Abdelhafez EM - Search Results

1

One-pot synthesis and pharmacological evaluation of new quinoline/pyrimido-diazepines as pulmonary antifibrotic agents.

Fawzy MA, Ibrahim KH, Aly AA, Mohamed AH, Naguib Abdel Hafez SM, Abdelzaher WY, Elkaeed EB, Alsfouk AA, Abdelhafez EM. Fawzy MA, et al. Among authors: abdelhafez em. Future Med Chem. 2024;16(21):2211-2230. doi: 10.1080/17568919.2024.2394018. Epub 2024 Sep 18. Future Med Chem. 2024. PMID: 39291539 Free PMC article.

2

New quinoline-2-one/pyrazole derivatives; design, synthesis, molecular docking, anti-apoptotic evaluation, and caspase-3 inhibition assay.

Aly AA, Sayed SM, Abdelhafez EMN, Abdelhafez SMN, Abdelzaher WY, Raslan MA, Ahmed AE, Thabet K, El-Reedy AAM, Brown AB, Bräse S. Aly AA, et al. Bioorg Chem. 2020 Jan;94:103348. doi: 10.1016/j.bioorg.2019.103348. Epub 2019 Oct 9. Bioorg Chem. 2020. PMID: 31699387

3

Design, Synthesis, Molecular Docking, Antiapoptotic and Caspase-3 Inhibition of New 1,2,3-Triazole/Bis-2(1H)-Quinolinone Hybrids.

El-Sheref EM, Aly AA, Alshammari MB, Brown AB, Abdel-Hafez SMN, Abdelzaher WY, Bräse S, Abdelhafez EMN. El-Sheref EM, et al. Among authors: abdelhafez emn. Molecules. 2020 Oct 30;25(21):5057. doi: 10.3390/molecules25215057. Molecules. 2020. PMID: 33143331 Free PMC article.

4

Synthesis, Characterization, and In Vivo Study of Some Novel 3,4,5-Trimethoxybenzylidene-hydrazinecarbothioamides and Thiadiazoles as Anti-Apoptotic Caspase-3 Inhibitors.

Mostafa SM, Aly AA, Bräse S, Nieger M, Abdelhafez SMN, Abdelzaher WY, Abdelhafez EMN. Mostafa SM, et al. Molecules. 2022 Mar 31;27(7):2266. doi: 10.3390/molecules27072266. Molecules. 2022. PMID: 35408692 Free PMC article.

5

Molecular Docking and Dynamic Simulation Revealed the Potential Inhibitory Activity of Opioid Compounds Targeting the Main Protease of SARS-CoV-2.

Mahmoud SSA, Elkaeed EB, Alsfouk AA, Abdelhafez EMN. Mahmoud SSA, et al. Among authors: abdelhafez emn. Biomed Res Int. 2022 Dec 21;2022:1672031. doi: 10.1155/2022/1672031. eCollection 2022. Biomed Res Int. 2022. PMID: 36588530 Free PMC article.

6

Novel quinoline/thiazinan-4-one hybrids; design, synthesis, and molecular docking studies as potential anti-bacterial candidates against MRSA.

Mohamed AH, Mostafa SM, Aly AA, Hassan AA, Osman EM, Nayl AA, Brown AB, Abdelhafez EMN. Mohamed AH, et al. Among authors: abdelhafez emn. RSC Adv. 2023 May 12;13(21):14631-14640. doi: 10.1039/d3ra01721d. eCollection 2023 May 9. RSC Adv. 2023. PMID: 37188251 Free PMC article.

7

Discovery and Anticancer Screening of Novel Oxindole-Based Derivative Bearing Pyridyl Group as Potent and Selective Dual FLT3/CDK2 Kinase Inhibitor.

Soudi A, Bender O, Celik I, El-Hafeez AAA, Dogan R, Atalay A, Elkaeed EB, Alsfouk AA, Abdelhafez EMN, Aly OM, Sippl W, Ali TFS. Soudi A, et al. Among authors: abdelhafez emn. Pharmaceuticals (Basel). 2024 May 20;17(5):659. doi: 10.3390/ph17050659. Pharmaceuticals (Basel). 2024. PMID: 38794229 Free PMC article.

8

Metal complexes of thiosemicarbazones derived by 2-quinolones with Cu(I), Cu(II) and Ni(II); Identification by NMR, IR, ESI mass spectra and in silico approach as potential tools against SARS-CoV-2.

Aly AA, Abdallah EM, Ahmed SA, Rabee MM, Abdelhafez EMN. Aly AA, et al. Among authors: abdelhafez emn. J Mol Struct. 2022 Oct 5;1265:133480. doi: 10.1016/j.molstruc.2022.133480. Epub 2022 Jun 9. J Mol Struct. 2022. PMID: 35698532 Free PMC article.

9

New Paracyclophanylthiazoles with Anti-Leukemia Activity: Design, Synthesis, Molecular Docking, and Mechanistic Studies.

Aly AA, Bräse S, Hassan AA, Mohamed NK, Abd El-Haleem LE, Nieger M, Morsy NM, Abdelhafez EMN. Aly AA, et al. Molecules. 2020 Jul 7;25(13):3089. doi: 10.3390/molecules25133089. Molecules. 2020. PMID: 32645912 Free PMC article.

10

Potential protective effect of 3,3'-methylenebis(1-ethyl-4-hydroxyquinolin-2(1H)-one) against bleomycin-induced lung injury in male albino rat via modulation of Nrf2 pathway: biochemical, histological, and immunohistochemical study.

Hafez SMNA, Saber EA, Aziz NM, Kamel MY, Aly AA, Abdelhafez EMN, Ibrahim MFG. Hafez SMNA, et al. Among authors: abdelhafez emn. Naunyn Schmiedebergs Arch Pharmacol. 2023 Apr;396(4):771-788. doi: 10.1007/s00210-022-02324-1. Epub 2022 Dec 8. Naunyn Schmiedebergs Arch Pharmacol. 2023. PMID: 36480028 Free PMC article.

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