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The anti-cancer drug dabrafenib is not cardiotoxic and inhibits cardiac remodelling and fibrosis in a murine model of hypertension.
Meijles DN, Cull JJ, Cooper STE, Markou T, Hardyman MA, Fuller SJ, Alharbi HO, Haines ZHR, Alcantara-Alonso V, Glennon PE, Sheppard MN, Sugden PH, Clerk A. Meijles DN, et al. Among authors: alharbi ho. Clin Sci (Lond). 2021 Jul 30;135(14):1631-1647. doi: 10.1042/CS20210192. Clin Sci (Lond). 2021. PMID: 34296750 Free PMC article.
Cardiomyocyte BRAF and type 1 RAF inhibitors promote cardiomyocyte and cardiac hypertrophy in mice in vivo.
Clerk A, Meijles DN, Hardyman MA, Fuller SJ, Chothani SP, Cull JJ, Cooper STE, Alharbi HO, Vanezis K, Felkin LE, Markou T, Leonard SJ, Shaw SW, Rackham OJL, Cook SA, Glennon PE, Sheppard MN, Sembrat JC, Rojas M, McTiernan CF, Barton PJ, Sugden PH. Clerk A, et al. Among authors: alharbi ho. Biochem J. 2022 Feb 11;479(3):401-424. doi: 10.1042/BCJ20210615. Biochem J. 2022. PMID: 35147166 Free PMC article.
PKN2 deficiency leads both to prenatal 'congenital' cardiomyopathy and defective angiotensin II stress responses.
Marshall JJT, Cull JJ, Alharbi HO, Zaw Thin M, Cooper STE, Barrington C, Vanyai H, Snoeks T, Siow B, Suáarez-Bonnet A, Herbert E, Stuckey DJ, Cameron AJM, Prin F, Cook AC, Priestnall SL, Chotani S, Rackham OJL, Meijles DN, Mohun T, Clerk A, Parker PJ. Marshall JJT, et al. Among authors: alharbi ho. Biochem J. 2022 Jul 15;479(13):1467-1486. doi: 10.1042/BCJ20220281. Biochem J. 2022. PMID: 35730579 Free PMC article.
18 results