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An increased copy number of glycine decarboxylase (GLDC) associated with psychosis reduces extracellular glycine and impairs NMDA receptor function.
Kambali M, Li Y, Unichenko P, Feria Pliego JA, Yadav R, Liu J, McGuinness P, Cobb JG, Wang M, Nagarajan R, Lyu J, Vongsouthi V, Jackson CJ, Engin E, Coyle JT, Shin J, Hodgson NW, Hensch TK, Talkowski ME, Homanics GE, Bolshakov VY, Henneberger C, Rudolph U. Kambali M, et al. Among authors: homanics ge. Mol Psychiatry. 2024 Aug 30. doi: 10.1038/s41380-024-02711-5. Online ahead of print. Mol Psychiatry. 2024. PMID: 39210012
MAP2 is differentially phosphorylated in schizophrenia, altering its function.
Grubisha MJ, Sun X, MacDonald ML, Garver M, Sun Z, Paris KA, Patel DS, DeGiosio RA, Lewis DA, Yates NA, Camacho C, Homanics GE, Ding Y, Sweet RA. Grubisha MJ, et al. Among authors: homanics ge. Mol Psychiatry. 2021 Sep;26(9):5371-5388. doi: 10.1038/s41380-021-01034-z. Epub 2021 Feb 1. Mol Psychiatry. 2021. PMID: 33526823 Free PMC article.
Ethanol's interaction with BK channel α subunit residue K361 does not mediate behavioral responses to alcohol in mice.
Okhuarobo A, Kreifeldt M, Gandhi PJ, Lopez C, Martinez B, Fleck K, Bajo M, Bhattacharyya P, Dopico AM, Roberto M, Roberts AJ, Homanics GE, Contet C. Okhuarobo A, et al. Among authors: homanics ge. Mol Psychiatry. 2024 Feb;29(2):529-542. doi: 10.1038/s41380-023-02346-y. Epub 2023 Dec 22. Mol Psychiatry. 2024. PMID: 38135755 Free PMC article.
GABAA receptor alpha 4 subunits mediate extrasynaptic inhibition in thalamus and dentate gyrus and the action of gaboxadol.
Chandra D, Jia F, Liang J, Peng Z, Suryanarayanan A, Werner DF, Spigelman I, Houser CR, Olsen RW, Harrison NL, Homanics GE. Chandra D, et al. Among authors: homanics ge. Proc Natl Acad Sci U S A. 2006 Oct 10;103(41):15230-5. doi: 10.1073/pnas.0604304103. Epub 2006 Sep 27. Proc Natl Acad Sci U S A. 2006. PMID: 17005728 Free PMC article.
200 results