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PET imaging in rat brain shows opposite effects of acute and chronic alcohol exposure on phosphodiesterase-4B, an indirect biomarker of cAMP activity.
Tang S, Kim SW, Olsen-Dufour A, Pearson T, Freaney M, Singley E, Jenkins M, Burkard NJ, Wozniak A, Parcon P, Wu S, Morse CL, Jana S, Liow JS, Zoghbi SS, Vendruscolo JCM, Vendruscolo LF, Pike VW, Koob GF, Volkow ND, Innis RB. Tang S, et al. Among authors: jenkins m. Neuropsychopharmacology. 2024 Dec;50(2):444-451. doi: 10.1038/s41386-024-01988-y. Epub 2024 Sep 16. Neuropsychopharmacology. 2024. PMID: 39285225 Free PMC article.
First-in-Human Evaluation of 18F-PF-06445974, a PET Radioligand That Preferentially Labels Phosphodiesterase-4B.
Wakabayashi Y, Stenkrona P, Arakawa R, Yan X, Van Buskirk MG, Jenkins MD, Santamaria JAM, Maresca KP, Takano A, Liow JS, Chappie TA, Varrone A, Nag S, Zhang L, Hughes ZA, Schmidt CJ, Doran SD, Mannes A, Zanotti-Fregonara P, Ooms M, Morse CL, Zoghbi SS, Halldin C, Pike VW, Innis RB. Wakabayashi Y, et al. Among authors: jenkins md. J Nucl Med. 2022 Dec;63(12):1919-1924. doi: 10.2967/jnumed.122.263838. Epub 2022 Jun 30. J Nucl Med. 2022. PMID: 35772961 Free PMC article.
Discovery of a High-Affinity Fluoromethyl Analog of [11C]5-Cyano-N-(4-(4-methylpiperazin-1-yl)-2-(piperidin-1-yl)phenyl)furan-2-carboxamide ([11C]CPPC) and Their Comparison in Mouse and Monkey as Colony-Stimulating Factor 1 Receptor Positron Emission Tomography Radioligands.
Altomonte S, Yan X, Morse CL, Liow JS, Jenkins MD, Montero Santamaria JA, Zoghbi SS, Innis RB, Pike VW. Altomonte S, et al. ACS Pharmacol Transl Sci. 2023 Mar 10;6(4):614-632. doi: 10.1021/acsptsci.3c00003. eCollection 2023 Apr 14. ACS Pharmacol Transl Sci. 2023. PMID: 37082755 Free PMC article.
In vivo evaluation of a novel 18F-labeled PET radioligand for translocator protein 18 kDa (TSPO) in monkey brain.
Yan X, Siméon FG, Liow JS, Morse CL, Montero Santamaria JA, Jenkins M, Manly LS, Van Buskirk M, Zoghbi SS, Pike VW, Innis RB, Zanotti-Fregonara P. Yan X, et al. Among authors: jenkins m. Eur J Nucl Med Mol Imaging. 2023 Aug;50(10):2962-2970. doi: 10.1007/s00259-023-06270-9. Epub 2023 May 30. Eur J Nucl Med Mol Imaging. 2023. PMID: 37249618 Free PMC article.
[11C]PS13 Demonstrates Pharmacologically Selective and Substantial Binding to Cyclooxygenase-1 in the Human Brain.
Ghazanfari N, Liow JS, Kim MJ, Cureton R, Lee A, Knoer C, Jenkins M, Hong J, Santamaria JAM, Shetty HU, Galassi A, Wighton P, Nørgaard M, Greve DN, Zoghbi SS, Pike VW, Innis RB, Zanotti-Fregonara P. Ghazanfari N, et al. Among authors: jenkins m. J Nucl Med. 2024 Nov 14:jnumed.124.267928. doi: 10.2967/jnumed.124.267928. Online ahead of print. J Nucl Med. 2024. PMID: 39542698
[18F]SF51, a novel 18F-labeled PET radioligand for translocator protein 18kDa (TSPO) in brain, works well in monkeys but fails in humans.
Yan X, Siméon FG, Liow JS, Morse CL, Jana S, Montero Santamaria JA, Jenkins M, Zoghbi SS, Pike VW, Innis RB, Zanotti-Fregonara P. Yan X, et al. Among authors: jenkins m. J Cereb Blood Flow Metab. 2024 Dec 9:271678X241304924. doi: 10.1177/0271678X241304924. Online ahead of print. J Cereb Blood Flow Metab. 2024. PMID: 39654356 Free PMC article.
2,559 results