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Combining RAS(ON) G12C-selective inhibitor with SHP2 inhibition sensitises lung tumours to immune checkpoint blockade.
Anastasiou P, Moore C, Rana S, Tomaschko M, Pillsbury CE, de Castro A, Boumelha J, Mugarza E, de Carné Trécesson S, Mikolajczak A, Blaj C, Goldstone R, Smith JAM, Quintana E, Molina-Arcas M, Downward J. Anastasiou P, et al. Among authors: de carne trecesson s, de castro a. Nat Commun. 2024 Sep 25;15(1):8146. doi: 10.1038/s41467-024-52324-3. Nat Commun. 2024. PMID: 39322643 Free PMC article.
CRISPR-Cas9 Screening Identifies KRAS-Induced COX2 as a Driver of Immunotherapy Resistance in Lung Cancer.
Boumelha J, de Castro A, Bah N, Cha H, de Carné Trécesson S, Rana S, Tomaschko M, Anastasiou P, Mugarza E, Moore C, Goldstone R, East P, Litchfield K, Lee SH, Molina-Arcas M, Downward J. Boumelha J, et al. Among authors: de carne trecesson s, de castro a. Cancer Res. 2024 Jul 15;84(14):2231-2246. doi: 10.1158/0008-5472.CAN-23-2627. Cancer Res. 2024. PMID: 38635884 Free PMC article.
Spatial multiplex analysis of lung cancer reveals that regulatory T cells attenuate KRAS-G12C inhibitor-induced immune responses.
Cole M, Anastasiou P, Lee C, Yu X, de Castro A, Roelink J, Moore C, Mugarza E, Jones M, Valand K, Rana S, Colliver E, Angelova M, Enfield KSS, Magness A, Mullokandov A, Kelly G, de Gruijl TD, Molina-Arcas M, Swanton C, Downward J, van Maldegem F. Cole M, et al. Among authors: de castro a. Sci Adv. 2024 Nov;10(44):eadl6464. doi: 10.1126/sciadv.adl6464. Epub 2024 Nov 1. Sci Adv. 2024. PMID: 39485838 Free PMC article.
Color evaluation of a one-shade used for restoration of non-carious cervical lesions: an equivalence randomized clinical trial.
Favoreto MW, de Oliveira de Miranda A, Matos TP, de Castro ADS, de Abreu Cardoso M, Beatriz J, Collantes-Acuña J, Reis A, Loguercio AD. Favoreto MW, et al. Among authors: de castro ads. BMC Oral Health. 2024 Dec 4;24(1):1464. doi: 10.1186/s12903-024-05108-6. BMC Oral Health. 2024. PMID: 39633376 Free PMC article. Clinical Trial.
Visual simulation of intraocular lenses: from on-bench performance to computational and experimental validations.
Papadogiannis P, Gambra E, Łabuz G, Yan W, Martín-Becerra D, Sisó-Fuertes I, de Castro A, Barcala X, Auffarth GU, Dorronsoro C, Sawides L. Papadogiannis P, et al. Among authors: de castro a. Biomed Opt Express. 2024 Oct 25;15(11):6521-6530. doi: 10.1364/BOE.538878. eCollection 2024 Nov 1. Biomed Opt Express. 2024. PMID: 39553883 Free PMC article.
The Functional Transcriptomic Landscape Informs Therapeutic Strategies in Multiple Myeloma.
Sudalagunta PR, Canevarolo RR, Meads MB, Silva M, Zhao X, Cubitt CL, Sansil SS, DeAvila G, Alugubelli RR, Bishop RT, Tungesvik A, Zhang Q, Hampton O, Teer JK, Welsh EA, Yoder SJ, Shah BD, Hazlehurst L, Gatenby RA, Van Domelen DR, Chai Y, Wang F, DeCastro A, Bloomer AM, Siegel EM, Lynch CC, Sullivan DM, Alsina M, Nishihori T, Brayer J, Cleveland JL, Dalton W, Walker CJ, Landesman Y, Baz R, Silva AS, Shain KH. Sudalagunta PR, et al. Cancer Res. 2024 Oct 30. doi: 10.1158/0008-5472.CAN-24-0886. Online ahead of print. Cancer Res. 2024. PMID: 39476082
805 results