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Glucocorticoid excess alters metabolic rate and substrate utilisation via 11β-HSD1.
Heaselgrave SR, Heising S, Morgan SA, Carthwright DM, Sagmeister M, Hardy RS, Doig CL, Morton N, Tsintzas K, Lavery GG. Heaselgrave SR, et al. Among authors: hardy rs. J Endocrinol. 2024 Oct 28;263(2):e240205. doi: 10.1530/JOE-24-0205. Print 2024 Nov 1. J Endocrinol. 2024. PMID: 39302000 Free PMC article.
Inflammatory regulation of glucocorticoid metabolism in mesenchymal stromal cells.
Ahasan MM, Hardy R, Jones C, Kaur K, Nanus D, Juarez M, Morgan SA, Hassan-Smith Z, Bénézech C, Caamaño JH, Hewison M, Lavery G, Rabbitt EH, Clark AR, Filer A, Buckley CD, Raza K, Stewart PM, Cooper MS. Ahasan MM, et al. Arthritis Rheum. 2012 Jul;64(7):2404-13. doi: 10.1002/art.34414. Arthritis Rheum. 2012. PMID: 22294469 Free PMC article.
Glucocorticoid activation by 11β-hydroxysteroid dehydrogenase enzymes in relation to inflammation and glycaemic control in chronic kidney disease: A cross-sectional study.
Sagmeister MS, Taylor AE, Fenton A, Wall NA, Chanouzas D, Nightingale PG, Ferro CJ, Arlt W, Cockwell P, Hardy RS, Harper L. Sagmeister MS, et al. Among authors: hardy rs. Clin Endocrinol (Oxf). 2019 Jan;90(1):241-249. doi: 10.1111/cen.13889. Epub 2018 Nov 15. Clin Endocrinol (Oxf). 2019. PMID: 30358903 Free PMC article.
Therapeutic glucocorticoids prevent bone loss but drive muscle wasting when administered in chronic polyarthritis.
Fenton CG, Webster JM, Martin CS, Fareed S, Wehmeyer C, Mackie H, Jones R, Seabright AP, Lewis JW, Lai YC, Goodyear CS, Jones SW, Cooper MS, Lavery GG, Langen R, Raza K, Hardy RS. Fenton CG, et al. Among authors: hardy rs. Arthritis Res Ther. 2019 Aug 1;21(1):182. doi: 10.1186/s13075-019-1962-3. Arthritis Res Ther. 2019. PMID: 31370858 Free PMC article.
11βHSD1 Inhibition with AZD4017 Improves Lipid Profiles and Lean Muscle Mass in Idiopathic Intracranial Hypertension.
Hardy RS, Botfield H, Markey K, Mitchell JL, Alimajstorovic Z, Westgate CSJ, Sagmeister M, Fairclough RJ, Ottridge RS, Yiangou A, Storbeck KH, Taylor AE, Gilligan LC, Arlt W, Stewart PM, Tomlinson JW, Mollan SP, Lavery GG, Sinclair AJ. Hardy RS, et al. J Clin Endocrinol Metab. 2021 Jan 1;106(1):174-187. doi: 10.1210/clinem/dgaa766. J Clin Endocrinol Metab. 2021. PMID: 33098644 Free PMC article. Clinical Trial.
47 results