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Targeting Plasmodium falciparum IspD in the Methyl-d-erythritol Phosphate Pathway: Urea-Based Compounds with Nanomolar Potency on Target and Low-Micromolar Whole-Cell Activity.
Willocx D, Bizzarri L, Alhayek A, Kannan D, Bravo P, Illarionov B, Rox K, Lohse J, Fischer M, Kany AM, Hahne H, Rottmann M, Witschel M, Odom John A, Hamed MM, Diamanti E, Hirsch AKH. Willocx D, et al. Among authors: hirsch akh. J Med Chem. 2024 Oct 10;67(19):17070-17086. doi: 10.1021/acs.jmedchem.4c00212. Epub 2024 Sep 20. J Med Chem. 2024. PMID: 39303294 Free PMC article.
DXS as a target for structure-based drug design.
Gierse RM, Redeem E, Diamanti E, Wrenger C, Groves MR, Hirsch AK. Gierse RM, et al. Future Med Chem. 2017 Jul;9(11):1277-1294. doi: 10.4155/fmc-2016-0239. Epub 2017 Jun 21. Future Med Chem. 2017. PMID: 28636418 Review.
Semisynthesis and biological evaluation of amidochelocardin derivatives as broad-spectrum antibiotics.
Grandclaudon C, Birudukota NVS, Elgaher WAM, Jumde RP, Yahiaoui S, Arisetti N, Hennessen F, Hüttel S, Stadler M, Herrmann J, Miethke M, Hartmann RW, Müller R, Hirsch AKH, Brönstrup M. Grandclaudon C, et al. Among authors: hirsch akh. Eur J Med Chem. 2020 Feb 15;188:112005. doi: 10.1016/j.ejmech.2019.112005. Epub 2019 Dec 20. Eur J Med Chem. 2020. PMID: 31911294
Protein-Templated Hit Identification through an Ugi Four-Component Reaction*.
Mancini F, Unver MY, Elgaher WAM, Jumde VR, Alhayek A, Lukat P, Herrmann J, Witte MD, Köck M, Blankenfeldt W, Müller R, Hirsch AKH. Mancini F, et al. Among authors: hirsch akh. Chemistry. 2020 Nov 17;26(64):14585-14593. doi: 10.1002/chem.202002250. Epub 2020 Sep 30. Chemistry. 2020. PMID: 32428268 Free PMC article.
171 results