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Page 1
Discovery of GNE-6893, a Potent, Selective, Orally Bioavailable Small Molecule Inhibitor of HPK1.
Tellis JC, Wei B, Siu M, An L, Chan GK, Chen Y, Du X, Gazzard L, Hu B, Kiefer J, Kakiuchi-Kiyota S, Lainchbury M, Linehan JL, Luo X, Malhotra S, Mendonca R, Pang J, Ran Y, Sethuraman V, Seward E, Sneeringer C, Su D, Wang W, Wu P, Moffat JG, Heffron TP, Choo EF, Chan BK. Tellis JC, et al. Among authors: wu p. ACS Med Chem Lett. 2024 Sep 3;15(9):1606-1614. doi: 10.1021/acsmedchemlett.4c00319. eCollection 2024 Sep 12. ACS Med Chem Lett. 2024. PMID: 39291002
Differential effects of inosine monophosphate dehydrogenase (IMPDH/GuaB) inhibition in Acinetobacter baumannii and Escherichia coli.
Peng Y, Moffat JG, DuPai C, Kofoed EM, Skippington E, Modrusan Z, Gloor SL, Clark K, Xu Y, Li S, Chen L, Liu X, Wu P, Harris SF, Wang S, Crawford TD, Li CS, Liu Z, Wai J, Tan M-W. Peng Y, et al. Among authors: wu p. J Bacteriol. 2024 Oct 24;206(10):e0010224. doi: 10.1128/jb.00102-24. Epub 2024 Sep 5. J Bacteriol. 2024. PMID: 39235234 Free PMC article.
Discovery of potent dihydro-oxazinoquinolinone inhibitors of GuaB for the treatment of tuberculosis.
Zhou Y, Aliagas I, Wang S, Li CS, Liu Z, Bowman CM, Burdick DJ, Clark KR, Dening TJ, Flygare J, Ganti A, Girgis HS, Hanan EJ, Harris SF, Hu C, Kapadia SB, Koehler MFT, Lai T, Liang J, Liu X, Ma F, Mao J, Nicolai J, Sims J, Unhayaker S, Wai J, Wang X, Wu P, Xu Y, Yen CW, Zhang R, Elfert TF, Tan MW, Kofoed EM, Crawford TD. Zhou Y, et al. Among authors: wu p. Bioorg Med Chem Lett. 2024 Nov 12:130026. doi: 10.1016/j.bmcl.2024.130026. Online ahead of print. Bioorg Med Chem Lett. 2024. PMID: 39536836
Discovery of GuaB inhibitors with efficacy against Acinetobacter baumannii infection.
Kofoed EM, Aliagas I, Crawford T, Mao J, Harris SF, Xu M, Wang S, Wu P, Ma F, Clark K, Sims J, Xu Y, Peng Y, Skippington E, Yang Y, Reeder J, Ubhayakar S, Baumgardner M, Yan Z, Chen J, Park S, Zhang H, Yen C-W, Lorenzo M, Skelton N, Liang X, Chen L, Hoag B, Li CS, Liu Z, Wai J, Liu X, Liang J, Tan MW. Kofoed EM, et al. Among authors: wu p. mBio. 2024 Oct 16;15(10):e0089724. doi: 10.1128/mbio.00897-24. Epub 2024 Aug 29. mBio. 2024. PMID: 39207111 Free PMC article.
Potent and selective binders of the E3 ubiquitin ligase ZNRF3 stimulate Wnt signaling and intestinal organoid growth.
Kschonsak YT, Gao X, Miller SE, Hwang S, Marei H, Wu P, Li Y, Ruiz K, Dorighi K, Holokai L, Perampalam P, Tsai WK, Kee YS, Agard NJ, Harris SF, Hannoush RN, de Sousa E Melo F. Kschonsak YT, et al. Among authors: wu p. Cell Chem Biol. 2024 Jun 20;31(6):1176-1187.e10. doi: 10.1016/j.chembiol.2023.11.006. Epub 2023 Dec 5. Cell Chem Biol. 2024. PMID: 38056465
Multiplexed, image-based pooled screens in primary cells and tissues with PerturbView.
Kudo T, Meireles AM, Moncada R, Chen Y, Wu P, Gould J, Hu X, Kornfeld O, Jesudason R, Foo C, Höckendorf B, Corrada Bravo H, Town JP, Wei R, Rios A, Chandrasekar V, Heinlein M, Chuong AS, Cai S, Lu CS, Coelho P, Mis M, Celen C, Kljavin N, Jiang J, Richmond D, Thakore P, Benito-Gutiérrez E, Geiger-Schuller K, Hleap JS, Kayagaki N, de Sousa E Melo F, McGinnis L, Li B, Singh A, Garraway L, Rozenblatt-Rosen O, Regev A, Lubeck E. Kudo T, et al. Among authors: wu p. Nat Biotechnol. 2024 Oct 7. doi: 10.1038/s41587-024-02391-0. Online ahead of print. Nat Biotechnol. 2024. PMID: 39375449
All-perovskite tandem solar cells achieving >29% efficiency with improved (100) orientation in wide-bandgap perovskites.
Liu Z, Lin R, Wei M, Yin M, Wu P, Li M, Li L, Wang Y, Chen G, Carnevali V, Agosta L, Slama V, Lempesis N, Wang Z, Wang M, Deng Y, Luo H, Gao H, Rothlisberger U, Zakeeruddin SM, Luo X, Liu Y, Grätzel M, Tan H. Liu Z, et al. Among authors: wu p. Nat Mater. 2025 Jan 10. doi: 10.1038/s41563-024-02073-x. Online ahead of print. Nat Mater. 2025. PMID: 39794635
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