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Initial Pharmacological Characterization of a Major Hydroxy Metabolite of PF-5190457: Inverse Agonist Activity of PF-6870961 at the Ghrelin Receptor.
Deschaine SL, Hedegaard MA, Pince CL, Farokhnia M, Moose JE, Stock IA, Adusumalli S, Akhlaghi F, Hougland JL, Sulima A, Rice KC, Koob GF, Vendruscolo LF, Holst B, Leggio L. Deschaine SL, et al. Among authors: leggio l. J Pharmacol Exp Ther. 2023 Aug;386(2):117-128. doi: 10.1124/jpet.122.001393. Epub 2023 Jan 11. J Pharmacol Exp Ther. 2023. PMID: 36631279 Free PMC article.
Role of aldosterone and mineralocorticoid receptor (MR) in addiction: A scoping review.
Pince CL, Whiting KE, Wang T, Lékó AH, Farinelli LA, Cooper D, Farokhnia M, Vendruscolo LF, Leggio L. Pince CL, et al. Among authors: leggio l. Neurosci Biobehav Rev. 2023 Nov;154:105427. doi: 10.1016/j.neubiorev.2023.105427. Epub 2023 Oct 17. Neurosci Biobehav Rev. 2023. PMID: 37858908 Free PMC article. Review.
Genetic or pharmacological GHSR blockade has sexually dimorphic effects in rodents on a high-fat diet.
Leggio L, Leko A, Gregory-Flores A, Marchette R, Gomez J, Vendruscolo J, Repunte-Canonigo V, Chuong V, Deschaine S, Whiting K, Jackson S, Cornejo M, Perello M, You ZB, Eckhaus M, Janda K, Zorman B, Sumazin P, Koob G, Michaelides M, Sanna PP, Vendruscolo L. Leggio L, et al. Res Sq [Preprint]. 2023 Oct 18:rs.3.rs-3236045. doi: 10.21203/rs.3.rs-3236045/v1. Res Sq. 2023. Update in: Commun Biol. 2024 May 25;7(1):632. doi: 10.1038/s42003-024-06303-5 PMID: 37886546 Free PMC article. Updated. Preprint.
A randomized, double-blind, placebo-controlled study of a GHSR blocker in people with alcohol use disorder.
Faulkner ML, Farokhnia M, Lee MR, Farinelli L, Browning BD, Abshire K, Daurio AM, Munjal V, Deschaine SL, Boukabara SR, Fortney C, Sherman G, Schwandt M, Akhlaghi F, Momenan R, Ross TJ, Persky S, Leggio L. Faulkner ML, et al. Among authors: leggio l. JCI Insight. 2024 Dec 20;9(24):e182331. doi: 10.1172/jci.insight.182331. JCI Insight. 2024. PMID: 39704175 Free PMC article. Clinical Trial.
478 results