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Spermidine metabolism regulates leukemia stem and progenitor cell function through KAT7 expression in patient-derived mouse models.
Rondeau V, Berman JM, Ling T, O'Brien C, Culp-Hill R, Reisz JA, Wunderlich M, Chueh Y, Jiménez-Camacho KE, Sexton C, Carter KM, Stillwell C, St-Germain J, Yendi D, Gupta A, Shi M, Bourdine A, Paralkar VR, Jahangiri S, Hope KJ, Tikhonova AN, Arruda A, Minden MD, Raught B, D'Alessandro A, Jones CL. Rondeau V, et al. Among authors: hope kj. Sci Transl Med. 2024 Sep 25;16(766):eadn1285. doi: 10.1126/scitranslmed.adn1285. Epub 2024 Sep 25. Sci Transl Med. 2024. PMID: 39321266
Very long chain fatty acid metabolism is required in acute myeloid leukemia.
Tcheng M, Roma A, Ahmed N, Smith RW, Jayanth P, Minden MD, Schimmer AD, Hess DA, Hope K, Rea KA, Akhtar TA, Bohrnsen E, D'Alessandro A, Mohsen AW, Vockley J, Spagnuolo PA. Tcheng M, et al. Blood. 2021 Jun 24;137(25):3518-3532. doi: 10.1182/blood.2020008551. Blood. 2021. PMID: 33720355 Free PMC article.
In Vivo Screening Unveils Pervasive RNA-Binding Protein Dependencies in Leukemic Stem Cells and Identifies ELAVL1 as a Therapeutic Target.
Vujovic A, de Rooij L, Chahi AK, Chen HT, Yee BA, Loganathan SK, Liu L, Chan DCH, Tajik A, Tsao E, Moreira S, Joshi P, Xu J, Wong N, Balde Z, Jahangiri S, Zandi S, Aigner S, Dick JE, Minden MD, Schramek D, Yeo GW, Hope KJ. Vujovic A, et al. Among authors: hope kj. Blood Cancer Discov. 2023 May 1;4(3):180-207. doi: 10.1158/2643-3230.BCD-22-0086. Blood Cancer Discov. 2023. PMID: 36763002 Free PMC article.
Human acute myeloid leukemia stem cells.
Hope KJ, Jin L, Dick JE. Hope KJ, et al. Arch Med Res. 2003 Nov-Dec;34(6):507-14. doi: 10.1016/j.arcmed.2003.08.007. Arch Med Res. 2003. PMID: 14734090 Review.
A role for GPx3 in activity of normal and leukemia stem cells.
Herault O, Hope KJ, Deneault E, Mayotte N, Chagraoui J, Wilhelm BT, Cellot S, Sauvageau M, Andrade-Navarro MA, Hébert J, Sauvageau G. Herault O, et al. Among authors: hope kj. J Exp Med. 2012 May 7;209(5):895-901. doi: 10.1084/jem.20102386. Epub 2012 Apr 16. J Exp Med. 2012. PMID: 22508837 Free PMC article.
42 results