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Establishment of a novel amyotrophic lateral sclerosis patient (TARDBP N345K/+)-derived brain microvascular endothelial cell model reveals defective Wnt/β-catenin signaling: investigating diffusion barrier dysfunction and immune cell interaction.
Matsuo K, Nagamatsu J, Nagata K, Umeda R, Shiota T, Morimoto S, Suzuki N, Aoki M, Okano H, Nakamori M, Nishihara H. Matsuo K, et al. Among authors: okano h. Front Cell Dev Biol. 2024 Aug 15;12:1357204. doi: 10.3389/fcell.2024.1357204. eCollection 2024. Front Cell Dev Biol. 2024. PMID: 39211392 Free PMC article.
Phase 1/2a clinical trial in ALS with ropinirole, a drug candidate identified by iPSC drug discovery.
Morimoto S, Takahashi S, Ito D, Daté Y, Okada K, Kato C, Nakamura S, Ozawa F, Chyi CM, Nishiyama A, Suzuki N, Fujimori K, Kondo T, Takao M, Hirai M, Kabe Y, Suematsu M, Jinzaki M, Aoki M, Fujiki Y, Sato Y, Suzuki N, Nakahara J; Pooled Resource Open-Access ALS Clinical Trials Consortium; Okano H. Morimoto S, et al. Among authors: okano h. Cell Stem Cell. 2023 Jun 1;30(6):766-780.e9. doi: 10.1016/j.stem.2023.04.017. Cell Stem Cell. 2023. PMID: 37267913 Free article. Clinical Trial.
Generation of a tyrosine hydroxylase-2A-Cre knockin non-human primate model by homology-directed-repair-biased CRISPR genome editing.
Yoshimatsu S, Okahara J, Yoshie J, Igarashi Y, Nakajima R, Sanosaka T, Qian E, Sato T, Kobayashi H, Morimoto S, Kishi N, Pillis DM, Malik P, Noce T, Okano H. Yoshimatsu S, et al. Among authors: okano h. Cell Rep Methods. 2023 Sep 25;3(9):100590. doi: 10.1016/j.crmeth.2023.100590. Epub 2023 Sep 14. Cell Rep Methods. 2023. PMID: 37714158 Free PMC article.
Generation of four induced pluripotent stem cell lines (KEIUi004-A, KEIUi005-A, KEIUi006-A, and KEIUi007-A) from patients with sensorineural hearing loss with mutation in EYA4 gene.
Saegusa C, Mutai H, Saeki T, Matsuzaki S, Mizukoshi A, Kitajiri SI, Matsunaga T, Hosoya M, Okano H, Fujioka M. Saegusa C, et al. Among authors: okano h. Stem Cell Res. 2024 Sep;79:103489. doi: 10.1016/j.scr.2024.103489. Epub 2024 Jul 8. Stem Cell Res. 2024. PMID: 39002249 Free article.
Accumulation of ether phospholipids in induced pluripotent stem cells and oligodendrocyte-lineage cells established from patients with Sjögren-Larsson syndrome.
Yamaguchi Y, Okuno H, Tokuoka S, Kita Y, Sanosaka T, Kohyama J, Kurosawa K, Sakai N, Miya F, Takahashi T, Kosaki K, Okano H. Yamaguchi Y, et al. Among authors: okano h. Congenit Anom (Kyoto). 2025 Jan-Dec;65(1):e12587. doi: 10.1111/cga.12587. Congenit Anom (Kyoto). 2025. PMID: 39617394 Free PMC article.
1,699 results