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Protein kinase N1 deficiency results in upregulation of cerebral energy metabolism and is highly protective in in vivo and in vitro stroke models.
Zur Nedden S, Safari MS, Weber D, Kuenkel L, Garmsiri C, Lang L, Orset C, Freret T, Haelewyn B, Hotze M, Kwiatkowski M, Sarg B, Faserl K, Savic D, Skvortsova II, Krogsdam A, Carollo S, Trajanoski Z, Oberacher H, Zlotek D, Ostermaier F, Cameron A, Baier G, Baier-Bitterlich G. Zur Nedden S, et al. Among authors: freret t. Metabolism. 2024 Dec;161:156039. doi: 10.1016/j.metabol.2024.156039. Epub 2024 Sep 26. Metabolism. 2024. PMID: 39332493 Free article.
Usefulness of Time-Point Serum Cortisol and ACTH Measurements for the Adjustment of Glucocorticoid Replacement in Adrenal Insufficiency.
Rousseau E, Joubert M, Trzepla G, Parienti JJ, Freret T, Vanthygem MC, Desailloud R, Lefebvre H, Coquerel A, Reznik Y; PHAD Study Group. Rousseau E, et al. Among authors: freret t. PLoS One. 2015 Aug 28;10(8):e0135975. doi: 10.1371/journal.pone.0135975. eCollection 2015. PLoS One. 2015. PMID: 26317782 Free PMC article. Clinical Trial.
Therapeutic Potential of 5-HT6 Receptor Agonists.
Karila D, Freret T, Bouet V, Boulouard M, Dallemagne P, Rochais C. Karila D, et al. Among authors: freret t. J Med Chem. 2015 Oct 22;58(20):7901-12. doi: 10.1021/acs.jmedchem.5b00179. Epub 2015 Jul 2. J Med Chem. 2015. PMID: 26099069 Review.
Novel multitarget-directed ligands (MTDLs) with acetylcholinesterase (AChE) inhibitory and serotonergic subtype 4 receptor (5-HT4R) agonist activities as potential agents against Alzheimer's disease: the design of donecopride.
Rochais C, Lecoutey C, Gaven F, Giannoni P, Hamidouche K, Hedou D, Dubost E, Genest D, Yahiaoui S, Freret T, Bouet V, Dauphin F, Sopkova de Oliveira Santos J, Ballandonne C, Corvaisier S, Malzert-Fréon A, Legay R, Boulouard M, Claeysen S, Dallemagne P. Rochais C, et al. Among authors: freret t. J Med Chem. 2015 Apr 9;58(7):3172-87. doi: 10.1021/acs.jmedchem.5b00115. Epub 2015 Mar 31. J Med Chem. 2015. PMID: 25793650 Free article.
Design, synthesis, and pharmacological evaluation of multitarget-directed ligands with both serotonergic subtype 4 receptor (5-HT4R) partial agonist and 5-HT6R antagonist activities, as potential treatment of Alzheimer's disease.
Yahiaoui S, Hamidouche K, Ballandonne C, Davis A, de Oliveira Santos JS, Freret T, Boulouard M, Rochais C, Dallemagne P. Yahiaoui S, et al. Among authors: freret t. Eur J Med Chem. 2016 Oct 4;121:283-293. doi: 10.1016/j.ejmech.2016.05.048. Epub 2016 May 26. Eur J Med Chem. 2016. PMID: 27266998
Dopaminergic neuromodulation of prefrontal cortex activity requires the NMDA receptor coagonist d-serine.
Dallérac G, Li X, Lecouflet P, Morisot N, Sacchi S, Asselot R, Pham TH, Potier B, Watson DJG, Schmidt S, Levasseur G, Fossat P, Besedin A, Rivet JM, Coyle JT, Collo G, Pollegioni L, Kehr J, Galante M, Fone KC, Gardier AM, Freret T, Contarino A, Millan MJ, Mothet JP. Dallérac G, et al. Among authors: freret t. Proc Natl Acad Sci U S A. 2021 Jun 8;118(23):e2023750118. doi: 10.1073/pnas.2023750118. Proc Natl Acad Sci U S A. 2021. PMID: 34083436 Free PMC article.
117 results