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A genome-wide arrayed CRISPR screen identifies PLSCR1 as an intrinsic barrier to SARS-CoV-2 entry that recent virus variants have evolved to resist.
Le Pen J, Paniccia G, Kinast V, Moncada-Velez M, Ashbrook AW, Bauer M, Hoffmann HH, Pinharanda A, Ricardo-Lax I, Stenzel AF, Rosado-Olivieri EA, Dinnon KH 3rd, Doyle WC, Freije CA, Hong SH, Lee D, Lewy T, Luna JM, Peace A, Schmidt C, Schneider WM, Winkler R, Yip EZ, Larson C, McGinn T, Menezes MR, Ramos-Espiritu L, Banerjee P, Poirier JT, Sànchez-Rivera FJ, Cobat A, Zhang Q, Casanova JL, Carroll TS, Glickman JF, Michailidis E, Razooky B, MacDonald MR, Rice CM. Le Pen J, et al. Among authors: kinast v. PLoS Biol. 2024 Sep 24;22(9):e3002767. doi: 10.1371/journal.pbio.3002767. eCollection 2024 Sep. PLoS Biol. 2024. PMID: 39316623 Free PMC article.
Targeting cellular cathepsins inhibits hepatitis E virus entry.
Klöhn M, Burkard T, Janzen J, Haase JA, Gömer A, Fu R, Ssebyatika G, Nocke MK, Brown RJP, Krey T, Dao Thi VL, Kinast V, Brüggemann Y, Todt D, Steinmann E. Klöhn M, et al. Among authors: kinast v. Hepatology. 2024 Nov 1;80(5):1239-1251. doi: 10.1097/HEP.0000000000000912. Epub 2024 May 10. Hepatology. 2024. PMID: 38728662 Free PMC article.
EGF receptor modulates HEV entry in human hepatocytes.
Schrader JA, Burkard TL, Brüggemann Y, Gömer A, Meister TL, Fu RM, Mehnert AK, Dao Thi VL, Behrendt P, Durantel D, Broering R, Vondran FWR, Todt D, Kinast V, Steinmann E. Schrader JA, et al. Among authors: kinast v. Hepatology. 2023 Jun 1;77(6):2104-2117. doi: 10.1097/HEP.0000000000000308. Epub 2023 Feb 7. Hepatology. 2023. PMID: 36745934 Free PMC article.
Janus kinase-inhibition modulates hepatitis E virus infection.
Kinast V, Andreica I, Ahrenstorf G, Gömer A, Elsner C, Schlienkamp S, Schrader JA, Klöhn M, Ulrich RG, Broering R, Vondran FWR, Todt D, Behrendt P, Dittmer U, Hamprecht A, Witte T, Baraliakos X, Steinmann E. Kinast V, et al. Antiviral Res. 2023 Sep;217:105690. doi: 10.1016/j.antiviral.2023.105690. Epub 2023 Jul 28. Antiviral Res. 2023. PMID: 37517633 Free article.
A realistic transfer method reveals low risk of SARS-CoV-2 transmission via contaminated euro coins and banknotes.
Todt D, Meister TL, Tamele B, Howes J, Paulmann D, Becker B, Brill FH, Wind M, Schijven J, Heinen N, Kinast V, Mhlekude B, Goffinet C, Krawczyk A, Steinmann J, Pfaender S, Brüggemann Y, Steinmann E. Todt D, et al. Among authors: kinast v. iScience. 2021 Aug 20;24(8):102908. doi: 10.1016/j.isci.2021.102908. Epub 2021 Jul 26. iScience. 2021. PMID: 34337354 Free PMC article.
Robust hepatitis E virus infection and transcriptional response in human hepatocytes.
Todt D, Friesland M, Moeller N, Praditya D, Kinast V, Brüggemann Y, Knegendorf L, Burkard T, Steinmann J, Burm R, Verhoye L, Wahid A, Meister TL, Engelmann M, Pfankuche VM, Puff C, Vondran FWR, Baumgärtner W, Meuleman P, Behrendt P, Steinmann E. Todt D, et al. Among authors: kinast v. Proc Natl Acad Sci U S A. 2020 Jan 21;117(3):1731-1741. doi: 10.1073/pnas.1912307117. Epub 2020 Jan 2. Proc Natl Acad Sci U S A. 2020. PMID: 31896581 Free PMC article.
25 results