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Page 1
The scaffolding function of LSD1 controls DNA methylation in mouse ESCs.
Malla S, Kumari K, García-Prieto CA, Caroli J, Nordin A, Phan TTT, Bhattarai DP, Martinez-Gamero C, Dorafshan E, Stransky S, Álvarez-Errico D, Saiki PA, Lai W, Lyu C, Lizana L, Gilthorpe JD, Wang H, Sidoli S, Mateus A, Lee DF, Cantù C, Esteller M, Mattevi A, Roman AC, Aguilo F. Malla S, et al. Among authors: mattevi a. Nat Commun. 2024 Sep 5;15(1):7758. doi: 10.1038/s41467-024-51966-7. Nat Commun. 2024. PMID: 39237615 Free PMC article.
Uncoupling histone modification crosstalk by engineering lysine demethylase LSD1.
Lee K, Barone M, Waterbury AL, Jiang H, Nam E, DuBois-Coyne SE, Whedon SD, Wang ZA, Caroli J, Neal K, Ibeabuchi B, Dhoondia Z, Kuroda MI, Liau BB, Beck S, Mattevi A, Cole PA. Lee K, et al. Among authors: mattevi a. Nat Chem Biol. 2024 Jul 4:10.1038/s41589-024-01671-9. doi: 10.1038/s41589-024-01671-9. Online ahead of print. Nat Chem Biol. 2024. PMID: 38965385
Fine-tuned KDM1A alternative splicing regulates human cardiomyogenesis through an enzymatic-independent mechanism.
Astro V, Ramirez-Calderon G, Pennucci R, Caroli J, Saera-Vila A, Cardona-Londoño K, Forastieri C, Fiacco E, Maksoud F, Alowaysi M, Sogne E, Falqui A, Gonzàlez F, Montserrat N, Battaglioli E, Mattevi A, Adamo A. Astro V, et al. Among authors: mattevi a. iScience. 2022 Jun 23;25(7):104665. doi: 10.1016/j.isci.2022.104665. eCollection 2022 Jul 15. iScience. 2022. PMID: 35856020 Free PMC article.
Heterocycle-containing tranylcypromine derivatives endowed with high anti-LSD1 activity.
Fioravanti R, Rodriguez V, Caroli J, Chianese U, Benedetti R, Di Bello E, Noce B, Zwergel C, Corinti D, Viña D, Altucci L, Mattevi A, Valente S, Mai A. Fioravanti R, et al. Among authors: mattevi a. J Enzyme Inhib Med Chem. 2022 Dec;37(1):973-985. doi: 10.1080/14756366.2022.2052869. J Enzyme Inhib Med Chem. 2022. PMID: 35317680 Free PMC article.
Targeting the CoREST complex with dual histone deacetylase and demethylase inhibitors.
Kalin JH, Wu M, Gomez AV, Song Y, Das J, Hayward D, Adejola N, Wu M, Panova I, Chung HJ, Kim E, Roberts HJ, Roberts JM, Prusevich P, Jeliazkov JR, Roy Burman SS, Fairall L, Milano C, Eroglu A, Proby CM, Dinkova-Kostova AT, Hancock WW, Gray JJ, Bradner JE, Valente S, Mai A, Anders NM, Rudek MA, Hu Y, Ryu B, Schwabe JWR, Mattevi A, Alani RM, Cole PA. Kalin JH, et al. Among authors: mattevi a. Nat Commun. 2018 Jan 4;9(1):53. doi: 10.1038/s41467-017-02242-4. Nat Commun. 2018. PMID: 29302039 Free PMC article.
Protein recognition by short peptide reversible inhibitors of the chromatin-modifying LSD1/CoREST lysine demethylase.
Tortorici M, Borrello MT, Tardugno M, Chiarelli LR, Pilotto S, Ciossani G, Vellore NA, Bailey SG, Cowan J, O'Connell M, Crabb SJ, Packham G, Mai A, Baron R, Ganesan A, Mattevi A. Tortorici M, et al. Among authors: mattevi a. ACS Chem Biol. 2013 Aug 16;8(8):1677-82. doi: 10.1021/cb4001926. Epub 2013 Jun 11. ACS Chem Biol. 2013. PMID: 23721412
Targeting the scaffolding role of LSD1 (KDM1A) poises acute myeloid leukemia cells for retinoic acid-induced differentiation.
Ravasio R, Ceccacci E, Nicosia L, Hosseini A, Rossi PL, Barozzi I, Fornasari L, Zuffo RD, Valente S, Fioravanti R, Mercurio C, Varasi M, Mattevi A, Mai A, Pavesi G, Bonaldi T, Minucci S. Ravasio R, et al. Among authors: mattevi a. Sci Adv. 2020 Apr 8;6(15):eaax2746. doi: 10.1126/sciadv.aax2746. eCollection 2020 Apr. Sci Adv. 2020. PMID: 32284990 Free PMC article.
241 results