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Page 1
Autoantigen-specific CD4+ T cells acquire an exhausted phenotype and persist in human antigen-specific autoimmune diseases.
Saggau C, Bacher P, Esser D, Rasa M, Meise S, Mohr N, Kohlstedt N, Hutloff A, Schacht SS, Dargvainiene J, Martini GR, Stürner KH, Schröder I, Markewitz R, Hartl J, Hastermann M, Duchow A, Schindler P, Becker M, Bautista C, Gottfreund J, Walter J, Polansky JK, Yang M, Naghavian R, Wendorff M, Schuster EM, Dahl A, Petzold A, Reinhardt S, Franke A, Wieczorek M, Henschel L, Berger D, Heine G, Holtsche M, Häußler V, Peters C, Schmidt E, Fillatreau S, Busch DH, Wandinger KP, Schober K, Martin R, Paul F, Leypoldt F, Scheffold A. Saggau C, et al. Among authors: polansky jk. Immunity. 2024 Oct 8;57(10):2416-2432.e8. doi: 10.1016/j.immuni.2024.08.005. Epub 2024 Sep 2. Immunity. 2024. PMID: 39226901 Free article.
Single-cell profiling reveals age-associated immunity in atherosclerosis.
Smit V, de Mol J, Schaftenaar FH, Depuydt MAC, Postel RJ, Smeets D, Verheijen FWM, Bogers L, van Duijn J, Verwilligen RAF, Grievink HW, Bernabé Kleijn MNA, van Ingen E, de Jong MJM, Goncalves L, Peeters JAHM, Smeets HJ, Wezel A, Polansky JK, de Winther MPJ, Binder CJ, Tsiantoulas D, Bot I, Kuiper J, Foks AC. Smit V, et al. Among authors: polansky jk. Cardiovasc Res. 2023 Nov 25;119(15):2508-2521. doi: 10.1093/cvr/cvad099. Cardiovasc Res. 2023. PMID: 37390467 Free PMC article.
The life-saving benefit of dexamethasone in severe COVID-19 is linked to a reversal of monocyte dysregulation.
Knoll R, Helbig ET, Dahm K, Bolaji O, Hamm F, Dietrich O, van Uelft M, Müller S, Bonaguro L, Schulte-Schrepping J, Petrov L, Krämer B, Kraut M, Stubbemann P, Thibeault C, Brumhard S, Theis H, Hack G, De Domenico E, Nattermann J, Becker M, Beyer MD, Hillus D, Georg P, Loers C, Tiedemann J, Tober-Lau P, Lippert L, Millet Pascual-Leone B, Tacke F, Rohde G, Suttorp N, Witzenrath M; CAPNETZ Study Group; Pa-COVID-19 Study Group; Saliba AE, Ulas T, Polansky JK, Sawitzki B, Sander LE, Schultze JL, Aschenbrenner AC, Kurth F. Knoll R, et al. Among authors: polansky jk. Cell. 2024 Aug 8;187(16):4318-4335.e20. doi: 10.1016/j.cell.2024.06.014. Epub 2024 Jul 3. Cell. 2024. PMID: 38964327 Free article.
Effector memory-type regulatory T cells display phenotypic and functional instability.
Wendering DJ, Amini L, Schlickeiser S, Farrera-Sal M, Schulenberg S, Peter L, Mai M, Vollmer T, Du W, Stein M, Hamm F, Malard A, Castro C, Yang M, Ranka R, Rückert T, Durek P, Heinrich F, Gasparoni G, Salhab A, Walter J, Wagner DL, Mashreghi MF, Landwehr-Kenzel S, Polansky JK, Reinke P, Volk HD, Schmueck-Henneresse M. Wendering DJ, et al. Among authors: polansky jk. Sci Adv. 2024 Sep 6;10(36):eadn3470. doi: 10.1126/sciadv.adn3470. Epub 2024 Sep 4. Sci Adv. 2024. PMID: 39231218 Free PMC article.
