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EWS-WT1 fusion isoforms establish oncogenic programs and therapeutic vulnerabilities in desmoplastic small round cell tumors.
Boulay G, Broye LC, Dong R, Iyer S, Sanalkumar R, Xing YH, Buisson R, Rengarajan S, Naigles B, Duc B, Volorio A, Awad ME, Renella R, Chebib I, Nielsen GP, Choy E, Cote GM, Zou L, Letovanec I, Stamenkovic I, Rivera MN, Riggi N. Boulay G, et al. Among authors: iyer s. Nat Commun. 2024 Aug 28;15(1):7460. doi: 10.1038/s41467-024-51851-3. Nat Commun. 2024. PMID: 39198430 Free PMC article.
LIN28B Underlies the Pathogenesis of a Subclass of Ewing Sarcoma LIN28B Control of EWS-FLI1 Stability.
Keskin T, Bakaric A, Waszyk P, Boulay G, Torsello M, Cornaz-Buros S, Chevalier N, Geiser T, Martin P, Volorio A, Iyer S, Kulkarni A, Letovanec I, Cherix S, Cote GM, Choy E, Digklia A, Montemurro M, Chebib I, Nielsen PG, Carcaboso AM, Mora J, Renella R, Suvà ML, Fusco C, Provero P, Rivera MN, Riggi N, Stamenkovic I. Keskin T, et al. Among authors: iyer s. Cell Rep. 2020 Mar 31;30(13):4567-4583.e5. doi: 10.1016/j.celrep.2019.12.053. Cell Rep. 2020. PMID: 32234488 Free article.
EWSR1-ATF1 dependent 3D connectivity regulates oncogenic and differentiation programs in Clear Cell Sarcoma.
Möller E, Praz V, Rajendran S, Dong R, Cauderay A, Xing YH, Lee L, Fusco C, Broye LC, Cironi L, Iyer S, Rengarajan S, Awad ME, Naigles B, Letovanec I, Ormas N, Finzi G, La Rosa S, Sessa F, Chebib I, Petur Nielsen G, Digklia A, Spentzos D, Cote GM, Choy E, Aryee M, Stamenkovic I, Boulay G, Rivera MN, Riggi N. Möller E, et al. Among authors: iyer s. Nat Commun. 2022 Apr 27;13(1):2267. doi: 10.1038/s41467-022-29910-4. Nat Commun. 2022. PMID: 35477713 Free PMC article.
Highly connected 3D chromatin networks established by an oncogenic fusion protein shape tumor cell identity.
Sanalkumar R, Dong R, Lee L, Xing YH, Iyer S, Letovanec I, La Rosa S, Finzi G, Musolino E, Papait R, Chebib I, Nielsen GP, Renella R, Cote GM, Choy E, Aryee M, Stegmaier K, Stamenkovic I, Rivera MN, Riggi N. Sanalkumar R, et al. Among authors: iyer s. Sci Adv. 2023 Mar 31;9(13):eabo3789. doi: 10.1126/sciadv.abo3789. Epub 2023 Mar 31. Sci Adv. 2023. PMID: 37000878 Free PMC article.
OTX2 Activity at Distal Regulatory Elements Shapes the Chromatin Landscape of Group 3 Medulloblastoma.
Boulay G, Awad ME, Riggi N, Archer TC, Iyer S, Boonseng WE, Rossetti NE, Naigles B, Rengarajan S, Volorio A, Kim JC, Mesirov JP, Tamayo P, Pomeroy SL, Aryee MJ, Rivera MN. Boulay G, et al. Among authors: iyer s. Cancer Discov. 2017 Mar;7(3):288-301. doi: 10.1158/2159-8290.CD-16-0844. Epub 2017 Feb 17. Cancer Discov. 2017. PMID: 28213356 Free PMC article.
Cancer-Specific Retargeting of BAF Complexes by a Prion-like Domain.
Boulay G, Sandoval GJ, Riggi N, Iyer S, Buisson R, Naigles B, Awad ME, Rengarajan S, Volorio A, McBride MJ, Broye LC, Zou L, Stamenkovic I, Kadoch C, Rivera MN. Boulay G, et al. Among authors: iyer s. Cell. 2017 Sep 21;171(1):163-178.e19. doi: 10.1016/j.cell.2017.07.036. Epub 2017 Aug 24. Cell. 2017. PMID: 28844694 Free PMC article.
The chromatin landscape of primary synovial sarcoma organoids is linked to specific epigenetic mechanisms and dependencies.
Boulay G, Cironi L, Garcia SP, Rengarajan S, Xing YH, Lee L, Awad ME, Naigles B, Iyer S, Broye LC, Keskin T, Cauderay A, Fusco C, Letovanec I, Chebib I, Nielsen PG, Tercier S, Cherix S, Nguyen-Ngoc T, Cote G, Choy E, Provero P, Suvà ML, Rivera MN, Stamenkovic I, Riggi N. Boulay G, et al. Among authors: iyer s. Life Sci Alliance. 2020 Dec 23;4(2):e202000808. doi: 10.26508/lsa.202000808. Print 2021 Feb. Life Sci Alliance. 2020. PMID: 33361335 Free PMC article.
2,539 results