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A Kinetic Scout Approach Accelerates Targeted Protein Degrader Development.
Fan AT, Gadbois GE, Huang HT, Jiang J, Sigua LH, Smith ER, Wu S, Dunne-Dombrink K, Goyal P, Tao AJ, Sellers W, Fischer ES, Donovan KA, Ferguson FM. Fan AT, et al. Among authors: fischer es. bioRxiv [Preprint]. 2024 Sep 21:2024.09.17.612508. doi: 10.1101/2024.09.17.612508. bioRxiv. 2024. Update in: Angew Chem Int Ed Engl. 2024 Nov 27:e202417272. doi: 10.1002/anie.202417272 PMID: 39345570 Free PMC article. Updated. Preprint.
Development and Characterization of a Wee1 Kinase Degrader.
Li Z, Pinch BJ, Olson CM, Donovan KA, Nowak RP, Mills CE, Scott DA, Doctor ZM, Eleuteri NA, Chung M, Sorger PK, Fischer ES, Gray NS. Li Z, et al. Among authors: fischer es. Cell Chem Biol. 2020 Jan 16;27(1):57-65.e9. doi: 10.1016/j.chembiol.2019.10.013. Epub 2019 Nov 14. Cell Chem Biol. 2020. PMID: 31735695 Free PMC article.
Development of CDK2 and CDK5 Dual Degrader TMX-2172.
Teng M, Jiang J, He Z, Kwiatkowski NP, Donovan KA, Mills CE, Victor C, Hatcher JM, Fischer ES, Sorger PK, Zhang T, Gray NS. Teng M, et al. Among authors: fischer es. Angew Chem Int Ed Engl. 2020 Aug 10;59(33):13865-13870. doi: 10.1002/anie.202004087. Epub 2020 Jun 3. Angew Chem Int Ed Engl. 2020. PMID: 32415712 Free PMC article.
Proteomics-Based Identification of DUB Substrates Using Selective Inhibitors.
Bushman JW, Donovan KA, Schauer NJ, Liu X, Hu W, Varca AC, Buhrlage SJ, Fischer ES. Bushman JW, et al. Among authors: fischer es. Cell Chem Biol. 2021 Jan 21;28(1):78-87.e3. doi: 10.1016/j.chembiol.2020.09.005. Epub 2020 Oct 1. Cell Chem Biol. 2021. PMID: 33007217 Free PMC article.
Mapping the Degradable Kinome Provides a Resource for Expedited Degrader Development.
Donovan KA, Ferguson FM, Bushman JW, Eleuteri NA, Bhunia D, Ryu S, Tan L, Shi K, Yue H, Liu X, Dobrovolsky D, Jiang B, Wang J, Hao M, You I, Teng M, Liang Y, Hatcher J, Li Z, Manz TD, Groendyke B, Hu W, Nam Y, Sengupta S, Cho H, Shin I, Agius MP, Ghobrial IM, Ma MW, Che J, Buhrlage SJ, Sim T, Gray NS, Fischer ES. Donovan KA, et al. Among authors: fischer es. Cell. 2020 Dec 10;183(6):1714-1731.e10. doi: 10.1016/j.cell.2020.10.038. Epub 2020 Dec 3. Cell. 2020. PMID: 33275901 Free PMC article.
Discovery of a Potent Degrader for Fibroblast Growth Factor Receptor 1/2.
Du G, Jiang J, Wu Q, Henning NJ, Donovan KA, Yue H, Che J, Lu W, Fischer ES, Bardeesy N, Zhang T, Gray NS. Du G, et al. Among authors: fischer es. Angew Chem Int Ed Engl. 2021 Jul 12;60(29):15905-15911. doi: 10.1002/anie.202101328. Epub 2021 Jun 14. Angew Chem Int Ed Engl. 2021. PMID: 33915015 Free PMC article.
133 results