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Factors Influencing the Central Nervous System (CNS) Distribution of the Ataxia Telangiectasia Mutated and Rad3-Related Inhibitor Elimusertib (BAY1895344): Implications for the Treatment of CNS Tumors.
Rathi S, Mladek AC, Oh JH, Dragojevic S, Burgenske DM, Zhang W, Talele S, Zhang W, Bakken KK, Carlson BL, Connors MA, He L, Hu Z, Sarkaria JN, Elmquist WF. Rathi S, et al. Among authors: hu z. J Pharmacol Exp Ther. 2024 Oct 18;391(2):346-360. doi: 10.1124/jpet.123.002002. J Pharmacol Exp Ther. 2024. PMID: 39284626
Preclinical modeling in glioblastoma patient-derived xenograft (GBM PDX) xenografts to guide clinical development of lisavanbulin-a novel tumor checkpoint controller targeting microtubules.
Burgenske DM, Talele S, Pokorny JL, Mladek AC, Bakken KK, Carlson BL, Schroeder MA, He L, Hu Z, Gampa G, Kosel ML, Decker PA, Kitange GJ, Schmitt-Hoffmann A, Bachmann F, Vaubel RA, Eckel-Passow JE, Giannini C, McSheehy P, Lane HA, Elmquist WF, Sarkaria JN. Burgenske DM, et al. Among authors: hu z. Neuro Oncol. 2022 Mar 12;24(3):384-395. doi: 10.1093/neuonc/noab162. Neuro Oncol. 2022. PMID: 34232318 Free PMC article.
RBBP4-p300 axis modulates expression of genes essential for cell survival and is a potential target for therapy in glioblastoma.
Mladek AC, Yan H, Tian S, Decker PA, Burgenske DM, Bakken K, Hu Z, He L, Connors MA, Carlson BL, Wilson J, Bommi-Reddy A, Conery A, Eckel-Passow JE, Sarkaria JN, Kitange GJ. Mladek AC, et al. Among authors: hu z. Neuro Oncol. 2022 Aug 1;24(8):1261-1272. doi: 10.1093/neuonc/noac051. Neuro Oncol. 2022. PMID: 35231103 Free PMC article.
Convection enhanced delivery of EGFR targeting antibody-drug conjugates Serclutamab talirine and Depatux-M in glioblastoma patient-derived xenografts.
Porath KA, Regan MS, Griffith JI, Jain S, Stopka SA, Burgenske DM, Bakken KK, Carlson BL, Decker PA, Vaubel RA, Dragojevic S, Mladek AC, Connors MA, Hu Z, He L, Kitange GJ, Gupta SK, Feldsien TM, Lefebvre DR, Agar NYR, Eckel-Passow JE, Reilly EB, Elmquist WF, Sarkaria JN. Porath KA, et al. Among authors: hu z. Neurooncol Adv. 2022 Aug 24;4(1):vdac130. doi: 10.1093/noajnl/vdac130. eCollection 2022 Jan-Dec. Neurooncol Adv. 2022. PMID: 36071925 Free PMC article.
Differential Distribution of the DNA-PKcs Inhibitor Peposertib Selectively Radiosensitizes Patient-derived Melanoma Brain Metastasis Xenografts.
Ji J, Dragojevic S, Callaghan CM, Smith EJ, Talele S, Zhang W, Connors MA, Mladek AC, Hu Z, Bakken KK, Sarkaria PP, Carlson BL, Burgenske DM, Decker PA, Rashid MA, Jang MH, Gupta SK, Eckel-Passow JE, Elmquist WF, Sarkaria JN. Ji J, et al. Among authors: hu z. Mol Cancer Ther. 2024 May 2;23(5):662-671. doi: 10.1158/1535-7163.MCT-23-0552. Mol Cancer Ther. 2024. PMID: 38224566 Free PMC article.
Bystander Effects, Pharmacokinetics, and Linker-Payload Stability of EGFR-Targeting Antibody-Drug Conjugates Losatuxizumab Vedotin and Depatux-M in Glioblastoma Models.
Jain S, Griffith JI, Porath KA, Rathi S, Le J, Pasa TI, Decker PA, Gupta SK, Hu Z, Carlson BL, Bakken K, Burgenske DM, Feldsien TM, Lefebvre DR, Vaubel RA, Eckel-Passow JE, Reilly EB, Elmquist WF, Sarkaria JN. Jain S, et al. Among authors: hu z. Clin Cancer Res. 2024 Aug 1;30(15):3287-3297. doi: 10.1158/1078-0432.CCR-24-0426. Clin Cancer Res. 2024. PMID: 38743766 Free PMC article.
DNA-PK inhibition shows differential radiosensitization in orthotopic GBM PDX models based on DDR pathway deficits.
Dragojevic S, Smith EJ, Regan MS, Stopka SA, Baquer G, Xue Z, Zhang W, Connors MA, Kloeber JA, Hu Z, Bakken KK, Ott LL, Carlson BL, Burgenske DM, Decker PA, Tian S, Gupta SK, Laverty DJ, Eckel-Passow JE, Elmquist WF, Agar NYR, Nagel ZD, Sarkaria JN, Callaghan CM. Dragojevic S, et al. Among authors: hu z. Mol Cancer Ther. 2024 Oct 23. doi: 10.1158/1535-7163.MCT-24-0003. Online ahead of print. Mol Cancer Ther. 2024. PMID: 39440433
Modeling the acute mucosal toxicity to fractionated radiotherapy combined with the ATM inhibitor WSD0628.
Garcia DA, Rathi S, Connors MA, Grams M, Vaubel RA, Bakken KK, Ott LL, Carlson BL, Hu Z, Decker PA, Eckel-Passow JE, Burgenske DM, Zhong W, Trzasko JD, Herman MG, Elmquist WF, Remmes NB, Sarkaria JN. Garcia DA, et al. Among authors: hu z. Mol Cancer Ther. 2024 Nov 19. doi: 10.1158/1535-7163.MCT-24-0664. Online ahead of print. Mol Cancer Ther. 2024. PMID: 39559836
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