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An increased copy number of glycine decarboxylase (GLDC) associated with psychosis reduces extracellular glycine and impairs NMDA receptor function.
Kambali M, Li Y, Unichenko P, Feria Pliego JA, Yadav R, Liu J, McGuinness P, Cobb JG, Wang M, Nagarajan R, Lyu J, Vongsouthi V, Jackson CJ, Engin E, Coyle JT, Shin J, Hodgson NW, Hensch TK, Talkowski ME, Homanics GE, Bolshakov VY, Henneberger C, Rudolph U. Kambali M, et al. Among authors: engin e. Mol Psychiatry. 2024 Aug 30. doi: 10.1038/s41380-024-02711-5. Online ahead of print. Mol Psychiatry. 2024. PMID: 39210012
Modulation of anxiety and fear via distinct intrahippocampal circuits.
Engin E, Smith KS, Gao Y, Nagy D, Foster RA, Tsvetkov E, Keist R, Crestani F, Fritschy JM, Bolshakov VY, Hajos M, Heldt SA, Rudolph U. Engin E, et al. Elife. 2016 Mar 14;5:e14120. doi: 10.7554/eLife.14120. Elife. 2016. PMID: 26971710 Free PMC article.
An Emerging Circuit Pharmacology of GABAA Receptors.
Engin E, Benham RS, Rudolph U. Engin E, et al. Trends Pharmacol Sci. 2018 Aug;39(8):710-732. doi: 10.1016/j.tips.2018.04.003. Epub 2018 Jun 11. Trends Pharmacol Sci. 2018. PMID: 29903580 Free PMC article. Review.
87 results