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Page 1
Principles of paralog-specific targeted protein degradation engaging the C-degron E3 KLHDC2.
Scott DC, Dharuman S, Griffith E, Chai SC, Ronnebaum J, King MT, Tangallapally R, Lee C, Gee CT, Yang L, Li Y, Loudon VC, Lee HW, Ochoada J, Miller DJ, Jayasinghe T, Paulo JA, Elledge SJ, Harper JW, Chen T, Lee RE, Schulman BA. Scott DC, et al. Among authors: dharuman s. Nat Commun. 2024 Oct 12;15(1):8829. doi: 10.1038/s41467-024-52966-3. Nat Commun. 2024. PMID: 39396041 Free PMC article.
Correction: Synthesis and antibacterial action of 3',6'-disubstituted spectinomycins.
Dharuman S, Phelps GA, Dunn CM, Wilt LA, Murphy PA, Lee RB, Snoke HE, Selchow P, Haldimann K, Böttger EC, Hobbie SN, Sander P, Lee RE. Dharuman S, et al. J Antibiot (Tokyo). 2024 Oct 11. doi: 10.1038/s41429-024-00777-5. Online ahead of print. J Antibiot (Tokyo). 2024. PMID: 39394258 No abstract available.
Synthesis and antibacterial action of 3',6'-disubstituted spectinomycins.
Dharuman S, Phelps GA, Dunn CM, Wilt LA, Murphy PA, Lee RB, Snoke HE, Selchow P, Haldimann K, Böttger EC, Hobbie SN, Sander P, Lee RE. Dharuman S, et al. J Antibiot (Tokyo). 2024 Sep;77(9):577-588. doi: 10.1038/s41429-024-00750-2. Epub 2024 Jun 18. J Antibiot (Tokyo). 2024. PMID: 38890386 Free PMC article.
Development of 2nd generation aminomethyl spectinomycins that overcome native efflux in Mycobacterium abscessus.
Phelps GA, Cheramie MN, Fernando DM, Selchow P, Meyer CJ, Waidyarachchi SL, Dharuman S, Liu J, Meuli M, Molin MD, Killam BY, Murphy PA, Reeve SM, Wilt LA, Anderson SM, Yang L, Lee RB, Temrikar ZH, Lukka PB, Meibohm B, Polikanov YS, Hobbie SN, Böttger EC, Sander P, Lee RE. Phelps GA, et al. Among authors: dharuman s. Proc Natl Acad Sci U S A. 2024 Jan 9;121(2):e2314101120. doi: 10.1073/pnas.2314101120. Epub 2024 Jan 2. Proc Natl Acad Sci U S A. 2024. PMID: 38165935 Free PMC article.
Combating Multidrug-Resistant Bacteria by Integrating a Novel Target Site Penetration and Receptor Binding Assay Platform Into Translational Modeling.
Lang Y, Shah NR, Tao X, Reeve SM, Zhou J, Moya B, Sayed ARM, Dharuman S, Oyer JL, Copik AJ, Fleischer BA, Shin E, Werkman C, Basso KB, Deveson Lucas D, Sutaria DS, Mégroz M, Kim TH, Loudon-Hossler V, Wright A, Jimenez-Nieves RH, Wallace MJ, Cadet KC, Jiao Y, Boyce JD, LoVullo ED, Schweizer HP, Bonomo RA, Bharatham N, Tsuji BT, Landersdorfer CB, Norris MH, Soo Shin B, Louie A, Balasubramanian V, Lee RE, Drusano GL, Bulitta JB. Lang Y, et al. Among authors: dharuman s. Clin Pharmacol Ther. 2021 Apr;109(4):1000-1020. doi: 10.1002/cpt.2205. Epub 2021 Mar 24. Clin Pharmacol Ther. 2021. PMID: 33576025 Free PMC article.
Discovery and Characterization of the Antimetabolite Action of Thioacetamide-Linked 1,2,3-Triazoles as Disruptors of Cysteine Biosynthesis in Gram-Negative Bacteria.
Wallace MJ, Dharuman S, Fernando DM, Reeve SM, Gee CT, Yao J, Griffith EC, Phelps GA, Wright WC, Elmore JM, Lee RB, Chen T, Lee RE. Wallace MJ, et al. Among authors: dharuman s. ACS Infect Dis. 2020 Mar 13;6(3):467-478. doi: 10.1021/acsinfecdis.9b00406. Epub 2020 Jan 13. ACS Infect Dis. 2020. PMID: 31887254 Free PMC article.
21 results