Yang Y - Search Results

1

Multiplexed Target Profiling with Integrated Chemical Genomics and Chemical Proteomics.

Yang Y, Tse YS, Zhang Q, Wong KY, Yang C, Yang Y, Li S, Lau KW, Charles TC, Lam TC, Zhao Q. Yang Y, et al. Among authors: yang c. J Med Chem. 2024 Oct 10;67(19):17542-17550. doi: 10.1021/acs.jmedchem.4c01463. Epub 2024 Sep 28. J Med Chem. 2024. PMID: 39340453

2

High-throughput hydrogen bond strength calculation and its applications in optimizing drug ADME properties.

Shen J, Yang Y, Broughton H, Watson IA, Desai PV. Shen J, et al. Among authors: yang y. Future Med Chem. 2019 Mar;11(6):511-524. doi: 10.4155/fmc-2018-0470. Epub 2019 Mar 20. Future Med Chem. 2019. PMID: 30892942

3

Non-peptidic immunoproteasome β5i-selective inhibitor as potential treatment for idiopathic pulmonary fibrosis: Virtual screening, hit evolution and lead identification.

Li Y, Nan G, Hou X, Yan Y, Yang Y, Yang Y, Li K, Xiao Z. Li Y, et al. Among authors: yang y. Eur J Med Chem. 2023 Dec 5;261:115856. doi: 10.1016/j.ejmech.2023.115856. Epub 2023 Oct 6. Eur J Med Chem. 2023. PMID: 37826934

4

Targeting the pyruvate dehydrogenase complex/pyruvate dehydrogenase kinase (PDC/PDK) axis to discover potent PDK inhibitors through structure-based virtual screening and pharmacological evaluation.

Gan L, Yang Y, Liang Z, Zhang M, He Y, Zhang SL. Gan L, et al. Among authors: yang y. Eur J Med Chem. 2024 Jan 15;264:116008. doi: 10.1016/j.ejmech.2023.116008. Epub 2023 Dec 3. Eur J Med Chem. 2024. PMID: 38056298

5

Identification of N-phenyl-N-(quinolin-4-yl) amino carboxylic acids as URAT1 inhibitors with hypouricemic effects.

Hou X, Shao M, Zhang L, Yang Y, Xiao Z. Hou X, et al. Among authors: yang y. Bioorg Med Chem Lett. 2025 Mar 1;117:130053. doi: 10.1016/j.bmcl.2024.130053. Epub 2024 Dec 4. Bioorg Med Chem Lett. 2025. PMID: 39638156

6

Discovery of new and highly effective quadruple FFA1 and PPARα/γ/δ agonists as potential anti-fatty liver agents.

Zhou Z, Ren Q, Jiao S, Cai Z, Geng X, Deng L, Wang B, Hu L, Zhang L, Yang Y, Li Z. Zhou Z, et al. Among authors: yang y. Eur J Med Chem. 2022 Feb 5;229:114061. doi: 10.1016/j.ejmech.2021.114061. Epub 2021 Dec 21. Eur J Med Chem. 2022. PMID: 34954593

7

Design, synthesis, and biological evaluation of novel highly potent FXR agonists bearing piperidine scaffold.

Wang W, Cai Z, Liang Z, Liao Z, Liu Y, Geng X, Yang Y, Chen Y, Huang Z, Yang Y, Li Z. Wang W, et al. Among authors: yang y. Eur J Med Chem. 2025 Jan 15;282:117082. doi: 10.1016/j.ejmech.2024.117082. Epub 2024 Nov 19. Eur J Med Chem. 2025. PMID: 39580912

8

Highly oxygenated ent-abietane diterpenoid lactones from Euphorbia peplus and their anti-inflammatory activity.

Yan Y, Peng MY, Yang Y, Zhang ZB, Zhang LL, Tang L, Qin XJ, Cheng YY, Di YT, Hao XJ. Yan Y, et al. Among authors: yang y. Bioorg Chem. 2025 Jan;154:107989. doi: 10.1016/j.bioorg.2024.107989. Epub 2024 Nov 22. Bioorg Chem. 2025. PMID: 39591686

9

Elucidating the multiple roles of hydration for accurate protein-ligand binding prediction via deep learning.

Mahmoud AH, Masters MR, Yang Y, Lill MA. Mahmoud AH, et al. Among authors: yang y. Commun Chem. 2020 Feb 11;3(1):19. doi: 10.1038/s42004-020-0261-x. Commun Chem. 2020. PMID: 36703428 Free PMC article.

10

Safety and efficacy of tirofiban in the endovascular treatment of intracranial aneurysms: a systematic evaluation and meta-analysis.

Xiao Z, Wang B, Yang Y, Huang M, Liu J, Duan Y, Liu A. Xiao Z, et al. Among authors: yang y. Neurosurg Rev. 2025 Jan 28;48(1):91. doi: 10.1007/s10143-025-03208-7. Neurosurg Rev. 2025. PMID: 39871064 Review.

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