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Progress on the development of Class A GPCR-biased ligands.
Morales P, Scharf MM, Bermudez M, Egyed A, Franco R, Hansen OK, Jagerovic N, Jakubík J, Keserű GM, Kiss DJ, Kozielewicz P, Larsen O, Majellaro M, Mallo-Abreu A, Navarro G, Prieto-Díaz R, Rosenkilde MM, Sotelo E, Stark H, Werner T, Wingler LM. Morales P, et al. Among authors: werner t. Br J Pharmacol. 2024 Sep 11. doi: 10.1111/bph.17301. Online ahead of print. Br J Pharmacol. 2024. PMID: 39261899 Review.
Anti-inflammatory effects of new human histamine H3 receptor ligands with flavonoid structure on BV-2 neuroinflammation.
Honkisz-Orzechowska E, Popiołek-Barczyk K, Linart Z, Filipek-Gorzała J, Rudnicka A, Siwek A, Werner T, Stark H, Chwastek J, Starowicz K, Kieć-Kononowicz K, Łażewska D. Honkisz-Orzechowska E, et al. Among authors: werner t. Inflamm Res. 2023 Feb;72(2):181-194. doi: 10.1007/s00011-022-01658-z. Epub 2022 Nov 12. Inflamm Res. 2023. PMID: 36370200 Free PMC article.
Guanidines: Synthesis of Novel Histamine H3R Antagonists with Additional Breast Anticancer Activity and Cholinesterases Inhibitory Effect.
Staszewski M, Iwan M, Werner T, Bajda M, Godyń J, Latacz G, Korga-Plewko A, Kubik J, Szałaj N, Stark H, Malawska B, Więckowska A, Walczyński K. Staszewski M, et al. Among authors: werner t. Pharmaceuticals (Basel). 2023 Apr 30;16(5):675. doi: 10.3390/ph16050675. Pharmaceuticals (Basel). 2023. PMID: 37242458 Free PMC article.
Phenotype-Led Identification of IL-10 Upregulators in Human CD4+ T-cells and Elucidation of Their Pharmacology as Highly Selective CDK8/CDK19 Inhibitors.
Nicolle S, Barker M, Barrett J, Campbell M, Wojno-Picon J, Atkinson SJ, Aylott H, Kessedjian H, He Y, Messenger C, Roberts E, Spitzfaden C, Le J, Zinn N, Werner T, Dümpelfeld B, Bantscheff M, Somers DO, Reid H, Thang K, Gobbetti T, Lewis HD. Nicolle S, et al. Among authors: werner t. J Med Chem. 2025 Jan 8. doi: 10.1021/acs.jmedchem.4c02630. Online ahead of print. J Med Chem. 2025. PMID: 39780505
Near-Infrared Probes Designed with Hemicyanine Fluorophores Featuring Rhodamine and 1,8-Naphthalic Derivatives for Viscosity and HSA Detection in Live Cells.
Olowolagba AM, Aworinde OR, Dwivedi SK, Idowu MO, Arachchige DL, Wang C, Graham OR, Peters J, Rickauer G, Werner T, Ata A, Luck RL, Liu H. Olowolagba AM, et al. Among authors: werner t. ACS Appl Bio Mater. 2025 Jan 6. doi: 10.1021/acsabm.4c01721. Online ahead of print. ACS Appl Bio Mater. 2025. PMID: 39757836
878 results