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Intrinsically disordered RNA-binding motifs cooperate to catalyze RNA folding and drive phase separation.
Niedner-Boblenz A, Monecke T, Hennig J, Klostermann M, Hofweber M, Davydova E, Gerber AP, Anosova I, Mayer W, Müller M, Heym RG, Janowski R, Paillart JC, Dormann D, Zarnack K, Sattler M, Niessing D. Niedner-Boblenz A, et al. Among authors: niessing d. Nucleic Acids Res. 2024 Dec 11;52(22):14205-14228. doi: 10.1093/nar/gkae1107. Nucleic Acids Res. 2024. PMID: 39558160 Free PMC article.
A naturally occurring 22-amino acid fragment of human hemoglobin A inhibits autophagy and HIV-1.
Freisem D, Rodriguez-Alfonso AA, Lawrenz J, Zhou Z, Monecke T, Preising N, Endres S, Wiese S, Ständker L, Kuan SL, Thal DR, Weil T, Niessing D, Barth H, Kirchhoff F, Harms M, Münch J, Sparrer KMJ. Freisem D, et al. Among authors: niessing d. Cell Mol Life Sci. 2024 Sep 17;81(1):409. doi: 10.1007/s00018-024-05447-1. Cell Mol Life Sci. 2024. PMID: 39289189 Free PMC article.
Inherited PURA Pathogenic Variant Associated With a Mild Neurodevelopmental Disorder.
Hildebrand MS, Braden RO, Lauretta ML, Kaspi A, Leventer RJ, Anderson M, Goel H, Bahlo M, Scheffer IE, Amor DJ, Janowski R, Niessing D, Morgan AT. Hildebrand MS, et al. Among authors: niessing d. Neurol Genet. 2024 Aug 6;10(5):e200181. doi: 10.1212/NXG.0000000000200181. eCollection 2024 Oct. Neurol Genet. 2024. PMID: 39131487 Free PMC article.
PURA syndrome-causing mutations impair PUR-domain integrity and affect P-body association.
Proske M, Janowski R, Bacher S, Kang HS, Monecke T, Koehler T, Hutten S, Tretter J, Crois A, Molitor L, Varela-Rial A, Fino R, Donati E, De Fabritiis G, Dormann D, Sattler M, Niessing D. Proske M, et al. Among authors: niessing d. Elife. 2024 Apr 24;13:RP93561. doi: 10.7554/eLife.93561. Elife. 2024. PMID: 38655849 Free PMC article.
Human TRMT2A methylates tRNA and contributes to translation fidelity.
Witzenberger M, Burczyk S, Settele D, Mayer W, Welp LM, Heiss M, Wagner M, Monecke T, Janowski R, Carell T, Urlaub H, Hauck SM, Voigt A, Niessing D. Witzenberger M, et al. Among authors: niessing d. Nucleic Acids Res. 2023 Sep 8;51(16):8691-8710. doi: 10.1093/nar/gkad565. Nucleic Acids Res. 2023. PMID: 37395448 Free PMC article.
Depletion of the RNA-binding protein PURA triggers changes in posttranscriptional gene regulation and loss of P-bodies.
Molitor L, Klostermann M, Bacher S, Merl-Pham J, Spranger N, Burczyk S, Ketteler C, Rusha E, Tews D, Pertek A, Proske M, Busch A, Reschke S, Feederle R, Hauck SM, Blum H, Drukker M, Fischer-Posovszky P, König J, Zarnack K, Niessing D. Molitor L, et al. Among authors: niessing d. Nucleic Acids Res. 2023 Feb 22;51(3):1297-1316. doi: 10.1093/nar/gkac1237. Nucleic Acids Res. 2023. PMID: 36651277 Free PMC article.
A novel monoclonal IgG1 antibody specific for Galactose-alpha-1,3-galactose questions alpha-Gal epitope expression by bacteria.
Kreft L, Schepers A, Hils M, Swiontek K, Flatley A, Janowski R, Mirzaei MK, Dittmar M, Chakrapani N, Desai MS, Eyerich S, Deng L, Niessing D, Fischer K, Feederle R, Blank S, Schmidt-Weber CB, Hilger C, Biedermann T, Ohnmacht C. Kreft L, et al. Among authors: niessing d. Front Immunol. 2022 Aug 5;13:958952. doi: 10.3389/fimmu.2022.958952. eCollection 2022. Front Immunol. 2022. PMID: 35990627 Free PMC article.
Compound heterozygous variants in OTULIN are associated with fulminant atypical late-onset ORAS.
Zinngrebe J, Moepps B, Monecke T, Gierschik P, Schlichtig F, Barth TFE, Strauß G, Boldrin E, Posovszky C, Schulz A, Beringer O, Rieser E, Jacobsen EM, Lorenz MR, Schwarz K, Pannicke U, Walczak H, Niessing D, Schuetz C, Fischer-Posovszky P, Debatin KM. Zinngrebe J, et al. Among authors: niessing d. EMBO Mol Med. 2022 Mar 7;14(3):e14901. doi: 10.15252/emmm.202114901. Epub 2022 Feb 16. EMBO Mol Med. 2022. PMID: 35170849 Free PMC article.
71 results