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METI: deep profiling of tumor ecosystems by integrating cell morphology and spatial transcriptomics.
Jiang J, Liu Y, Qin J, Chen J, Wu J, Pizzi MP, Lazcano R, Yamashita K, Xu Z, Pei G, Cho KS, Chu Y, Sinjab A, Peng F, Yan X, Han G, Wang R, Dai E, Dai Y, Czerniak BA, Futreal A, Maitra A, Lazar A, Kadara H, Jazaeri AA, Cheng X, Ajani J, Gao J, Hu J, Wang L. Jiang J, et al. Among authors: czerniak ba. Nat Commun. 2024 Aug 25;15(1):7312. doi: 10.1038/s41467-024-51708-9. Nat Commun. 2024. PMID: 39181865 Free PMC article.
9p21 loss confers a cold tumor immune microenvironment and primary resistance to immune checkpoint therapy.
Han G, Yang G, Hao D, Lu Y, Thein K, Simpson BS, Chen J, Sun R, Alhalabi O, Wang R, Dang M, Dai E, Zhang S, Nie F, Zhao S, Guo C, Hamza A, Czerniak B, Cheng C, Siefker-Radtke A, Bhat K, Futreal A, Peng G, Wargo J, Peng W, Kadara H, Ajani J, Swanton C, Litchfield K, Ahnert JR, Gao J, Wang L. Han G, et al. Nat Commun. 2021 Sep 23;12(1):5606. doi: 10.1038/s41467-021-25894-9. Nat Commun. 2021. PMID: 34556668 Free PMC article.
MTAP deficiency creates an exploitable target for antifolate therapy in 9p21-loss cancers.
Alhalabi O, Chen J, Zhang Y, Lu Y, Wang Q, Ramachandran S, Tidwell RS, Han G, Yan X, Meng J, Wang R, Hoang AG, Wang WL, Song J, Lopez L, Andreev-Drakhlin A, Siefker-Radtke A, Zhang X, Benedict WF, Shah AY, Wang J, Msaouel P, Zhang M, Guo CC, Czerniak B, Behrens C, Soto L, Papadimitrakopoulou V, Lewis J, Rinsurongkawong W, Rinsurongkawong V, Lee J, Roth J, Swisher S, Wistuba I, Heymach J, Wang J, Campbell MT, Efstathiou E, Titus M, Logothetis CJ, Ho TH, Zhang J, Wang L, Gao J. Alhalabi O, et al. Nat Commun. 2022 Apr 4;13(1):1797. doi: 10.1038/s41467-022-29397-z. Nat Commun. 2022. PMID: 35379845 Free PMC article. Clinical Trial.
Estimation of tumor cell total mRNA expression in 15 cancer types predicts disease progression.
Cao S, Wang JR, Ji S, Yang P, Dai Y, Guo S, Montierth MD, Shen JP, Zhao X, Chen J, Lee JJ, Guerrero PA, Spetsieris N, Engedal N, Taavitsainen S, Yu K, Livingstone J, Bhandari V, Hubert SM, Daw NC, Futreal PA, Efstathiou E, Lim B, Viale A, Zhang J, Nykter M, Czerniak BA, Brown PH, Swanton C, Msaouel P, Maitra A, Kopetz S, Campbell P, Speed TP, Boutros PC, Zhu H, Urbanucci A, Demeulemeester J, Van Loo P, Wang W. Cao S, et al. Among authors: czerniak ba. Nat Biotechnol. 2022 Nov;40(11):1624-1633. doi: 10.1038/s41587-022-01342-x. Epub 2022 Jun 13. Nat Biotechnol. 2022. PMID: 35697807 Free PMC article.
Spatial Organization and Molecular Correlation of Tumor-Infiltrating Lymphocytes Using Deep Learning on Pathology Images.
Saltz J, Gupta R, Hou L, Kurc T, Singh P, Nguyen V, Samaras D, Shroyer KR, Zhao T, Batiste R, Van Arnam J; Cancer Genome Atlas Research Network; Shmulevich I, Rao AUK, Lazar AJ, Sharma A, Thorsson V. Saltz J, et al. Cell Rep. 2018 Apr 3;23(1):181-193.e7. doi: 10.1016/j.celrep.2018.03.086. Cell Rep. 2018. PMID: 29617659 Free PMC article.
Integrated Genomic Analysis of the Ubiquitin Pathway across Cancer Types.
Ge Z, Leighton JS, Wang Y, Peng X, Chen Z, Chen H, Sun Y, Yao F, Li J, Zhang H, Liu J, Shriver CD, Hu H; Cancer Genome Atlas Research Network; Piwnica-Worms H, Ma L, Liang H. Ge Z, et al. Cell Rep. 2018 Apr 3;23(1):213-226.e3. doi: 10.1016/j.celrep.2018.03.047. Cell Rep. 2018. PMID: 29617661 Free PMC article.
Rosiglitazone and trametinib exhibit potent anti-tumor activity in a mouse model of muscle invasive bladder cancer.
Plumber SA, Tate T, Al-Ahmadie H, Chen X, Choi W, Basar M, Lu C, Viny A, Batourina E, Li J, Gretarsson K, Alija B, Molotkov A, Wiessner G, Lee BHL, McKiernan J, McConkey DJ, Dinney C, Czerniak B, Mendelsohn CL. Plumber SA, et al. Nat Commun. 2024 Aug 2;15(1):6538. doi: 10.1038/s41467-024-50678-2. Nat Commun. 2024. PMID: 39095358 Free PMC article.
The molecular pathology of sarcomas.
Powers M, Zhang W, Lopez-Terrada D, Czerniak BA, Lazar AJ. Powers M, et al. Among authors: czerniak ba. Cancer Biomark. 2010;9(1-6):475-91. doi: 10.3233/CBM-2011-0170. Cancer Biomark. 2010. PMID: 22112491
191 results