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Page 1
Impact of SARS-CoV-2 Resistance to Antiviral Monoclonal Antibody Therapy on Neutralizing Antibody Response.
Paul MK, Choudhary MC, Heaps AL, Deo R, Moisi D, Gordon KC, Mellors JW, Moser C, Klekotka P, Landay A, Currier JS, Eron JJ, Chew KW, Smith DM, Sieg SF, Parikh UM, Li JZ; ACTIV-2/A5401 Study Team. Paul MK, et al. Among authors: choudhary mc. Pathog Immun. 2024 Aug 21;9(2):79-93. doi: 10.20411/pai.v9i2.718. eCollection 2024. Pathog Immun. 2024. PMID: 39247686 Free PMC article.
Emergence of SARS-CoV-2 escape mutations during Bamlanivimab therapy in a phase II randomized clinical trial.
Choudhary MC, Chew KW, Deo R, Flynn JP, Regan J, Crain CR, Moser C, Hughes MD, Ritz J, Ribeiro RM, Ke R, Dragavon JA, Javan AC, Nirula A, Klekotka P, Greninger AL, Fletcher CV, Daar ES, Wohl DA, Eron JJ, Currier JS, Parikh UM, Sieg SF, Perelson AS, Coombs RW, Smith DM, Li JZ; ACTIV-2/A5401 Study Team. Choudhary MC, et al. Nat Microbiol. 2022 Nov;7(11):1906-1917. doi: 10.1038/s41564-022-01254-1. Epub 2022 Oct 26. Nat Microbiol. 2022. PMID: 36289399 Free PMC article. Clinical Trial.
Publisher Correction: Antiviral and clinical activity of bamlanivimab in a randomized trial of non-hospitalized adults with COVID-19.
Chew KW, Moser C, Daar ES, Wohl DA, Li JZ, Coombs RW, Ritz J, Giganti M, Javan AC, Li Y, Choudhary MC, Deo R, Malvestutto C, Klekotka P, Price K, Nirula A, Fischer W, Bala V, Ribeiro RM, Perelson AS, Fletcher CV, Eron JJ, Currier JS; ACTIV-2/A5401 Study Team; Hughes MD, Smith DM. Chew KW, et al. Among authors: choudhary mc. Nat Commun. 2023 Jan 19;14(1):333. doi: 10.1038/s41467-023-35835-3. Nat Commun. 2023. PMID: 36658128 Free PMC article. No abstract available.
Cell culture systems for isolation of SARS-CoV-2 clinical isolates and generation of recombinant virus.
Chen DY, Turcinovic J, Feng S, Kenney DJ, Chin CV, Choudhary MC, Conway HL, Semaan M, Close BJ, Tavares AH, Seitz S, Khan N, Kapell S, Crossland NA, Li JZ, Douam F, Baker SC, Connor JH, Saeed M. Chen DY, et al. Among authors: choudhary mc. iScience. 2023 May 19;26(5):106634. doi: 10.1016/j.isci.2023.106634. Epub 2023 Apr 10. iScience. 2023. PMID: 37095858 Free PMC article.
Variant-Specific Viral Kinetics in Acute COVID-19.
Ribeiro RM, Choudhary MC, Deo R, Giganti MJ, Moser C, Ritz J, Greninger AL, Regan J, Flynn JP, Wohl DA, Currier JS, Eron JJ, Hughes MD, Smith DM, Chew KW, Daar ES, Perelson AS, Li JZ; ACTIV-2/A5401 Study Team. Ribeiro RM, et al. Among authors: choudhary mc. J Infect Dis. 2023 Aug 31;228(Suppl 2):S136-S143. doi: 10.1093/infdis/jiad314. J Infect Dis. 2023. PMID: 37650233 Free PMC article. Clinical Trial.
Modeling the emergence of viral resistance for SARS-CoV-2 during treatment with an anti-spike monoclonal antibody.
