Kean KM - Search Results

1

WDR5 Binding to Histone Serotonylation Is Driven by an Edge-Face Aromatic Interaction with Unexpected Electrostatic Effects.

Travis CR, Henriksen HC, Wilkinson JR, Schomburg NK, Treacy JW, Kean KM, Houk KN, Waters ML. Travis CR, et al. Among authors: kean km. J Am Chem Soc. 2024 Oct 9;146(40):27451-27459. doi: 10.1021/jacs.4c07277. Epub 2024 Sep 25. J Am Chem Soc. 2024. PMID: 39321462

2

Trimethyllysine Reader Proteins Exhibit Widespread Charge-Agnostic Binding via Different Mechanisms to Cationic and Neutral Ligands.

Travis CR, Kean KM, Albanese KI, Henriksen HC, Treacy JW, Chao EY, Houk KN, Waters ML. Travis CR, et al. Among authors: kean km. J Am Chem Soc. 2024 Feb 7;146(5):3086-3093. doi: 10.1021/jacs.3c10031. Epub 2024 Jan 24. J Am Chem Soc. 2024. PMID: 38266163

3

Contribution of Electrostatic CH₃-π Interactions to Recognition of Histone Asymmetric Dimethylarginine by the SPIN1 Triple Tudor Domain.

Travis CR, Dumais RG, Treacy JW, Kean KM, Houk KN, Waters ML. Travis CR, et al. Among authors: kean km. J Am Chem Soc. 2024 Jul 31;146(30):20678-20684. doi: 10.1021/jacs.4c03463. Epub 2024 Jul 18. J Am Chem Soc. 2024. PMID: 39023428

4

Systematic Variation of Both the Aromatic Cage and Dialkyllysine via GCE-SAR Reveal Mechanistic Insights in CBX5 Reader Protein Binding.

Kean KM, Baril SA, Lamb KN, Dishman SN, Treacy JW, Houk KN, Brustad EM, James LI, Waters ML. Kean KM, et al. J Med Chem. 2022 Feb 10;65(3):2646-2655. doi: 10.1021/acs.jmedchem.1c02049. Epub 2022 Jan 11. J Med Chem. 2022. PMID: 35014255 Free PMC article.

5

Evolution and Distribution of C₇-Cyclitol Synthases in Prokaryotes and Eukaryotes.

Osborn AR, Kean KM, Alseud KM, Almabruk KH, Asamizu S, Lee JA, Karplus PA, Mahmud T. Osborn AR, et al. Among authors: kean km. ACS Chem Biol. 2017 Apr 21;12(4):979-988. doi: 10.1021/acschembio.7b00066. Epub 2017 Feb 17. ACS Chem Biol. 2017. PMID: 28182402 Free PMC article.

6

Mismatched covalent and noncovalent templating leads to large coiled coil-templated macrocycles.

Stingley KJ, Carpenter BA, Kean KM, Waters ML. Stingley KJ, et al. Among authors: kean km. Chem Sci. 2023 Apr 3;14(18):4935-4944. doi: 10.1039/d3sc00231d. eCollection 2023 May 10. Chem Sci. 2023. PMID: 37181761 Free PMC article.

7

Modifying the resolving cysteine affects the structure and hydrogen peroxide reactivity of peroxiredoxin 2.

Peskin AV, Meotti FC, Kean KM, Göbl C, Peixoto AS, Pace PE, Horne CR, Heath SG, Crowther JM, Dobson RCJ, Karplus PA, Winterbourn CC. Peskin AV, et al. Among authors: kean km. J Biol Chem. 2021 Jan-Jun;296:100494. doi: 10.1016/j.jbc.2021.100494. Epub 2021 Mar 2. J Biol Chem. 2021. PMID: 33667550 Free PMC article.

8

Immobilization of Proteins with Controlled Load and Orientation.

Bednar RM, Golbek TW, Kean KM, Brown WJ, Jana S, Baio JE, Karplus PA, Mehl RA. Bednar RM, et al. Among authors: kean km. ACS Appl Mater Interfaces. 2019 Oct 9;11(40):36391-36398. doi: 10.1021/acsami.9b12746. Epub 2019 Sep 26. ACS Appl Mater Interfaces. 2019. PMID: 31525993

9

Structure and role for active site lid of lactate monooxygenase from Mycobacterium smegmatis.

Kean KM, Karplus PA. Kean KM, et al. Protein Sci. 2019 Jan;28(1):135-149. doi: 10.1002/pro.3506. Epub 2018 Oct 3. Protein Sci. 2019. PMID: 30207005 Free PMC article.

10

Structural insights into a thermostable variant of human carbonic anhydrase II.

Kean KM, Porter JJ, Mehl RA, Karplus PA. Kean KM, et al. Protein Sci. 2018 Feb;27(2):573-577. doi: 10.1002/pro.3347. Epub 2017 Nov 27. Protein Sci. 2018. PMID: 29139171 Free PMC article.

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