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Treatment with lipoxin A4 improves influenza A infection outcome, induces macrophage reprogramming, anti-inflammatory and pro-resolutive responses.
Rago F, Melo EM, Miller LM, Duray AM, Batista Felix F, Vago JP, de Faria Gonçalves AP, Angelo ALPM, Cassali GD, de Gaetano M, Brennan E, Owen B, Guiry P, Godson C, Alcorn JF, Teixeira MM. Rago F, et al. Among authors: brennan e. Inflamm Res. 2024 Nov;73(11):1903-1918. doi: 10.1007/s00011-024-01939-9. Epub 2024 Aug 30. Inflamm Res. 2024. PMID: 39214890
Lipoxins attenuate renal fibrosis by inducing let-7c and suppressing TGFβR1.
Brennan EP, Nolan KA, Börgeson E, Gough OS, McEvoy CM, Docherty NG, Higgins DF, Murphy M, Sadlier DM, Ali-Shah ST, Guiry PJ, Savage DA, Maxwell AP, Martin F, Godson C; GENIE Consortium. Brennan EP, et al. J Am Soc Nephrol. 2013 Mar;24(4):627-37. doi: 10.1681/ASN.2012060550. Epub 2013 Mar 21. J Am Soc Nephrol. 2013. PMID: 23520204 Free PMC article.
The genetics of diabetic nephropathy.
Brennan E, McEvoy C, Sadlier D, Godson C, Martin F. Brennan E, et al. Genes (Basel). 2013 Nov 5;4(4):596-619. doi: 10.3390/genes4040596. Genes (Basel). 2013. PMID: 24705265 Free PMC article.
Lipoxins Protect Against Inflammation in Diabetes-Associated Atherosclerosis.
Brennan EP, Mohan M, McClelland A, de Gaetano M, Tikellis C, Marai M, Crean D, Dai A, Beuscart O, Derouiche S, Gray SP, Pickering R, Tan SM, Godson-Treacy M, Sheehan S, Dowdall JF, Barry M, Belton O, Ali-Shah ST, Guiry PJ, Jandeleit-Dahm K, Cooper ME, Godson C, Kantharidis P. Brennan EP, et al. Diabetes. 2018 Dec;67(12):2657-2667. doi: 10.2337/db17-1317. Epub 2018 Sep 13. Diabetes. 2018. PMID: 30213823
Asymmetric synthesis and biological evaluation of imidazole- and oxazole-containing synthetic lipoxin A4 mimetics (sLXms).
de Gaetano M, Butler E, Gahan K, Zanetti A, Marai M, Chen J, Cacace A, Hams E, Maingot C, McLoughlin A, Brennan E, Leroy X, Loscher CE, Fallon P, Perretti M, Godson C, Guiry PJ. de Gaetano M, et al. Among authors: brennan e. Eur J Med Chem. 2019 Jan 15;162:80-108. doi: 10.1016/j.ejmech.2018.10.049. Epub 2018 Oct 23. Eur J Med Chem. 2019. PMID: 30419493
459 results