Phan T, Zitzmann C, Chew KW, Smith DM, Daar ES, Wohl DA, Eron JJ, Currier JS, Hughes MD, Choudhary MC, Deo R, Li JZ, Ribeiro RM, Ke R, Perelson AS; ACTIV-2/A5401 Study Team. Phan T, et al. Among authors: choudhary mc. PLoS Pathog. 2024 Apr 18;20(4):e1011680. doi: 10.1371/journal.ppat.1011680. eCollection 2024 Apr. PLoS Pathog. 2024. PMID: 38635853 Free PMC article.
Comparison Study of the Bio-Plex and Meso Scale Multiplexed SARS-CoV-2 Serology Assays Reveals Evidence of Diminished Host Antibody Responses to SARS-CoV-2 after Monoclonal Antibody Treatment.
Parikh UM, Heaps AL, Moisi D, Gordon KC, Mellors JW, Choudhary MC, Deo R, Moser C, Klekotka P, Landay AL, Currier JS, Eron JJ, Chew KW, Smith DM, Li JZ, Sieg SF; Team ACTIV-2/A5401 Study. Parikh UM, et al. Among authors: choudhary mc. Pathog Immun. 2024 Aug 15;9(2):58-78. doi: 10.20411/pai.v9i2.715. eCollection 2024. Pathog Immun. 2024. PMID: 39165724 Free PMC article.
Cross-neutralization of distant coronaviruses correlates with Spike S2-specific antibodies from immunocompetent and immunocompromised vaccinated SARS-CoV-2-infected patients.
Patel SV, Leeman BM, Botros PJ, Folta J, Shahid D, Rocque AI, Joyal AS, Vecchio JA, Passell E, Tien D, Reynolds Z, Su K, Vyas TD, Vyas JM, Abar E, Barry M, Alexandrescu A, Wallace Z, DaCosta JM, Choudhary MC, Tamura T, Edelstein G, Li Y, Deo R, Sparks JA, Boucau J, Glover O, Barczak A, Lemieux J, Siedner MJ, Li JZ, Fofana IB. Patel SV, et al. Among authors: choudhary mc. Res Sq [Preprint]. 2024 Dec 5:rs.3.rs-5487774. doi: 10.21203/rs.3.rs-5487774/v1. Res Sq. 2024. PMID: 39678346 Free PMC article. Preprint.
Spike and nsp6 are key determinants of SARS-CoV-2 Omicron BA.1 attenuation.
Chen DY, Chin CV, Kenney D, Tavares AH, Khan N, Conway HL, Liu G, Choudhary MC, Gertje HP, O'Connell AK, Adams S, Kotton DN, Herrmann A, Ensser A, Connor JH, Bosmann M, Li JZ, Gack MU, Baker SC, Kirchdoerfer RN, Kataria Y, Crossland NA, Douam F, Saeed M. Chen DY, et al. Among authors: choudhary mc. Nature. 2023 Mar;615(7950):143-150. doi: 10.1038/s41586-023-05697-2. Epub 2023 Jan 11. Nature. 2023. PMID: 36630998
Modeling suggests SARS-CoV-2 rebound after nirmatrelvir-ritonavir treatment is driven by target cell preservation coupled with incomplete viral clearance.
Phan T, Ribeiro RM, Edelstein GE, Boucau J, Uddin R, Marino C, Liew MY, Barry M, Choudhary MC, Tien D, Su K, Reynolds Z, Li Y, Sagar S, Vyas TD, Kawano Y, Sparks JA, Hammond SP, Wallace Z, Vyas JM, Li JZ, Siedner MJ, Barczak AK, Lemieux JE, Perelson AS. Phan T, et al. Among authors: choudhary mc. bioRxiv [Preprint]. 2024 Sep 16:2024.09.13.613000. doi: 10.1101/2024.09.13.613000. bioRxiv. 2024. PMID: 39345409 Free PMC article. Preprint.
63 results