B, Coman C, Ellis SR, Garrett TJ, Griffiths WJ, Guan XL, Han X, Höring M, Holčapek M, Hoffmann N, Huynh K, Lehmann R, Jones JW, Kaddurah-Daouk R, Köfeler HC, Meikle PJ, Metz TO, O'Donnell VB, Saigusa D, Schwudke D, Shevchenko A, Torta F, Vizcaíno JA, Welti R, Wenk MR, Wolrab D, Xia Y, Ekroos K, Ahrends R, Liebisch G. Kopczynski D, et al. Among authors: schwudke d. J Lipid Res. 2024 Sep;65(9):100621. doi: 10.1016/j.jlr.2024.100621. Epub 2024 Aug 14. J Lipid Res. 2024. PMID: 39151590 Free PMC article.
Intranasal Administration of Bedaquiline-Loaded Fucosylated Liposomes Provides Anti-Tubercular Activity while Reducing the Potential for Systemic Side Effects.
Marwitz F, Hädrich G, Redinger N, Besecke KFW, Li F, Aboutara N, Thomsen S, Cohrs M, Neumann PR, Lucas H, Kollan J, Hozsa C, Gieseler RK, Schwudke D, Furch M, Schaible U, Dailey LA. Marwitz F, et al. Among authors: schwudke d. ACS Infect Dis. 2024 Sep 13;10(9):3222-3232. doi: 10.1021/acsinfecdis.4c00192. Epub 2024 Aug 13. ACS Infect Dis. 2024. PMID: 39136125 Free PMC article.
Global analysis of putative phospholipases in Plasmodium falciparum reveals an essential role of the phosphoinositide-specific phospholipase C in parasite maturation.
Burda PC, Ramaprasad A, Bielfeld S, Pietsch E, Woitalla A, Söhnchen C, Singh MN, Strauss J, Sait A, Collinson LM, Schwudke D, Blackman MJ, Gilberger TW. Burda PC, et al. Among authors: schwudke d. mBio. 2023 Aug 31;14(4):e0141323. doi: 10.1128/mbio.01413-23. Epub 2023 Jul 25. mBio. 2023. PMID: 37489900 Free PMC article.
Longitudinal gut microbiome analyses and blooms of pathogenic strains during lupus disease flares.
Azzouz DF, Chen Z, Izmirly PM, Chen LA, Li Z, Zhang C, Mieles D, Trujillo K, Heguy A, Pironti A, Putzel GG, Schwudke D, Fenyo D, Buyon JP, Alekseyenko AV, Gisch N, Silverman GJ. Azzouz DF, et al. Among authors: schwudke d. Ann Rheum Dis. 2023 Oct;82(10):1315-1327. doi: 10.1136/ard-2023-223929. Epub 2023 Jun 26. Ann Rheum Dis. 2023. PMID: 37365013 Free PMC article.
A Single Residue within the MCR-1 Protein Confers Anticipatory Resilience.
Frantz R, Gwozdzinski K, Gisch N, Doijad SP, Hudel M, Wille M, Abu Mraheil M, Schwudke D, Imirzalioglu C, Falgenhauer L, Ehrmann M, Chakraborty T. Frantz R, et al. Among authors: schwudke d. Microbiol Spectr. 2023 Jun 15;11(3):e0359222. doi: 10.1128/spectrum.03592-22. Epub 2023 Apr 18. Microbiol Spectr. 2023. PMID: 37071007 Free PMC article.
94 results