Sleebs BE - Search Results

1

Author Correction: Aryl amino acetamides prevent Plasmodium falciparum ring development via targeting the lipid-transfer protein PfSTART1.

Dans MG, Boulet C, Watson GM, Nguyen W, Dziekan JM, Evelyn C, Reaksudsan K, Mehra S, Razook Z, Geoghegan ND, Mlodzianoski MJ, Goodman CD, Ling DB, Jonsdottir TK, Tong J, Famodimu MT, Kristan M, Pollard H, Stewart LB, Brandner-Garrod L, Sutherland CJ, Delves MJ, McFadden GI, Barry AE, Crabb BS, de Koning-Ward TF, Rogers KL, Cowman AF, Tham WH, Sleebs BE, Gilson PR. Dans MG, et al. Among authors: sleebs be. Nat Commun. 2024 Sep 30;15(1):8459. doi: 10.1038/s41467-024-52849-7. Nat Commun. 2024. PMID: 39349462 Free PMC article. No abstract available.

2

Role of plasmepsin V in export of diverse protein families from the Plasmodium falciparum exportome.

Boddey JA, Carvalho TG, Hodder AN, Sargeant TJ, Sleebs BE, Marapana D, Lopaticki S, Nebl T, Cowman AF. Boddey JA, et al. Among authors: sleebs be. Traffic. 2013 May;14(5):532-50. doi: 10.1111/tra.12053. Epub 2013 Feb 27. Traffic. 2013. PMID: 23387285 Free article.

3

Transition state mimetics of the Plasmodium export element are potent inhibitors of Plasmepsin V from P. falciparum and P. vivax.

Sleebs BE, Gazdik M, O'Neill MT, Rajasekaran P, Lopaticki S, Lackovic K, Lowes K, Smith BJ, Cowman AF, Boddey JA. Sleebs BE, et al. J Med Chem. 2014 Sep 25;57(18):7644-62. doi: 10.1021/jm500797g. Epub 2014 Sep 11. J Med Chem. 2014. PMID: 25167370

4

Macrolides rapidly inhibit red blood cell invasion by the human malaria parasite, Plasmodium falciparum.

Wilson DW, Goodman CD, Sleebs BE, Weiss GE, de Jong NW, Angrisano F, Langer C, Baum J, Crabb BS, Gilson PR, McFadden GI, Beeson JG. Wilson DW, et al. Among authors: sleebs be. BMC Biol. 2015 Jul 18;13:52. doi: 10.1186/s12915-015-0162-0. BMC Biol. 2015. PMID: 26187647 Free PMC article.

5

Structural basis for plasmepsin V inhibition that blocks export of malaria proteins to human erythrocytes.

Hodder AN, Sleebs BE, Czabotar PE, Gazdik M, Xu Y, O'Neill MT, Lopaticki S, Nebl T, Triglia T, Smith BJ, Lowes K, Boddey JA, Cowman AF. Hodder AN, et al. Among authors: sleebs be. Nat Struct Mol Biol. 2015 Aug;22(8):590-6. doi: 10.1038/nsmb.3061. Epub 2015 Jul 27. Nat Struct Mol Biol. 2015. PMID: 26214367

6

Exploration of the P3 region of PEXEL peptidomimetics leads to a potent inhibitor of the Plasmodium protease, plasmepsin V.

Gazdik M, Jarman KE, O'Neill MT, Hodder AN, Lowes KN, Jousset Sabroux H, Cowman AF, Boddey JA, Sleebs BE. Gazdik M, et al. Among authors: sleebs be. Bioorg Med Chem. 2016 May 1;24(9):1993-2010. doi: 10.1016/j.bmc.2016.03.027. Epub 2016 Mar 16. Bioorg Med Chem. 2016. PMID: 27021426

7

Analysis of Ca²⁺ mediated signaling regulating Toxoplasma infectivity reveals complex relationships between key molecules.

Stewart RJ, Whitehead L, Nijagal B, Sleebs BE, Lessene G, McConville MJ, Rogers KL, Tonkin CJ. Stewart RJ, et al. Among authors: sleebs be. Cell Microbiol. 2017 Apr;19(4). doi: 10.1111/cmi.12685. Epub 2017 Jan 9. Cell Microbiol. 2017. PMID: 27781359

8

Optimization of 2-Anilino 4-Amino Substituted Quinazolines into Potent Antimalarial Agents with Oral in Vivo Activity.

Gilson PR, Tan C, Jarman KE, Lowes KN, Curtis JM, Nguyen W, Di Rago AE, Bullen HE, Prinz B, Duffy S, Baell JB, Hutton CA, Jousset Subroux H, Crabb BS, Avery VM, Cowman AF, Sleebs BE. Gilson PR, et al. Among authors: sleebs be. J Med Chem. 2017 Feb 9;60(3):1171-1188. doi: 10.1021/acs.jmedchem.6b01673. Epub 2017 Jan 26. J Med Chem. 2017. PMID: 28080063

9

Mefloquine targets the Plasmodium falciparum 80S ribosome to inhibit protein synthesis.

Wong W, Bai XC, Sleebs BE, Triglia T, Brown A, Thompson JK, Jackson KE, Hanssen E, Marapana DS, Fernandez IS, Ralph SA, Cowman AF, Scheres SHW, Baum J. Wong W, et al. Among authors: sleebs be. Nat Microbiol. 2017 Mar 13;2:17031. doi: 10.1038/nmicrobiol.2017.31. Nat Microbiol. 2017. PMID: 28288098 Free PMC article.

10

Enhanced antimalarial activity of plasmepsin V inhibitors by modification of the P₂ position of PEXEL peptidomimetics.

Nguyen W, Hodder AN, de Lezongard RB, Czabotar PE, Jarman KE, O'Neill MT, Thompson JK, Jousset Sabroux H, Cowman AF, Boddey JA, Sleebs BE. Nguyen W, et al. Among authors: sleebs be. Eur J Med Chem. 2018 Jun 25;154:182-198. doi: 10.1016/j.ejmech.2018.05.022. Epub 2018 May 18. Eur J Med Chem. 2018. PMID: 29800827

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