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Optimization of PROTAC Ternary Complex Using DNA Encoded Library Approach.
Chen Q, Liu C, Wang W, Meng X, Cheng X, Li X, Cai L, Luo L, He X, Qu H, Luo J, Wei H, Gao S, Liu G, Wan J, Israel DI, Li J, Dou D. Chen Q, et al. Among authors: dou d. ACS Chem Biol. 2023 Jan 20;18(1):25-33. doi: 10.1021/acschembio.2c00797. Epub 2023 Jan 6. ACS Chem Biol. 2023. PMID: 36606710 Free PMC article.
Characterization of Specific N-α-Acetyltransferase 50 (Naa50) Inhibitors Identified Using a DNA Encoded Library.
Kung PP, Bingham P, Burke BJ, Chen Q, Cheng X, Deng YL, Dou D, Feng J, Gallego GM, Gehring MR, Grant SK, Greasley S, Harris AR, Maegley KA, Meier J, Meng X, Montano JL, Morgan BA, Naughton BS, Palde PB, Paul TA, Richardson P, Sakata S, Shaginian A, Sonnenburg WK, Subramanyam C, Timofeevski S, Wan J, Yan W, Stewart AE. Kung PP, et al. Among authors: dou d. ACS Med Chem Lett. 2020 Apr 10;11(6):1175-1184. doi: 10.1021/acsmedchemlett.0c00029. eCollection 2020 Jun 11. ACS Med Chem Lett. 2020. PMID: 32550998 Free PMC article.
The discovery of novel and potent indazole NLRP3 inhibitors enabled by DNA-encoded library screening.
Hartman G, Humphries P, Hughes R, Ho A, Montgomery R, Deshpande A, Mahanta M, Tronnes S, Cowdin S, He X, Liu F, Zhang L, Liu C, Dou D, Li J, Spasic A, Coll R, Marleaux M, Hochheiser IV, Geyer M, Rubin P, Fortney K, Wilhelmsen K. Hartman G, et al. Among authors: dou d. Bioorg Med Chem Lett. 2024 Apr 1;102:129675. doi: 10.1016/j.bmcl.2024.129675. Epub 2024 Feb 28. Bioorg Med Chem Lett. 2024. PMID: 38417632
Structural and Functional Insights into PpgL, a Metal-Independent β-Propeller Gluconolactonase That Contributes to Pseudomonas aeruginosa Virulence.
Song YJ, Wang KL, Shen YL, Gao J, Li T, Zhu YB, Li CC, He LH, Zhou QX, Zhao NL, Zhao C, Yang J, Huang Q, Mu XY, Li H, Dou DF, Liu C, He JH, Sun B, Bao R. Song YJ, et al. Infect Immun. 2019 Mar 25;87(4):e00847-18. doi: 10.1128/IAI.00847-18. Print 2019 Apr. Infect Immun. 2019. PMID: 30642898 Free PMC article.
Cyclosulfamide-based derivatives as inhibitors of noroviruses.
Dou D, Mandadapu SR, Alliston KR, Kim Y, Chang KO, Groutas WC. Dou D, et al. Eur J Med Chem. 2012 Jan;47(1):59-64. doi: 10.1016/j.ejmech.2011.10.019. Epub 2011 Oct 20. Eur J Med Chem. 2012. PMID: 22063754 Free PMC article.
Potent norovirus inhibitors based on the acyclic sulfamide scaffold.
Dou D, Tiew KC, Mandadapu SR, Gunnam MR, Alliston KR, Kim Y, Chang KO, Groutas WC. Dou D, et al. Bioorg Med Chem. 2012 Mar 15;20(6):2111-8. doi: 10.1016/j.bmc.2012.01.030. Epub 2012 Feb 2. Bioorg Med Chem. 2012. PMID: 22356738 Free PMC article.
604 results