Macauley M - Search Results

1

Chemoenzymatic Synthesis of Sulfated N-Glycans Recognized by Siglecs and Other Glycan-Binding Proteins.

Huang K, Bashian EE, Zong G, Nycholat CM, McBride R, Gomozkova M, Wang S, Huang C, Chapla DG, Schmidt EN, Macauley M, Moremen KW, Paulson JC, Wang LX. Huang K, et al. Among authors: macauley m. JACS Au. 2024 Jul 26;4(8):2966-2978. doi: 10.1021/jacsau.4c00307. eCollection 2024 Aug 26. JACS Au. 2024. PMID: 39211606 Free PMC article.

2

Probing synergy between two catalytic strategies in the glycoside hydrolase O-GlcNAcase using multiple linear free energy relationships.

Greig IR, Macauley MS, Williams IH, Vocadlo DJ. Greig IR, et al. J Am Chem Soc. 2009 Sep 23;131(37):13415-22. doi: 10.1021/ja904506u. J Am Chem Soc. 2009. PMID: 19715310

3

Analysis of PUGNAc and NAG-thiazoline as transition state analogues for human O-GlcNAcase: mechanistic and structural insights into inhibitor selectivity and transition state poise.

Whitworth GE, Macauley MS, Stubbs KA, Dennis RJ, Taylor EJ, Davies GJ, Greig IR, Vocadlo DJ. Whitworth GE, et al. J Am Chem Soc. 2007 Jan 24;129(3):635-44. doi: 10.1021/ja065697o. J Am Chem Soc. 2007. PMID: 17227027

4

Elevation of global O-GlcNAc levels in 3T3-L1 adipocytes by selective inhibition of O-GlcNAcase does not induce insulin resistance.

Macauley MS, Bubb AK, Martinez-Fleites C, Davies GJ, Vocadlo DJ. Macauley MS, et al. J Biol Chem. 2008 Dec 12;283(50):34687-95. doi: 10.1074/jbc.M804525200. Epub 2008 Oct 8. J Biol Chem. 2008. PMID: 18842583 Free PMC article.

5

O-GlcNAcase catalyzes cleavage of thioglycosides without general acid catalysis.

Macauley MS, Stubbs KA, Vocadlo DJ. Macauley MS, et al. J Am Chem Soc. 2005 Dec 14;127(49):17202-3. doi: 10.1021/ja0567687. J Am Chem Soc. 2005. PMID: 16332065

6

Elevation of Global O-GlcNAc in rodents using a selective O-GlcNAcase inhibitor does not cause insulin resistance or perturb glucohomeostasis.

Macauley MS, Shan X, Yuzwa SA, Gloster TM, Vocadlo DJ. Macauley MS, et al. Chem Biol. 2010 Sep 24;17(9):949-58. doi: 10.1016/j.chembiol.2010.07.005. Chem Biol. 2010. PMID: 20851344 Free PMC article.

7

O-GlcNAcase uses substrate-assisted catalysis: kinetic analysis and development of highly selective mechanism-inspired inhibitors.

Macauley MS, Whitworth GE, Debowski AW, Chin D, Vocadlo DJ. Macauley MS, et al. J Biol Chem. 2005 Jul 8;280(27):25313-22. doi: 10.1074/jbc.M413819200. Epub 2005 Mar 28. J Biol Chem. 2005. PMID: 15795231 Free article.

8

Visualizing the reaction coordinate of an O-GlcNAc hydrolase.

He Y, Macauley MS, Stubbs KA, Vocadlo DJ, Davies GJ. He Y, et al. J Am Chem Soc. 2010 Feb 17;132(6):1807-9. doi: 10.1021/ja9086769. J Am Chem Soc. 2010. PMID: 20067256

9

Increasing O-GlcNAc slows neurodegeneration and stabilizes tau against aggregation.

Yuzwa SA, Shan X, Macauley MS, Clark T, Skorobogatko Y, Vosseller K, Vocadlo DJ. Yuzwa SA, et al. Nat Chem Biol. 2012 Feb 26;8(4):393-9. doi: 10.1038/nchembio.797. Nat Chem Biol. 2012. PMID: 22366723

10

Metabolism of vertebrate amino sugars with N-glycolyl groups: intracellular β-O-linked N-glycolylglucosamine (GlcNGc), UDP-GlcNGc, and the biochemical and structural rationale for the substrate tolerance of β-O-linked β-N-acetylglucosaminidase.

Macauley MS, Chan J, Zandberg WF, He Y, Whitworth GE, Stubbs KA, Yuzwa SA, Bennet AJ, Varki A, Davies GJ, Vocadlo DJ. Macauley MS, et al. J Biol Chem. 2012 Aug 17;287(34):28882-97. doi: 10.1074/jbc.M112.363721. Epub 2012 Jun 12. J Biol Chem. 2012. PMID: 22692202 Free PMC article.

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