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Page 1
Discovery and Optimization of N-Heteroaryl Indazole LRRK2 Inhibitors.
Logan KM, Kaplan W, Simov V, Zhou H, Li D, Torres L, Morriello GJ, Acton JJ, Pio B, Chen YH, Keylor MH, Johnson R, Kattar SD, Chau R, Yan X, Ardolino M, Zarate C, Otte KM, Palte RL, Xiong T, McMinn SE, Lin S, Neelamkavil SF, Liu P, Su J, Hegde LG, Woodhouse JD, Moy LY, Ciaccio PJ, Piesvaux J, Zebisch M, Henry C, Barker J, Wood HB, Kennedy ME, DiMauro EF, Fell MJ, Fuller PH. Logan KM, et al. Among authors: torres l. J Med Chem. 2024 Sep 26;67(18):16807-16819. doi: 10.1021/acs.jmedchem.4c01627. Epub 2024 Sep 4. J Med Chem. 2024. PMID: 39231262
The Discovery of 3-((4-Chloro-3-methoxyphenyl)amino)-1-((3R,4S)-4-cyanotetrahydro-2H-pyran-3-yl)-1H-pyrazole-4-carboxamide, a Highly Ligand Efficient and Efficacious Janus Kinase 1 Selective Inhibitor with Favorable Pharmacokinetic Properties.
Siu T, Brubaker J, Fuller P, Torres L, Zeng H, Close J, Mampreian DM, Shi F, Liu D, Fradera X, Johnson K, Bays N, Kadic E, He F, Goldenblatt P, Shaffer L, Patel SB, Lesburg CA, Alpert C, Dorosh L, Deshmukh SV, Yu H, Klappenbach J, Elwood F, Dinsmore CJ, Fernandez R, Moy L, Young JR. Siu T, et al. Among authors: torres l. J Med Chem. 2017 Dec 14;60(23):9676-9690. doi: 10.1021/acs.jmedchem.7b01135. Epub 2017 Dec 4. J Med Chem. 2017. PMID: 29156136
Identification of quinazoline based inhibitors of IRAK4 for the treatment of inflammation.
Smith GF, Altman MD, Andresen B, Baker J, Brubaker JD, Chen H, Chen Y, Childers M, Donofrio A, Ferguson H, Fischer C, Fischmann TO, Gibeau C, Hicks A, Jin S, Kattar S, Kleinschek MA, Leccese E, Lesburg C, Li C, Lim J, Liu D, Maclean JKF, Mansoor F, Moy LY, Mulrooney EF, Necheva AS, Presland J, Rakhilina L, Yang R, Torres L, Zhang-Hoover J, Northrup A. Smith GF, et al. Among authors: torres l. Bioorg Med Chem Lett. 2017 Jun 15;27(12):2721-2726. doi: 10.1016/j.bmcl.2017.04.050. Epub 2017 Apr 18. Bioorg Med Chem Lett. 2017. PMID: 28501511
Genome Sequence of Three Siphoviruses in the EE, GA and EA5 Actinobacteriophage Clusters: Biscayne, Bush and GreenIvy.
Purroy XS, Sierra BR, Becerra Reymundo L, Serradet VM, Camacho AM, Briceno NA, Artiles K, Lad P, Phan N, Rodriguez Leiva A, Appolon JN, Mikhail A, Ruiz AM, Rodriguez C, Vega D, Moyano G, Intrator G, Yasinski K, Mclean K, Gonzalez Giliberti N, Ramirez Ramirez E, Adolpho de Melo V, Alsina AS, Andino MY, Becker BA, Castellanos H, Castillo NA, Fernandez BS, Estinvil JR, Gonzalez AA, Hernandez EM, Ho A, Islam SF, Liubenco A, Mejia L, Meesala SN, Morales-Ramirez W, Morlote N, Ramos-Homs K, Rodriguez JA, Torres LM, Waikel P, Mayoral J. Purroy XS, et al. Among authors: torres lm. MicroPubl Biol. 2025 Jan 6;2025:10.17912/micropub.biology.001397. doi: 10.17912/micropub.biology.001397. eCollection 2025. MicroPubl Biol. 2025. PMID: 39839715 Free PMC article.
Optimizing automated photo identification for population assessments.
Patton PT, Pacifici K, Baird RW, Oleson EM, Allen JB, Ashe E, Athayde A, Basran CJ, Cabrera E, Calambokidis J, Cardoso J, Carroll EL, Cesario A, Cheney BJ, Cheeseman T, Corsi E, Currie JJ, Durban JW, Falcone EA, Fearnbach H, Flynn K, Franklin T, Franklin W, Vernazzani BG, Genova T, Hill M, Johnston DR, Keene EL, Lacey C, Mahaffy SD, McGuire TL, McPherson L, Meyer C, Michaud R, Miliou A, Olson GL, Orbach DN, Pearson HC, Rasmussen MH, Rayment WJ, Rinaldi C, Rinaldi R, Siciliano S, Stack SH, Tintore B, Torres LG, Towers JR, Moore RBT, Weir CR, Wellard R, Wells RS, Yano KM, Zaeschmar JR, Bejder L. Patton PT, et al. Among authors: torres lg. Conserv Biol. 2025 Jan 14:e14436. doi: 10.1111/cobi.14436. Online ahead of print. Conserv Biol. 2025. PMID: 39807876
Hypomethylating agents for patients with VEXAS without myelodysplastic syndrome: Clinical outcome and longitudinal follow-up of vacuolization and UBA1 clonal dynamics.
Álamo JR, Torres LM, Castaño-Díez S, Mensa-Vilaró A, Mónica López-Guerra M, Zugasti I, Díaz J, Jiménez-Vicente C, Plaza S, Fabregat V, de Landazuri IO, Yagüe J, Espinosa G, Sanmartí R, Rozman M, Guijarro F, Cortes A, Triguero A, Cardús A, Cuartas A, Cornejo M, Esteve J, Aróstegui JI, Díaz-Beyá M. Álamo JR, et al. Among authors: torres lm. Br J Haematol. 2025 Jan 13. doi: 10.1111/bjh.19953. Online ahead of print. Br J Haematol. 2025. PMID: 39806534
Comprehensive molecular epidemiology of influenza viruses in Brazil: insights from a nationwide analysis.
Brcko IC, de Souza VC, Ribeiro G, Lima ARJ, Martins AJ, Barros CRDS, de Carvalho E, Pereira JS, de Lima LPO, Viala VL, Kashima S, de La Roque DGL, Santos EV, Rodrigues ES, Nunes JA, Torres LS, Caldeira LAV, Palmieri M, Medina CG, de Arruda RA, Lopes RB, Sobrinho GR, Jorge DMM, Arruda E, Mendes ECBDS, Santos HO, de Mello ALES, Pereira FM, Gómez MKA, Nardy VB, Henrique B, Vieira LL, Roll MM, de Oliveira EC, Almeida JDPC, da Silva SF, Borges GAL, Furtado KCL, da Costa PMSSB, Chagas SMDS, Kallás EG, Larh D, Giovanetti M, Nanev Slavov S, Coccuzzo Sampaio S, Elias MC. Brcko IC, et al. Among authors: torres ls. Virus Evol. 2024 Nov 23;11(1):veae102. doi: 10.1093/ve/veae102. eCollection 2025. Virus Evol. 2024. PMID: 39802823 Free PMC article.
1,600 results