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Targeting Plasmodium falciparum IspD in the Methyl-d-erythritol Phosphate Pathway: Urea-Based Compounds with Nanomolar Potency on Target and Low-Micromolar Whole-Cell Activity.
Willocx D, Bizzarri L, Alhayek A, Kannan D, Bravo P, Illarionov B, Rox K, Lohse J, Fischer M, Kany AM, Hahne H, Rottmann M, Witschel M, Odom John A, Hamed MM, Diamanti E, Hirsch AKH. Willocx D, et al. Among authors: hahne h. J Med Chem. 2024 Oct 10;67(19):17070-17086. doi: 10.1021/acs.jmedchem.4c00212. Epub 2024 Sep 20. J Med Chem. 2024. PMID: 39303294 Free PMC article.
Studying Target-Engagement of Anti-Infectives by Solvent-Induced Protein Precipitation and Quantitative Mass Spectrometry.
Bizzarri L, Steinbrunn D, Quennesson T, Lacour A, Bianchino GI, Bravo P, Chaignon P, Lohse J, Mäser P, Seemann M, Calenbergh SV, Hirsch AKH, Hahne H. Bizzarri L, et al. Among authors: hahne h. ACS Infect Dis. 2024 Dec 13;10(12):4087-4102. doi: 10.1021/acsinfecdis.4c00417. Epub 2024 Nov 20. ACS Infect Dis. 2024. PMID: 39566904 Free PMC article.
High-Throughput Screening and Proteomic Characterization of Compounds Targeting Myeloid-Derived Suppressor Cells.
Krumm J, Petrova E, Lechner S, Mergner J, Boehm HH, Prestipino A, Steinbrunn D, Deline ML, Koetzner L, Schindler C, Helming L, Fromme T, Klingenspor M, Hahne H, Pieck JC, Kuster B. Krumm J, et al. Among authors: hahne h. Mol Cell Proteomics. 2023 Sep;22(9):100632. doi: 10.1016/j.mcpro.2023.100632. Epub 2023 Aug 14. Mol Cell Proteomics. 2023. PMID: 37586548 Free PMC article.
Decrypting drug actions and protein modifications by dose- and time-resolved proteomics.
Zecha J, Bayer FP, Wiechmann S, Woortman J, Berner N, Müller J, Schneider A, Kramer K, Abril-Gil M, Hopf T, Reichart L, Chen L, Hansen FM, Lechner S, Samaras P, Eckert S, Lautenbacher L, Reinecke M, Hamood F, Prokofeva P, Vornholz L, Falcomatà C, Dorsch M, Schröder A, Venhuizen A, Wilhelm S, Médard G, Stoehr G, Ruland J, Grüner BM, Saur D, Buchner M, Ruprecht B, Hahne H, The M, Wilhelm M, Kuster B. Zecha J, et al. Among authors: hahne h. Science. 2023 Apr 7;380(6640):93-101. doi: 10.1126/science.ade3925. Epub 2023 Mar 16. Science. 2023. PMID: 36926954 Free PMC article.
Degradation of CCNK/CDK12 is a druggable vulnerability of colorectal cancer.
Dieter SM, Siegl C, Codó PL, Huerta M, Ostermann-Parucha AL, Schulz E, Zowada MK, Martin S, Laaber K, Nowrouzi A, Blatter M, Kreth S, Westermann F, Benner A, Uhrig U, Putzker K, Lewis J, Haegebarth A, Mumberg D, Holton SJ, Weiske J, Toepper LM, Scheib U, Siemeister G, Ball CR, Kuster B, Stoehr G, Hahne H, Johannes S, Lange M, Herbst F, Glimm H. Dieter SM, et al. Among authors: hahne h. Cell Rep. 2021 Jul 20;36(3):109394. doi: 10.1016/j.celrep.2021.109394. Cell Rep. 2021. PMID: 34289372 Free article.
Meltome atlas-thermal proteome stability across the tree of life.
Jarzab A, Kurzawa N, Hopf T, Moerch M, Zecha J, Leijten N, Bian Y, Musiol E, Maschberger M, Stoehr G, Becher I, Daly C, Samaras P, Mergner J, Spanier B, Angelov A, Werner T, Bantscheff M, Wilhelm M, Klingenspor M, Lemeer S, Liebl W, Hahne H, Savitski MM, Kuster B. Jarzab A, et al. Among authors: hahne h. Nat Methods. 2020 May;17(5):495-503. doi: 10.1038/s41592-020-0801-4. Epub 2020 Apr 13. Nat Methods. 2020. PMID: 32284610
91 results