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Intranasal parainfluenza virus-vectored vaccine expressing SARS-CoV-2 spike protein of Delta or Omicron B.1.1.529 induces mucosal and systemic immunity and protects hamsters against homologous and heterologous challenge.
Park HS, Matsuoka Y, Santos C, Luongo C, Liu X, Yang L, Kaiser JA, Duncan EF, Johnson RF, Teng IT, Kwong PD, Buchholz UJ, Le Nouën C. Park HS, et al. Among authors: le nouen c. bioRxiv [Preprint]. 2024 Sep 13:2024.09.12.612598. doi: 10.1101/2024.09.12.612598. bioRxiv. 2024. PMID: 39372768 Free PMC article. Preprint.
Live-attenuated pediatric parainfluenza vaccine expressing 6P-stabilized SARS-CoV-2 spike protein is protective against SARS-CoV-2 variants in hamsters.
Liu X, Park HS, Matsuoka Y, Santos C, Yang L, Luongo C, Moore IN, Johnson RF, Garza NL, Zhang P, Lusso P, Best SM, Buchholz UJ, Le Nouën C. Liu X, et al. Among authors: le nouen c. bioRxiv [Preprint]. 2022 Dec 13:2022.12.12.520032. doi: 10.1101/2022.12.12.520032. bioRxiv. 2022. Update in: PLoS Pathog. 2023 Jun 23;19(6):e1011057. doi: 10.1371/journal.ppat.1011057 PMID: 36561185 Free PMC article. Updated. Preprint.
A single intranasal dose of a live-attenuated parainfluenza virus-vectored SARS-CoV-2 vaccine is protective in hamsters.
Liu X, Luongo C, Matsuoka Y, Park HS, Santos C, Yang L, Moore IN, Afroz S, Johnson RF, Lafont BAP, Martens C, Best SM, Munster VJ, Hollý J, Yewdell JW, Le Nouën C, Munir S, Buchholz UJ. Liu X, et al. Among authors: le nouen c. Proc Natl Acad Sci U S A. 2021 Dec 14;118(50):e2109744118. doi: 10.1073/pnas.2109744118. Proc Natl Acad Sci U S A. 2021. PMID: 34876520 Free PMC article.
Intranasal immunization with avian paramyxovirus type 3 expressing SARS-CoV-2 spike protein protects hamsters against SARS-CoV-2.
Park HS, Matsuoka Y, Luongo C, Yang L, Santos C, Liu X, Ahlers LRH, Moore IN, Afroz S, Johnson RF, Lafont BAP, Dorward DW, Fischer ER, Martens C, Samal SK, Munir S, Buchholz UJ, Le Nouën C. Park HS, et al. Among authors: le nouen c. NPJ Vaccines. 2022 Jun 28;7(1):72. doi: 10.1038/s41541-022-00493-x. NPJ Vaccines. 2022. PMID: 35764659 Free PMC article.
Intranasal pediatric parainfluenza virus-vectored SARS-CoV-2 vaccine is protective in monkeys.
Le Nouën C, Nelson CE, Liu X, Park HS, Matsuoka Y, Luongo C, Santos C, Yang L, Herbert R, Castens A, Moore IN, Wilder-Kofie T, Moore R, Walker A, Zhang P, Lusso P, Johnson RF, Garza NL, Via LE, Munir S, Barber DL, Buchholz UJ. Le Nouën C, et al. Cell. 2022 Dec 8;185(25):4811-4825.e17. doi: 10.1016/j.cell.2022.11.006. Epub 2022 Nov 10. Cell. 2022. PMID: 36423629 Free PMC article.
Live-attenuated pediatric parainfluenza vaccine expressing 6P-stabilized SARS-CoV-2 spike protein is protective against SARS-CoV-2 variants in hamsters.
Liu X, Park HS, Matsuoka Y, Santos C, Yang L, Luongo C, Moore IN, Johnson RF, Garza NL, Zhang P, Lusso P, Best SM, Buchholz UJ, Le Nouën C. Liu X, et al. Among authors: le nouen c. PLoS Pathog. 2023 Jun 23;19(6):e1011057. doi: 10.1371/journal.ppat.1011057. eCollection 2023 Jun. PLoS Pathog. 2023. PMID: 37352333 Free PMC article.
Intranasal murine pneumonia virus-vectored SARS-CoV-2 vaccine induces mucosal and serum antibodies in macaques.
Kaiser JA, Liu X, Luongo C, Matsuoka Y, Santos C, Yang L, Herbert R, Castens A, Dorward DW, Johnson RF, Park HS, Afroz S, Munir S, Le Nouën C, Buchholz UJ. Kaiser JA, et al. Among authors: le nouen c. iScience. 2023 Nov 22;26(12):108490. doi: 10.1016/j.isci.2023.108490. eCollection 2023 Dec 15. iScience. 2023. PMID: 38144450 Free PMC article.
Mucosal prime-boost immunization with live murine pneumonia virus-vectored SARS-CoV-2 vaccine is protective in macaques.
Kaiser JA, Nelson CE, Liu X, Park HS, Matsuoka Y, Luongo C, Santos C, Ahlers LRH, Herbert R, Moore IN, Wilder-Kofie T, Moore R, Walker A, Yang L, Munir S, Teng IT, Kwong PD, Dowdell K, Nguyen H, Kim J, Cohen JI, Johnson RF, Garza NL, Via LE, Barber DL, Buchholz UJ, Le Nouën C. Kaiser JA, et al. Among authors: le nouen c. Nat Commun. 2024 Apr 26;15(1):3553. doi: 10.1038/s41467-024-47784-6. Nat Commun. 2024. PMID: 38670948 Free PMC article.
IL-10 suppresses T cell expansion while promoting tissue-resident memory cell formation during SARS-CoV-2 infection in rhesus macaques.
Nelson CE, Foreman TW, Kauffman KD, Sakai S, Gould ST, Fleegle JD, Gomez F; NIAID/DIR Tuberculosis Imaging Program; Le Nouën C, Liu X, Burdette TL, Garza NL, Lafont BAP, Brooks K, Arlehamn CSL, Weiskopf D, Sette A, Hickman HD, Buchholz UJ, Johnson RF, Brenchley JM, Via LE, Barber DL. Nelson CE, et al. Among authors: le nouen c. bioRxiv [Preprint]. 2022 Sep 15:2022.09.13.507852. doi: 10.1101/2022.09.13.507852. bioRxiv. 2022. Update in: PLoS Pathog. 2024 Jul 1;20(7):e1012339. doi: 10.1371/journal.ppat.1012339 PMID: 36172119 Free PMC article. Updated. Preprint.
Mucosal prime-boost immunization with live murine pneumonia virus-vectored SARS-CoV-2 vaccine is protective in macaques.
Buchholz U, Kaiser J, Nelson C, Liu X, Park HS, Matsuoka Y, Luongo C, Santos C, Ahlers L, Herbert R, Moore I, Wilder-Kofie T, Moore R, Walker A, Lijuan Y, Munir S, Teng IT, Kwong P, Dowdell K, Nguyen H, Kim J, Cohen J, Johnson RF, Garza N, Via L, Barber D, LE Nouen C. Buchholz U, et al. Among authors: le nouen c. Res Sq [Preprint]. 2023 Sep 13:rs.3.rs-3278289. doi: 10.21203/rs.3.rs-3278289/v1. Res Sq. 2023. Update in: Nat Commun. 2024 Apr 26;15(1):3553. doi: 10.1038/s41467-024-47784-6 PMID: 37790295 Free PMC article. Updated. Preprint.
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