The enhancer landscape predetermines the skeletal regeneration capacity of stromal cells.
Hochmann S, Ou K, Poupardin R, Mittermeir M, Textor M, Ali S, Wolf M, Ellinghaus A, Jacobi D, Elmiger JAJ, Donsante S, Riminucci M, Schäfer R, Kornak U, Klein O, Schallmoser K, Schmidt-Bleek K, Duda GN, Polansky JK, Geissler S, Strunk D. Hochmann S, et al. Among authors: polansky jk. Sci Transl Med. 2023 Mar 22;15(688):eabm7477. doi: 10.1126/scitranslmed.abm7477. Epub 2023 Mar 22. Sci Transl Med. 2023. PMID: 36947595
Strong Expansion of Human Regulatory T Cells for Adoptive Cell Therapy Results in Epigenetic Changes Which May Impact Their Survival and Function.
Ou K, Hamo D, Schulze A, Roemhild A, Kaiser D, Gasparoni G, Salhab A, Zarrinrad G, Amini L, Schlickeiser S, Streitz M, Walter J, Volk HD, Schmueck-Henneresse M, Reinke P, Polansky JK. Ou K, et al. Among authors: polansky jk. Front Cell Dev Biol. 2021 Nov 18;9:751590. doi: 10.3389/fcell.2021.751590. eCollection 2021. Front Cell Dev Biol. 2021. PMID: 34869339 Free PMC article.
Targeted De-Methylation of the FOXP3-TSDR Is Sufficient to Induce Physiological FOXP3 Expression but Not a Functional Treg Phenotype.
Kressler C, Gasparoni G, Nordström K, Hamo D, Salhab A, Dimitropoulos C, Tierling S, Reinke P, Volk HD, Walter J, Hamann A, Polansky JK. Kressler C, et al. Among authors: polansky jk. Front Immunol. 2021 Jan 7;11:609891. doi: 10.3389/fimmu.2020.609891. eCollection 2020. Front Immunol. 2021. PMID: 33488615 Free PMC article.
Killer-like receptors and GPR56 progressive expression defines cytokine production of human CD4+ memory T cells.
Truong KL, Schlickeiser S, Vogt K, Boës D, Stanko K, Appelt C, Streitz M, Grütz G, Stobutzki N, Meisel C, Iwert C, Tomiuk S, Polansky JK, Pascher A, Babel N, Stervbo U, Sauer I, Gerlach U, Sawitzki B. Truong KL, et al. Among authors: polansky jk. Nat Commun. 2019 May 22;10(1):2263. doi: 10.1038/s41467-019-10018-1. Nat Commun. 2019. PMID: 31118448 Free PMC article.
A comprehensive analysis of 195 DNA methylomes reveals shared and cell-specific features of partially methylated domains.
Salhab A, Nordström K, Gasparoni G, Kattler K, Ebert P, Ramirez F, Arrigoni L, Müller F, Polansky JK, Cadenas C, G Hengstler J, Lengauer T, Manke T; DEEP Consortium; Walter J. Salhab A, et al. Among authors: polansky jk. Genome Biol. 2018 Sep 28;19(1):150. doi: 10.1186/s13059-018-1510-5. Genome Biol. 2018. PMID: 30266094 Free PMC article.
CD137+CD154- Expression As a Regulatory T Cell (Treg)-Specific Activation Signature for Identification and Sorting of Stable Human Tregs from In Vitro Expansion Cultures.
Nowak A, Lock D, Bacher P, Hohnstein T, Vogt K, Gottfreund J, Giehr P, Polansky JK, Sawitzki B, Kaiser A, Walter J, Scheffold A. Nowak A, et al. Among authors: polansky jk. Front Immunol. 2018 Feb 7;9:199. doi: 10.3389/fimmu.2018.00199. eCollection 2018. Front Immunol. 2018. PMID: 29467769 Free PMC article.
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