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Page 1
Accelerating drug discovery and repurposing by combining transcriptional signature connectivity with docking.
Thorman AW, Reigle J, Chutipongtanate S, Yang J, Shamsaei B, Pilarczyk M, Fazel-Najafabadi M, Adamczak R, Kouril M, Bhatnagar S, Hummel S, Niu W, Morrow AL, Czyzyk-Krzeska MF, McCullumsmith R, Seibel W, Nassar N, Zheng Y, Hildeman DA, Medvedovic M, Herr AB, Meller J. Thorman AW, et al. Among authors: reigle j. Sci Adv. 2024 Aug 30;10(35):eadj3010. doi: 10.1126/sciadv.adj3010. Epub 2024 Aug 30. Sci Adv. 2024. PMID: 39213358 Free PMC article.
Signature-based approaches for informed drug repurposing: targeting CNS disorders.
Shukla R, Henkel ND, Alganem K, Hamoud AR, Reigle J, Alnafisah RS, Eby HM, Imami AS, Creeden JF, Miruzzi SA, Meller J, Mccullumsmith RE. Shukla R, et al. Among authors: reigle j. Neuropsychopharmacology. 2021 Jan;46(1):116-130. doi: 10.1038/s41386-020-0752-6. Epub 2020 Jun 30. Neuropsychopharmacology. 2021. PMID: 32604402 Free PMC article. Review.
Tobacco smoking induces metabolic reprogramming of renal cell carcinoma.
Reigle J, Secic D, Biesiada J, Wetzel C, Shamsaei B, Chu J, Zang Y, Zhang X, Talbot NJ, Bischoff ME, Zhang Y, Thakar CV, Gaitonde K, Sidana A, Bui H, Cunningham JT, Zhang Q, Schmidt LS, Linehan WM, Medvedovic M, Plas DR, Figueroa JAL, Meller J, Czyzyk-Krzeska MF. Reigle J, et al. J Clin Invest. 2021 Jan 4;131(1):e140522. doi: 10.1172/JCI140522. J Clin Invest. 2021. PMID: 32970633 Free PMC article.
Microtubule-associated protein MAP1LC3C regulates lysosomal exocytosis and induces zinc reprogramming in renal cancer cells.
Verma R, Aggarwal P, Bischoff ME, Reigle J, Secic D, Wetzel C, VandenHeuvel K, Biesiada J, Ehmer B, Landero Figueroa JA, Plas DR, Medvedovic M, Meller J, Czyzyk-Krzeska MF. Verma R, et al. Among authors: reigle j. J Biol Chem. 2023 May;299(5):104663. doi: 10.1016/j.jbc.2023.104663. Epub 2023 Mar 30. J Biol Chem. 2023. PMID: 37003503 Free PMC article.
Coordinated Targeting of S6K1/2 and AXL Disrupts Pyrimidine Biosynthesis in PTEN-Deficient Glioblastoma.
Behrmann CA, Ennis KN, Sarma P, Wetzel C, Clark NA, Von Handorf KM, Vallabhapurapu S, Andreani C, Reigle J, Scaglioni PP, Meller J, Czyzyk-Krzeska MF, Kendler A, Qi X, Sarkaria JN, Medvedovic M, Sengupta S, Dasgupta B, Plas DR. Behrmann CA, et al. Among authors: reigle j. Cancer Res Commun. 2024 Aug 1;4(8):2215-2227. doi: 10.1158/2767-9764.CRC-23-0631. Cancer Res Commun. 2024. PMID: 39087397 Free PMC article.
Combining Neurobehavioral Analysis and In Vivo Photoaffinity Labeling to Understand Protein Targets of Methamphetamine in Casper Zebrafish.
Tackie-Yarboi E, Wisner A, Horton A, Chau TQT, Reigle J, Funk AJ, McCullumsmith RE, Hall FS, Williams FE, Schiefer IT. Tackie-Yarboi E, et al. Among authors: reigle j. ACS Chem Neurosci. 2020 Sep 2;11(17):2761-2773. doi: 10.1021/acschemneuro.0c00416. Epub 2020 Aug 18. ACS Chem Neurosci. 2020. PMID: 32786314 Free PMC article.
41 results