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Modeling Lewy body disease with SNCA triplication iPSC-derived cortical organoids and identifying therapeutic drugs.
Jin Y, Li F, Li Z, Ikezu TC, O'Leary J, Selvaraj M, Zhu Y, Martens YA, Koga S, Santhakumar H, Li Y, Lu W, You Y, Lolo K, DeTure M, Beasley AI, Davis MD, McLean PJ, Ross OA, Kanekiyo T, Ikezu T, Caulfield T, Carr J, Wszolek ZK, Bu G, Dickson DW, Zhao N. Jin Y, et al. Among authors: bu g. Sci Adv. 2024 Sep 13;10(37):eadk3700. doi: 10.1126/sciadv.adk3700. Epub 2024 Sep 11. Sci Adv. 2024. PMID: 39259788 Free PMC article.
A novel link between trafficking and Lewy body disorders.
Ross OA, Bu G. Ross OA, et al. Among authors: bu g. Lancet Neurol. 2018 Jul;17(7):571-573. doi: 10.1016/S1474-4422(18)30214-X. Epub 2018 Jun 7. Lancet Neurol. 2018. PMID: 29887160 No abstract available.
APOE4 exacerbates synapse loss and neurodegeneration in Alzheimer's disease patient iPSC-derived cerebral organoids.
Zhao J, Fu Y, Yamazaki Y, Ren Y, Davis MD, Liu CC, Lu W, Wang X, Chen K, Cherukuri Y, Jia L, Martens YA, Job L, Shue F, Nguyen TT, Younkin SG, Graff-Radford NR, Wszolek ZK, Brafman DA, Asmann YW, Ertekin-Taner N, Kanekiyo T, Bu G. Zhao J, et al. Among authors: bu g. Nat Commun. 2020 Nov 2;11(1):5540. doi: 10.1038/s41467-020-19264-0. Nat Commun. 2020. PMID: 33139712 Free PMC article.
Apolipoprotein E regulates lipid metabolism and α-synuclein pathology in human iPSC-derived cerebral organoids.
Zhao J, Lu W, Ren Y, Fu Y, Martens YA, Shue F, Davis MD, Wang X, Chen K, Li F, Liu CC, Graff-Radford NR, Wszolek ZK, Younkin SG, Brafman DA, Ertekin-Taner N, Asmann YW, Dickson DW, Xu Z, Pan M, Han X, Kanekiyo T, Bu G. Zhao J, et al. Among authors: bu g. Acta Neuropathol. 2021 Nov;142(5):807-825. doi: 10.1007/s00401-021-02361-9. Epub 2021 Aug 28. Acta Neuropathol. 2021. PMID: 34453582 Free PMC article.
APOE4 exacerbates α-synuclein seeding activity and contributes to neurotoxicity in Alzheimer's disease with Lewy body pathology.
Jin Y, Li F, Sonoustoun B, Kondru NC, Martens YA, Qiao W, Heckman MG, Ikezu TC, Li Z, Burgess JD, Amerna D, O'Leary J, DeTure MA, Zhao J, McLean PJ, Dickson DW, Ross OA, Bu G, Zhao N. Jin Y, et al. Among authors: bu g. Acta Neuropathol. 2022 Jun;143(6):641-662. doi: 10.1007/s00401-022-02421-8. Epub 2022 Apr 26. Acta Neuropathol. 2022. PMID: 35471463 Free PMC article.
Frontotemporal dementia-associated N279K tau mutant disrupts subcellular vesicle trafficking and induces cellular stress in iPSC-derived neural stem cells.
Wren MC, Zhao J, Liu CC, Murray ME, Atagi Y, Davis MD, Fu Y, Okano HJ, Ogaki K, Strongosky AJ, Tacik P, Rademakers R, Ross OA, Dickson DW, Wszolek ZK, Kanekiyo T, Bu G. Wren MC, et al. Among authors: bu g. Mol Neurodegener. 2015 Sep 15;10:46. doi: 10.1186/s13024-015-0042-7. Mol Neurodegener. 2015. PMID: 26373282 Free PMC article.
594 results