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Spermidine metabolism regulates leukemia stem and progenitor cell function through KAT7 expression in patient-derived mouse models.
Rondeau V, Berman JM, Ling T, O'Brien C, Culp-Hill R, Reisz JA, Wunderlich M, Chueh Y, Jiménez-Camacho KE, Sexton C, Carter KM, Stillwell C, St-Germain J, Yendi D, Gupta A, Shi M, Bourdine A, Paralkar VR, Jahangiri S, Hope KJ, Tikhonova AN, Arruda A, Minden MD, Raught B, D'Alessandro A, Jones CL. Rondeau V, et al. Sci Transl Med. 2024 Sep 25;16(766):eadn1285. doi: 10.1126/scitranslmed.adn1285. Epub 2024 Sep 25. Sci Transl Med. 2024. PMID: 39321266
Simultaneous inhibition of Sirtuin 3 and cholesterol homeostasis targets acute myeloid leukemia stem cells by perturbing fatty acid β-oxidation and inducing lipotoxicity.
O'Brien C, Ling T, Berman JM, Culp-Hill R, Reisz JA, Rondeau V, Jahangiri S, St-Germain J, Macwan V, Astori A, Zeng A, Hong JY, Li M, Yang M, Jana S, Gamboni F, Tsao E, Liu W, Dick JE, Lin H, Melnick A, Tikhonova A, Arruda A, Minden MD, Raught B, D'Alessandro A, Jones CL. O'Brien C, et al. Among authors: rondeau v. Haematologica. 2023 Sep 1;108(9):2343-2357. doi: 10.3324/haematol.2022.281894. Haematologica. 2023. PMID: 37021547 Free PMC article.
Cysteamine dioxygenase (ADO) governs cancer cell mitochondrial redox homeostasis through proline metabolism.
Lee SCS, Pyo AHA, Mohammadi H, Zhang J, Dvorkin-Gheva A, Malbeteau L, Chung S, Khan S, Ciudad MT, Rondeau V, Cairns RA, Kislinger T, McGaha TL, Wouters BG, Reisz JA, Culp-Hill R, D'Alessandro A, Jones CL, Koritzinsky M. Lee SCS, et al. Among authors: rondeau v. Sci Adv. 2024 Oct 4;10(40):eadq0355. doi: 10.1126/sciadv.adq0355. Epub 2024 Oct 2. Sci Adv. 2024. PMID: 39356760 Free PMC article.
CXCR4 signaling determines the fate of hematopoietic multipotent progenitors by stimulating mTOR activity and mitochondrial metabolism.
Rondeau V, Kalogeraki M, Roland L, Nader ZA, Gourhand V, Bonaud A, Lemos J, Khamyath M, Moulin C, Schell B, Delord M, Bidaut G, Lecourt S, Freitas C, Anginot A, Mazure N, McDermott DH, Parietti V, Setterblad N, Dulphy N, Bachelerie F, Aurrand-Lions M, Stockholm D, Lobry C, Murphy PM, Espéli M, Mancini SJC, Balabanian K. Rondeau V, et al. Sci Signal. 2024 Oct 29;17(860):eadl5100. doi: 10.1126/scisignal.adl5100. Epub 2024 Oct 29. Sci Signal. 2024. PMID: 39471249
CXCR4 antagonism ameliorates leukocyte abnormalities in a preclinical model of WHIM syndrome.
Roland L, Nguyen CH, Zmajkovicova K, Khamyath M, Kalogeraki M, Schell B, Gourhand V, Rondeau V, Abou Nader Z, Monticelli H, Maierhofer B, Johnson R, Taveras A, Espéli M, Balabanian K. Roland L, et al. Among authors: rondeau v. Front Immunol. 2024 Nov 11;15:1468823. doi: 10.3389/fimmu.2024.1468823. eCollection 2024. Front Immunol. 2024. PMID: 39588369 Free PMC article.
104 results