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Development of miniature base editors using engineered IscB nickase.
Han D, Xiao Q, Wang Y, Zhang H, Dong X, Li G, Kong X, Wang S, Song J, Zhang W, Zhou J, Bi L, Yuan Y, Shi L, Zhong N, Yang H, Zhou Y. Han D, et al. Among authors: zhou y, zhou j. Nat Methods. 2023 Jul;20(7):1029-1036. doi: 10.1038/s41592-023-01898-9. Epub 2023 May 25. Nat Methods. 2023. PMID: 37231266
An engineered xCas12i with high activity, high specificity, and broad PAM range.
Zhang H, Kong X, Xue M, Hu J, Wang Z, Wei Y, Wang H, Zhou J, Zhang W, Xu M, Shen X, Yin F, Ai Z, Huang G, Xia J, Song X, Li H, Yuan Y, Li J, Zhong N, Zhang M, Zhou Y, Yang H. Zhang H, et al. Among authors: zhou y, zhou j. Protein Cell. 2023 Jun 28;14(7):538-543. doi: 10.1093/procel/pwac052. Protein Cell. 2023. PMID: 37378659 Free PMC article. No abstract available.
Engineered IscB-ωRNA system with expanded target range for base editing.
Xiao Q, Li G, Han D, Wang H, Yao M, Ma T, Zhou J, Zhang Y, Zhang X, He B, Yuan Y, Shi L, Li T, Yang H, Huang J, Zhang H. Xiao Q, et al. Among authors: zhou j. Nat Chem Biol. 2025 Jan;21(1):100-108. doi: 10.1038/s41589-024-01706-1. Epub 2024 Aug 15. Nat Chem Biol. 2025. PMID: 39147927
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