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PET imaging in rat brain shows opposite effects of acute and chronic alcohol exposure on phosphodiesterase-4B, an indirect biomarker of cAMP activity.
Tang S, Kim SW, Olsen-Dufour A, Pearson T, Freaney M, Singley E, Jenkins M, Burkard NJ, Wozniak A, Parcon P, Wu S, Morse CL, Jana S, Liow JS, Zoghbi SS, Vendruscolo JCM, Vendruscolo LF, Pike VW, Koob GF, Volkow ND, Innis RB. Tang S, et al. Among authors: freaney m. Neuropsychopharmacology. 2024 Dec;50(2):444-451. doi: 10.1038/s41386-024-01988-y. Epub 2024 Sep 16. Neuropsychopharmacology. 2024. PMID: 39285225 Free PMC article.
Investigation of [11C]carfentanil for mu opioid receptor quantification in the rat brain.
Kelleher AC, Pearson TD, Ramsey J, Zhao W, O'Conor KA, Bakhoda A, Stodden T, Guo M, Eisenberg SM, Shah SV, Freaney ML, Kim W, Kang Y, Tomasi D, Johnson C, Fang CA, Volkow ND, Kim SW. Kelleher AC, et al. Among authors: freaney ml. Sci Rep. 2024 Jul 15;14(1):16250. doi: 10.1038/s41598-024-66144-4. Sci Rep. 2024. PMID: 39009645 Free PMC article.
Lhs1 dependent ERAD is determined by transmembrane domain context.
Sukhoplyasova M, Keith AM, Perrault EM, Vorndran HE, Jordahl AS, Yates ME, Pastor A, Li Z, Freaney ML, Deshpande RA, Adams DB, Guerriero CJ, Shi S, Kleyman TR, Kashlan OB, Brodsky JL, Buck TM. Sukhoplyasova M, et al. Among authors: freaney ml. Biochem J. 2023 Sep 27;480(18):1459-1473. doi: 10.1042/BCJ20230075. Biochem J. 2023. PMID: 37702403 Free PMC article.