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An increased copy number of glycine decarboxylase (GLDC) associated with psychosis reduces extracellular glycine and impairs NMDA receptor function.
Kambali M, Li Y, Unichenko P, Feria Pliego JA, Yadav R, Liu J, McGuinness P, Cobb JG, Wang M, Nagarajan R, Lyu J, Vongsouthi V, Jackson CJ, Engin E, Coyle JT, Shin J, Hodgson NW, Hensch TK, Talkowski ME, Homanics GE, Bolshakov VY, Henneberger C, Rudolph U. Kambali M, et al. Among authors: jackson cj. Mol Psychiatry. 2024 Aug 30. doi: 10.1038/s41380-024-02711-5. Online ahead of print. Mol Psychiatry. 2024. PMID: 39210012
Monitoring hippocampal glycine with the computationally designed optical sensor GlyFS.
Zhang WH, Herde MK, Mitchell JA, Whitfield JH, Wulff AB, Vongsouthi V, Sanchez-Romero I, Gulakova PE, Minge D, Breithausen B, Schoch S, Janovjak H, Jackson CJ, Henneberger C. Zhang WH, et al. Among authors: jackson cj. Nat Chem Biol. 2018 Sep;14(9):861-869. doi: 10.1038/s41589-018-0108-2. Epub 2018 Jul 30. Nat Chem Biol. 2018. PMID: 30061718
Local Efficacy of Glutamate Uptake Decreases with Synapse Size.
Herde MK, Bohmbach K, Domingos C, Vana N, Komorowska-Müller JA, Passlick S, Schwarz I, Jackson CJ, Dietrich D, Schwarz MK, Henneberger C. Herde MK, et al. Among authors: jackson cj. Cell Rep. 2020 Sep 22;32(12):108182. doi: 10.1016/j.celrep.2020.108182. Cell Rep. 2020. PMID: 32966786 Free article.
A Rationally and Computationally Designed Fluorescent Biosensor for d-Serine.
Vongsouthi V, Whitfield JH, Unichenko P, Mitchell JA, Breithausen B, Khersonsky O, Kremers L, Janovjak H, Monai H, Hirase H, Fleishman SJ, Henneberger C, Jackson CJ. Vongsouthi V, et al. Among authors: jackson cj. ACS Sens. 2021 Nov 26;6(11):4193-4205. doi: 10.1021/acssensors.1c01803. Epub 2021 Nov 16. ACS Sens. 2021. PMID: 34783546
Improving plastic degrading enzymes via directed evolution.
Joho Y, Vongsouthi V, Gomez C, Larsen JS, Ardevol A, Jackson CJ. Joho Y, et al. Among authors: jackson cj. Protein Eng Des Sel. 2024 Jan 29;37:gzae009. doi: 10.1093/protein/gzae009. Protein Eng Des Sel. 2024. PMID: 38713696 Free PMC article. Review.
390 results